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Pillai, B., M.M.Cherney, K. Hiraga, K Takada, K.Oda and Michael N.G.James. Crystal Structure of Scytalidoglutamic Peptidase with its First Potent Inhibitor Provides Insight into Substrate Specificity and Catalysis. J. Mol. Biol. 365:343-361(2007). Maynes, J.T., M.M. Cherney, M.A. Qasim, M. Laskowski Jr. & M.N. James. Structure of the subtilisin Carlsberg-OMTKY3 complex reveals two different ovomucoid conformations. Acta Crystallogr D Biol Crystallogr 61:580-588 (2005). Biswal, B.K., M.M. Cherney, M. Wang, L. Chan, C.G. Yannopoulos, D. Bilimoria, O. Nicolas, J. Bedard & M.N. James. Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J. Biol. Chem. 280:18202-18210 (2005). Maynes, J.T., K.R. Perreault, M.M. Cherney, H.A. Luu, M.N.G. James & C.F.B. Holmes. Crystal structure and mutagenesis of a protein phosphatase-1:calcineurin hybrid elucidate the role of the Beta12-Beta13 loop in inhibitor binding. J. Biol. Chem. 279:43198-206 (2004). Fujinaga, M., M.M. Cherney, H. Oyama, K. Oda & M.N.G. James. The molecular structure and catalytic mechanism of a novel carboxyl peptidase from Scytalidium lignicolum. Proc. Natl. Acad. Sci. USA 101:3364 3369 (2004). Wang, M., K.K.S. Ng, M.M. Cherney, L. Chan, C.G. Yannopoulos, J. Bedard, N. Morin, N. Nguyen-Ba, M.H. Alaoui-Ismaili, R.C. Bethell & M.N.G. James. Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. J. Biol. Chem. 278:9489-9495 (2003). Mark, B.L., D.J. Mahuran, M.M. Cherney, D. Zhao, S. Knapp & M.N.G. James. Crystal structure of human Beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease. J. Mol. Biol. 327:1093-1109 (2003). Barrette-Ng, I.H., K.K. Ng, M.M. Cherney, G. Pearce, C.A. Ryan & M.N. James. Structural basis of inhibition revealed by a 1:2 complex of the two-headed tomato inhibitor-II and subtilisin Carlsberg. J. Biol. Chem. 278:24062-24071 (2003). Barrette-Ng, I.H., K.K. Ng, M.M. Cherney, G. Pearce, U. Ghani, C.A. Ryan & M.N. James. Unbound form of tomato inhibitor-II reveals interdomain flexibility and conformational variability in the reactive site loops. J. Biol. Chem. 278:31391-31400 (2003). Ng, K.K., M.M. Cherney, A.L. Vazquez, A. Machin, J.M. Alonso, F. Parra & M.N. James. Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase. J. Biol. Chem. 277:1381-1387 (2002). Holmes, C.F.B., J.T. Maynes, K.R. Perreault, J.F. Dawson & M.N.G. James. Molecular enzymology underlying regulation of protein phosphatase-1 by natural toxins. Curr. Med. Chem. 9:1981-1989 (2002). Maynes, J.T., K.S. Bateman, M.M. Cherney, A.K. Das, H.A. Luu, C.F. Holmes, M.N. James. Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1. J. Biol. Chem. 276:44078 44082 (2001). Ng, K.K.S., J.F. Petersen, M.M. Cherney, C. Garen, J.J. Zalatoris, C. Rao-Naik, B.M. Dunn, M.R. Martzen, R.J. Peanasky & M.N.G. James. Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3. Nature Structural Biology 7:653-657 (2000). Bergmann, E.M. & M.N.G. James. The 3C Proteinases of Picornaviruses and other Positive-Sense, Single-Stranded RNA Viruses. In Proteases as Targets for Therapy (K. von der Helm, B.D. Korant & J.C. Cheronis, Eds.). Handbook of Experimental Pharmacology, Chap. 7, Vol. 140, pp. 117-143. Springer-Verlag (2000). Bergmann, E.M., M.M. Cherney, J. McKendrick, S. Frormann, C. Luo, B.A. Malcolm, J.C. Vederas & M.N.G. James. Crystal structure of an inhibitor complex of the 3C proteinase from hepatitis A virus (HAV) and implications for the polyprotein processing in HAV. Virology 265:153-163 (1999). (PDB Accession Code: 1QA7). Bergmann, E.M. & M.N.G. James. Proteolytic enzymes of the viruses of the family picornaviridae. In Proteases of Infectious Agents (B. Dunn, Ed.), pp. 139-163, Academic Press. (1999). Petersen, J.F.W., M.M. Cherney, H.-D. Liebig, T. Skern, E. Kuechler & M.N.G. James. The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host cell protein synthesis. EMBO J. 18:5463-5475 (1999).