Huber, Robert J. - Trent University - Department of Biology

研究领域

Dictyostelium discoideum Neuronal ceroid lipofuscinosis (Batten disease) Extracellular matrix Signal transduction Cell motility and adhesion Calcium and calmodulin Cyclin-dependent kinases

近期论文

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Huber, R.J., Myre, M.A. and Cotman, S.L. Aberrant adhesion impacts early development in a Dictyostelium model for juvenile neuronal ceroid lipofuscinosis. Cell Adhesion & Migration, in press. doi: 10.1080/19336918.2016.1236179 Huber, R.J. and O’Day, D.H. (2017). Extracellular matrix dynamics and functions in the social amoeba Dictyostelium: A critical review. Biochimica et Biophysica Acta (BBA) - General Subjects 186(1):2971-2980. doi: 10.1016/j.bbagen.2016.09 Huber, R.J. (2016). Using Dictyostelium to study the functions of proteins linked to neuronal ceroid lipofuscinosis. Journal of Biomedical Science 23(1):83. doi: 10.1186/s12929-016-0301-0 Huber, R.J. and O’Day, D.H. (2015). Proteomic profiling of the extracellular matrix (slime sheath) of Dictyostelium discoideum. Proteomics 15(19):3315-3319. doi: 10.1002/pmic.201500143 Huber, R.J., Myre, M.A. and Cotman, S.L. (2014). Loss of Cln3 function in the social amoeba Dictyostelium discoideum causes pleiotropic effects that are rescued by human CLN3. PLoS One 9(10):e110544 plus supplementary data. doi: 10.1371/journal.pone.0110544 Kovacs-Bogdan, E., Sancak, Y., Kamer, K.J., Plovanich, M., Jambhekar, A., Huber, R.J., Myre, M.A., Blower, M.D. and Mootha, V.K. (2014). Reconstitution of the mitochondrial calcium uniporter in yeast. Proceedings of the National Academy of Sciences of the United States of America 111(24):8985-8990 plus supplementary data. doi: 10.1073/pnas.1400514111 Huber, R.J. (2014). The cyclin-dependent kinase family in the social amoebozoan Dictyostelium discoideum. Cellular and Molecular Life Sciences 71(4):629-639. doi: 10.1007/s00018-013-1449-3 O’Day, D.H. and Huber, R.J. (2013). Matricellular signal transduction involving calmodulin in the social amoebozoan Dictyostelium. Genes 4(1):33-45. doi: 10.3390/genes4010033 Huber, R.J., Catalano, A. and O’Day, D.H. (2013). Cyclin-dependent kinase 5 is a calmodulin-binding protein that associates with puromycin-sensitive aminopeptidase in the nucleus of Dictyostelium. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1833(1):11-20. doi: 10.1016/j.bbamcr.2012.10.005 Huber, R.J. and O’Day, D.H. (2012). A matricellular protein and EGF-like repeat signalling in the social amoebozoan Dictyostelium discoideum. Cellular and Molecular Life Sciences 69(23):3989–3997. doi: 10.1007/s00018-012-1068-4 O’Day, D.H., Huber, R.J. and Suarez, A. (2012). Extracellular calmodulin regulates growth and cAMP-mediated chemotaxis in Dictyostelium discoideum. Biochemical and Biophysical Research Communications 425(4):750-754. doi: 10.1016/j.bbrc.2012.07.147 Huber, R.J. and O’Day, D.H. (2012). EGF-like peptide-enhanced cell movement in Dictyostelium is mediated by protein kinases and the activity of several cytoskeletal proteins. Cellular Signalling 24(9):1770–1780 plus supplementary data. doi: 10.1016/j.cellsig.2012.05.004 Huber, R.J., Suarez, A. and O’Day, D.H. (2012). CyrA, a matricellular protein that modulates cell motility in Dictyostelium discoideum. Matrix Biology 31(4):271-280. doi: 10.1016/j.matbio.2012.02.003 Huber, R.J. and O’Day, D.H. (2012). The cyclin-dependent kinase inhibitor roscovitine inhibits kinase activity, cell proliferation, multicellular development, and Cdk5 nuclear translocation in Dictyostelium discoideum. Journal of Cellular Biochemistry 113(3):868-876 plus supplementary data. doi: 10.1002/jcb.23417 Nikolaeva, I., Huber, R.J. and O’Day, D.H. (2012). EGF-like peptide of Dictyostelium discoideum is not a chemoattractant but it does restore folate-mediated chemotaxis in the presence of signal transduction inhibitors. Peptides 34(1):145-149. doi: 10.1016/j.peptides.2011.12.014 Huber, R.J. and O’Day, D.H. (2011). Nucleocytoplasmic transfer of cyclin dependent kinase 5 and its binding to puromycin-sensitive aminopeptidase in Dictyostelium discoideum. Histochemistry and Cell Biology 136(2):177-189. doi: 10.1007/s00418-011-0839-6 O'Day, D.H., Huber, R.J. and Suarez, A. (2012). Calmodulin Signaling Inside-Out: Intracellular and Extracellular Calmodulin and its Interaction with a Matricellular, Cysteine-Rich Calmodulin-Binding Protein. Chapter 4, In: Calcium Signaling, M. Yamaguchi (Editor), Nova Science Publishers Inc., Hauppauge, NY, pp. 105-118 (invited). ISBN: 978-1-61324-313-8 Suarez, A., Huber, R.J., Myre, M.A. and O’Day, D.H. (2011). An extracellular matrix, calmodulin-binding protein from Dictyostelium with EGF-like repeats that enhance cell motility. Cellular Signalling 23(7):1197-1206. doi: 10.1016/j.cellsig.2011.03.008 Huber, R. and O’Day, D.H. (2011). EGF-like peptide-enhanced cell motility in Dictyostelium functions independently of the cAMP-mediated pathway and requires active Ca2+/calmodulin signaling. Cellular Signalling 23(4):731-738. doi: 10.1016/j.cellsig.2010.12.007 Huber, R. and O’Day, D.H. (2009). An EGF-like peptide sequence from Dictyostelium enhances cell motility and chemotaxis. Biochemical and Biophysical Research Communications 379(2):470–475 plus supplementary data. doi: 10.1016/j.bbrc.2008.12.081