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研究领域

Inflammatory Bowel Diseases (Crohn's disease, ulcerative colitis, and indeterminate colitis) - etiology - role of the microbiome - probiotics - patient care - treatments Celiac disease - treatments for patents Fecal microbiota transplantation - treatment for recurrent Clostridium difficile infections

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The probiotic VSL#3 has anti-inflammatory effects and could reduce endoscopic recurrence after surgery for Crohn's disease Author(s): Fedorak RN, Feagan BG, Hotte N, Leddin D, Dieleman LA, Petrunia DM, Enns R, Bitton A, Chiba N, Paré P, Rostom A, Marshall J, Depew W, Bernstein CN, Panaccione R, Aumais G, Steinhart AH, Cockeram A, Bailey RJ, Gionchetti P, Wong C, Madsen K Publication Date: 2015 Journal: Clinical Gastroenterology and Hepatology Volume: 13 Issue: 5 Page Numbers: 928-935 Description: BACKGROUND & AIMS: Probiotic formulations of single speci... read more Publication Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=25460016 Vedolizumab as induction and maintenance therapy for Crohn's disease Author(s): Sandborn WJ, Feagan BG, Rutgeerts P, Hanauer S, Colombel JF, Sands BE, Lukas M, Fedorak RN, Lee S, Bressler B, Fox I, Rosario M, Sankoh S, Xu J, Stephens K, Milch C, Parikh A; GEMINI 2 Study Group Publication Date: 2013-08-22 Journal: New England Journal of Medicine Volume: 369 Issue: 8 Page Numbers: 711-721 Description: BACKGROUND: The efficacy of vedolizumab, an α4β7 integrin ant... read more Publication Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=23964933 Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo-controlled study. Author(s): Kelly CP, Green PH, Murray JA, Dimarino A, Colatrella A, Leffler DA, Alexander T, Arsenescu R, Leon F, Jiang JG, Arterburn LA, Paterson BM, Fedorak RN; Larazotide Acetate Celiac Disease Study Group. Publication Date: 2013 Journal: Alimentary Pharmacology and Therapeutics Volume: 37 Issue: 2 Page Numbers: 252-262 Description: BACKGROUND: Coeliac disease, an autoimmune disorder triggered... read more Publication Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=23163616 Patients with IBD are exposed to high levels of ionizing radiation through CT scan diagnostic imaging: a five-year study Author(s): Kroeker KI, Lam S, Birchall I, Fedorak RN. Publication Date: 2011 Journal: Journal of Clinical Gastroenterology Volume: 45 Issue: 1 Page Numbers: 34-39 Description: GOALS: The objective of this study was to assess the total ef... read more Publication Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=20679907 Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial Author(s): Hanauer SB, Sandborn WJ, Rutgeerts P, Fedorak RN, Lukas M, MacIntosh D, Panaccione R, Wolf D, Pollack P Publication Date: 2006 Journal: Gastroenterology Volume: 130 Issue: 2 Page Numbers: 323-333 Description: BACKGROUND & AIMS: Tumor necrosis factor blockade has bee... read more Publication Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=16472588

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