个人简介

Ph.D., Chemistry, University of Washington, 1979 B.S., Chemistry, State University of New York at Buffalo, 1975

研究领域

Analytical/Bioanalytical/Environmental/Biotechnology

McGown’s research projects fall into several broad categories, including biomaterials, nanotechnology, affinity techniques, bioseparations, genomic DNA and prebiotic chemistry. Techniques employed in her research include fluorescence, ultraviolet-visible absorption and circular dichroism spectroscopies, capillary electrophoresis and electrochromatography, MALDI-mass spectrometry, and imaging. Current research interests in the McGown group include design and applications of guanosine gels, solubilization and manipulation of carbon nanotubes, affinity MALDI-mass spectrometry, aptamers, the role of genomic G-quadruplex DNA in human diseases such as diabetes and cancer, prebiotic RNA synthesis and astrobiology.

近期论文

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Zhang, X., McGown, L. B., Sequence-based Separation of Single-Stranded by uisng Nucleotides in Capillary Electrophoresis, Electrophoresis, in press. Zhang, T., Zhang, H., Wang, Y., McGown, L.B., Capture and Identification of Proteins that Bind to a GGA-Rich Sequence from the ERBB2 Gene Promoter Region, Anal. Bioanal. Chem., 404, 1867-1876 (2012). Dong, Y., McGown, L.B., Chiral Selectivity of Guanosine Media in Capillary Electrophoresis, Electrophoresis, 32, 1735-41 (2011). Dong, Y., McGown, L.B., Incorporation of Guanosine Gels into Sieving Matrices for Length- and Sequence-Based Separation of DNA in Capillary Electrophoresis, Electrophoresis, 32, 1209-16 (2011). Cassidy, L.M., Dong, Y., Joshi, P.C., Aldersley, M.F., Ferris, J.P., McGown, L.B., Signal Enhancement of Abiotically-Synthesized RNA Oligonucleotides and other Biopolymers using Unmodified Fused Silica in MALDI-MS, J. Am. Soc. Mass. Spectrom., 22, 1100-1104 (2011). Xiao, J.F., McGown, L.B., DNA-Modified ITO Surfaces for Affinity MALDI-MS, Anal. Methods, 2, 1160–1165 (2010). Xiao, J.F., McGown, L.B., Determination of ILPR G-quadruplex Binding Sites in Insulin and IGF-2 using MALDI Mass Spectrometry, J. Am. Soc. Mass. Spectrom., 20, 1974-82 (2009). Wang, Y., Zhang, H., Ligon, L.A., McGown, L.B., Association of Insulin-Like Growth Factor 2 with the Insulin-Linked Polymorphic Region in Cultured Fetal Thymus Cells”, Biochem., 48, 8189-94 (2009). Xiao, J.F., Carter, J., Frederick, K.A., McGown, L.B., A Genome-Inspired DNA Ligand for Affinity Capture of Insulin and Insulin-like Growth Factor-2, J. Sep. Sci., 32, 1654-1664 (2009). Yu, Y., Nakamura, D.T., DeBoyace, K., Neisius, A.W., McGown, L.B., Tunable Thermoassociation of Binary Guanosine Gels, J. Phys. Chem. B, 112, 1130-1134 (2008). Case, W.S., Glinert, K.D., LaBarge, S., McGown, L.B., Guanosine Gel for Sequence-Dependent Separation of Polymorphic ssDNA, Electrophoresis, 28, 3008-3016 (2007). Cole, J.R., Dick Jr., L.W., Morgan, E.J., McGown, L.B., Affinity Capture and Detection of Immunoglobulin E in Human Serum using an Aptamer-Modified Surface in Matrix Assisted Laser Desorption/Ionization Mass Spectrometry, Anal. Chem., 79, 273-279 (2007). Connor, A.C., Frederick, K.A., Morgan, E.J., McGown, L.B., Insulin Capture by an Insulin-linked Polymorphic Region G-Quadruplex DNA Oligonucleotide, J. Amer. Chem. Soc., 128, 4986-91 (2006). Connor, A.C., McGown, L.B., Aptamer Stationary Phases for Protein Capture in Affinity Capillary Chromatography, J. Chromatogr. A, 1111, 115-119 (2006). Snyder, T.K., McGown, L.B., Multiplex Single Strand Conformation Polymorphism Analysis by Capillary Electrophoresis with On-the-Fly Fluorescence Lifetime Detection, Applied Spectrosc., 59, 335-339 (2005). Dick Jr., L.W., McGown, L.B., Aptamer-Enhanced Laser Desorption/Ionization for Affinity Mass Spectrometry, Anal. Chem., 76, 3037-3041 (2004).