Zaugg, Michael - University of Alberta - Department of Pharmacology

个人简介

eMBA-Health Care Managament/Hospital Finance-Alberta School of Business, 2011 FRCPC (Ottawa, Canada), 2008 Basic Science Fellowship-Cell Biology and Cardiovascular Physiology, State University of New York (New York, USA), 1997 MD-University of Zurich (Zurich, Switzerland), 1989

研究领域

Perioperative organ damage frequently occurs in multi morbid patients and is a major concern. Our translational research projects in humans (volunteers), patients, and in animal models investigate the mechanisms underlying novel therapies of organ protection, specifically heart protection by the aid of proteomics, transcriptomics, genetics, and more recently metabolomics. Our projects also investigate mechanisms of organ protection by stem cell therapies.

近期论文

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Aguirre JA, Lucchinetti E, Clanachan AS, Plane F and Zaugg M. (2016) Unraveling Interactions Between Anesthetics and the Endothelium: Update and Novel Insights. Anesth Analg 122(2):330-48. PMID: 26797549. Rigassi L, Barchiesi Bozzolo F, Lucchinetti E, Zaugg M, Fingerle J, Rosselli M, Imthurn B, Jackson EK and Dubey RK. (2015) 2-Methoxyestradiol blocks the RhoA/ROCK1 pathway in human aortic smooth muscle cells. Am J Physiol Endocrinol Metab 309(12):E995-E1007. PMID: 26487003. Zaugg M and Lucchinetti E. (2015) Remote Ischemic Preconditioning in Cardiac Surgery--Ineffective and Risky? N Engl J Med 373(15):1470-2. PMID: 26436209. Lou PH, Lucchinetti E, Zhang L, Affolter A, Gandhi M, Zhakupova A, Hersberger M, Hornemann T, Clanachan AS and Zaugg M. (2015) Propofol (Diprivan®) and Intralipid® Exacerbate Insulin Resistance in Type-2 Diabetic Hearts by Impairing GLUT4 Trafficking. Anesth Analg 120(2):329-40. PMID: 25437926. Zaugg M and Lucchinetti E. (2014) Sevoflurane--compared with propofol-based anesthesia reduces the need for inotropic support in patients undergoing abdominal aortic aneurysm repair: evidence of cardioprotection by volatile anesthetics in noncardiac surgery. Anesthesiology 120(5):1289-90. PMID: 24755800. Lou PH, Lucchinetti E, Zhang L, Affolter A, Schaub MC, Gandhi M, Hersberger M, Warren BE, Lemieux H, Sobhi HF, Clanachan AS, Zaugg M. (2014) The mechanism of Intralipid®-mediated cardioprotection complex IV inhibition by the active metabolite, palmitoylcarnitine, generates reactive oxygen species and activates reperfusion injury salvage kinases. PLoS One 9(1):e87205. PMID: 24498043. Lou PH, Zhang L, Lucchinetti E, Heck M, Affolter A, Gandhi M, Kienesberger PC, Hersberger M, Clanachan AS, Zaugg M. (2013) Infarct-remodelled hearts with limited oxidative capacity boost fatty acid oxidation after conditioning against ischaemia/reperfusion injury. Cardiovasc Res 97(2):251-61. PMID: 23097573. Lucchinetti E, Awad AE, Rahman M, Feng J, Lou PH, Zhang L, Ionescu L, Lemieux H, Thébaud B, Zaugg M. (2012) Antiproliferative effects of local anesthetics on mesenchymal stem cells: potential implications for tumor spreading and wound healing. Anesthesiology 116(4):841-56. PMID: 22343474. Zaugg M, Wang L, Zhang L, Lou PH, Lucchinetti E, Clanachan AS. (2012) Choice of Anesthetic Combination Determines Ca2+ Leak after Ischemia-Reperfusion Injury in the Working Rat Heart: Favorable versus Adverse Combinations. Anesthesiology 116(3):648-57. PMID: 22293718. Lucchinetti E, Bestmann L, Feng J, Freidank H, Clanachan AS, Finegan BA, Zaugg M. (2012) Remote ischemic preconditioning applied during isoflurane inhalation provides no benefit to the myocardium of patients undergoing on-pump coronary artery bypass graft surgery: lack of synergy or evidence of antagonism in cardioprotection? Anesthesiology 116(2):296-310. PMID: 22222469. Feng J, Zhu M, Schaub MC, Gehrig P, Roschitzki B, Lucchinetti E, Zaugg M. (2008) Phosphoproteome analysis of isoflurane-protected heart mitochondria: phosphorylation of adenine nucleotide translocator-1 on Tyr194 regulates mitochondrial function. Cardiovasc Res 80(1):20-9. PMID: 18558627. Zaugg M, Bestmann L, Wacker J, Lucchinetti E, Boltres A, Schulz C, Hersberger M, Kaelin G, Furrer L, Hofer C, Blumenthal S, Mueller A, Zollinger A, Spahn DR, Borgeat A. (2007) Adrenergic receptor genotype but not perioperative bisoprolol therapy may determine cardiovascular outcome in at-risk patients undergoing surgery with spinal block: the Swiss Beta Blocker in Spinal Anesthesia (BBSA) study: a double-blinded, placebo-controlled, multicenter trial with 1-year follow-up. Anesthesiology 107(1):33-44. PMID: 17585213. Lucchinetti E, Hofer C, Bestmann L, Hersberger M, Feng J, Zhu M, Furrer L, Schaub MC, Tavakoli R, Genoni M, Zollinger A, Zaugg M. (2007) Gene regulatory control of myocardial energy metabolism predicts postoperative cardiac function in patients undergoing off-pump coronary artery bypass graft surgery: inhalational versus intravenous anesthetics. Anesthesiology 106(3):444-57. PMID: 17325502. Lucchinetti E, Ambrosio S, Aguirre J, Herrmann P, Härter L, Keel M, Meier T, Zaugg M. (2007) Sevoflurane inhalation at sedative concentrations provides endothelial protection against ischemia-reperfusion injury in humans. Anesthesiology 106(2):262-8. PMID: 17264719. Julier K, da Silva R, Garcia C, Bestmann L, Frascarolo P, Zollinger A, Chassot PG, Schmid ER, Turina MI, von Segesser LK, Pasch T, Spahn DR, Zaugg M. (2003) Preconditioning by sevoflurane decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery: a double-blinded, placebo-controlled, multicenter study. Anesthesiology 98(6):1315-27. PMID: 12766638. Zaugg M, Lucchinetti E, Spahn DR, Pasch T, Schaub MC. (2002) Volatile anesthetics mimic cardiac preconditioning by priming the activation of mitochondrial K(ATP) channels via multiple signaling pathways. Anesthesiology 97(1):4-14. PMID: 12131097.