Godbout, Roseline - University of Alberta - Department of Biochemistry

研究领域

My research group has three main areas of interest: (i) regulation of gene expression during retinal development (see Project Details – Project 1), (ii) characterization of a DEAD box protein called DDX1 in the human tumour of the retina called retinoblastoma (Project 2), and (iii) induction of differentiation in brain tumours (Project 3) Projects 1 and 2: Retinoblastoma, a childhood tumour of the eye, occurs when both copies of the retinoblastoma (RB) gene are mutated in retinal precursor cells. In spite of extensive investigations of the RB gene, no one truly understands how retinal precursor cells become tumorigenic. We are using different approaches spanning the fields of molecular biology, cellular biology and developmental biology, to study the spectrum of changes in retinal cells compared to retinoblastoma tumour cells. Project 3: Malignant gliomas are deadly brain tumours that are extremely aggressive and hard to treat. We believe that malignant glioma tumours are derived from a glial cell that is normally highly invasive during brain development. We propose that a better understanding of the genes expressed in normal glial cells will shed light on how to control the aggressive properties of brain tumours.

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Liu, R.-Z., Mita, R., Beaulieu, M., Gao, Z. and Godbout, R. Fatty acid binding proteins in brain development and diseases. Int. J. Dev. Biol. 54: 1229-1239 (2010). Li. X., Glubrecht, D.D. and Godbout, R. The AP-2 transcription factor induces apoptosis in retinoblastoma cells. Genes Chromosomes Cancer 49: 819-830 (2010). Germain, D.R., Graham, K., Glubrecht, D.D., Hugh, J.C., Mackey, J.R. and Godbout, R. DEAD Box 1: A Novel and Independent Prognostic Marker for Early Recurrence in Breast Cancer. Breast Cancer Res. Treat. 127: 53-63 (2011). Gao, Z., Monckton, E.A., Glubrecht, D.D. and Godbout, R. Early Isoform of Disabled-1 Functions Independently of Reelin-mediated Tyrosine Phosphorylation in Chick Retina. Mol. Cell. Biol. 30: 4339-4353 (2010). Mita, R., Beaulieu, M.J., Field, C. and Godbout, R. Brain Fatty Acid-binding Protein and ω-3/ω-6 Fatty Acids: Mechanistic Insight into Malignant Glioma Cell Migration. J. Biol. Chem. 285: 37005-37015 (2010). Gao, Z. and Godbout, R. Serine Phosphorylation Regulates Disabled-1 Early Isoform Turnover Independently of Reelin. Cell. Signal. 23: 555-565 (2011). Liu, R.-Z., Graham, K., Glubrecht, D.D., Germain, D.R., Mackey, J.R. and Godbout, R. Association of FABP5 expression with poor survival in triple-negative breast cancer: implication for retinoic acid therapy. Am. J. Pathol. 178: 997-1008 (2011). Germain, D.R., Graham, K., Glubrecht, D.D., Hugh, J.C., Mackey, J.R. and Godbout, R. DEAD Box 1: A Novel and Independent Prognostic Marker for Early Recurrence in Breast Cancer. Breast Cancer Res. Treat. 127: 53-63 (2011). Katyal, S., Glubrecht, D.D., Li, L. Gao, Z. and Godbout, R. Disabled-1 alternative splicing in human fetal retina and neural tumors. PLoS ONE 6: e28579 (pgs. 1-12) (2011). Liu, R.-Z., Graham, K., Glubrecht, D.D., Lai, R., Mackey, J.R. and Godbout, R. A Fatty Acid-binding Protein 7/RXRb Pathway Enhances Survival and Proliferation in Triple-negative Breast Cancer. J. Pathol. 228: 310-321 (2012). Liu, R.Z., Monckton, E.A. and Godbout, R. Regulation of the FABP7 gene by PAX6 in malignant glioma cells. Biochem. Biophys. Res. Comm. 422: 482–487 (2012). Gao, Z., Poon, H.Y., Li, L., Li, X., Palmesino, E., Glubrecht, D., Colwill, K., Dutta, I., Kania, A., Pawson, T. and Godbout, R. Splice-mediated motif switching regulates Disabled-1 phosphorylation and SH2 domain interactions. Mol. Cell. Biol. 32: 2794-2808 (2012). Gao, Z. and Godbout, R. Reelin-Disabled-1 signaling in neuronal migration: Splicing takes the stage. Cell. Mol. Life Sci. 70: 2319-2329 (2013). Brun, M., Glubrecht, D.D., Baksh, S. and Godbout, R. Calcineurin regulates Nuclear Factor I dephosphorylation and activity in malignant glioma cell lines. J. Biol. Chem. 288: 24104–24115 (2013). Elsherbiny, M., Emara, M. and Godbout, R. Interaction of brain fatty acid-binding protein with the polyunsaturated fatty acid environment as a potential determinant of poor prognosis in malignant glioma. Prog. Lipid Res. 52: 562-570 (2013). Li, X., Monckton, E.A. and Godbout, R. Ectopic Expression of Transcription Factor AP-2delta in Developing Retina: Effect on PSA-NCAM and Axon Routing. J. Neurochem. 129: 72–84 (2014). Li, X., Persad, A.R.L., Monckton, E.A. and Godbout, R. Transcription Factor AP-2delta Regulates the Expression of Polysialyltransferase ST8SIA2 in Chick Retina. FEBS Lett. 588: 770–775 (2014). Hildebrandt, M.R., Germain, D.R., Monckton, E.A., Brun, M. and Godbout, R. Ddx1 knockout results in transgenerational wild-type lethality in mice. Sci. Rep. 5: 9829, pgs. 1-8 (2015). Liu, R.-Z., Garcia, E., Glubrecht, D.D., Poon, H.Y., Mackey, J.R. and Godbout, R. CRABP1 is Associated with a Poor Prognosis in Breast Cancer: Adding to the Complexity of Breast Cancer Cell Response to Retinoic Acid. Mol. Cancer 14:129, pgs. 1-16 (2015). Germain, D., Li, L., Hildebrandt, M.R., Simmonds, A.J., Hughes, S.C. and Godbout, R. Loss of Drosophila melanogaster DEAD box protein Ddx1 leads to reduced size and aberrant gametogenesis. Dev. Biol. 407: 232-245 (2015). Elsherbiny, M.E., Goruk, S., Monckton, E.A., Richard, C., Brun, M., Emara, M., Field, C.J. and Godbout, R. Long-term effect of docosahexaenoic acid feeding on lipid composition and brain fatty acid-binding protein expression in rats. Nutrients 7: 8802-8817 (2015). Liu, R.-Z., Li, S., Garcia, E., Glubrecht, D.D, Poon, H.-Y., Easaw, J.C. and Godbout, R. Association between cytoplasmic CRABP2, altered retinoic acid signaling and poor prognosis in glioblastoma. GLIA 64: 963-976 (2016). Li, X., Gaillard, F., Monckton, E.A., Glubrecht, D.D., Persad, A. R. L., Moser, M., Sauve, Y and Godbout, R. Loss of AP-2delta Reduces Retinal Ganglion Cell Numbers and Axonal Projections to the Superior Colliculus. Mol. Brain 9: 62 (pgs. 1-21) (2016).