个人简介

Education Ph.D. Brandeis University (1979.9-1984.5) M.S. Seoul National University (1976.3-1978.2) B.S. Seoul National University (1972.3-1976.2) Career 1984.6. ~ 1986.6. Post-doc, Department of Chemistry, M.I.T. 1986.7. ~ 1988.8. Assistant Professor, Department of Chemistry, KAIST 1988.8. ~ 1995.2. Associate Professor, Department of Chemistry, KAIST 1995.3 ~ Present Professor, Department of Chemistry, KAIST Academes and Society 1987 ~ Present Korean Chemical Society 1987 ~ Present Korean Society of Biochemistry and Molecular Biology 1992 ~ Present Korean Magnetic Resonance Society 1992 ~ Present Korean Biophysics Society

研究领域

Structural Biochemistry (NMR spectroscopy)

The human genome is under constant attack from endogenous metabolic byproducts and environmental factors that can alter the chemical structure and corrupt its encoded message. The accumulation of somatic damage is now considered a main cause of the cancers as well as aging process. To cope with these DNA damage, organisms evolved an intricate network of DNA damage repair pathways, each focusing on a different class of DNA lesion. Our research focuses upon understanding the mechanism of damaged DNA recognition and propagating cellular events of damaged DNA repair system at the level of atomic resolution. Research topics Damaged DNA / Repair / Mutagenesis cyclic-di-GMP binding receptor Influenza A virus panhandle RNA

近期论文

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Minjee Jeong, Ae-Ree Lee, Hee-Eun Kim, Yong-Geun Choi, Byong-Seok Choi, Joon-Hwa Lee, NMR study of the Z-DNA binding mode and B–Z transition activity of the Zα domain of human ADAR1 when perturbed by mutation on the α3 helix and β-hairpin, Archives of Biochemistry and Biophysics [In press], 2014 Chin-Ju Park, Junsang Ko, Kyoung-Seok Ryu, Byong-Seok Choi, Solution structure of the RecQ C-terminal domain of human Bloom syndrome protein, J Biomol NMR Vol.58, pp.141-147, 2014 Mi-Kyung Lee, Angel Bottini, Meehyein Kim, Michael F. Bardaro Jr., Ziming Zhang, Maurizio Pellecchia, Byong-Seok Choi and Gabriele Varani, A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication, Chem. Commum. Vol.50, pp.368-370, 2014 Soyoung Lee, Hyunseung Lee, Jinhee Kim, Suhyun Lee, Soo Jung Kim, Byong-Seok Choi, Soon-Sun Hong, and Sungwoo Hong, Development and Biological Evaluation of Potent and Selective c-KITD816V Inhibitors, Journal of Medicinal Chemistry [In press], 2014 Kyungeun Lim, Meehyein Kim, Mi-Kyung Lee, Junsang Ko, Sungwoo Hong, Byong-Seok Choi, Biophysical characterization of sites of host adaptive mutation in theinfluenza A virus RNA polymerase PB2 RNA-binding domain, Int. J. Biochem. Cell Biol. [In press], 2014 Seongchan Kim, Soo-Ryoon Ryoo, Hee-Kyung Na, Young-Kwan Kim, Byong-Seok Choi, Younghoon Lee, Dong-Eun Kim and Dal-Hee Min, Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells, Chem. Commum. Vol.49, pp.8241-8243, 2013 Hongje jang, Soo-Ryoon Ryoo, Young-Kwan Kim, Soojin Yoon, Henna Kim, SangpWoo Han, Byong-Seok Choi, Dong-Eun Kim, Dal-Hee Min, Discovery of Highly Selective Hepatitis C Virus NS3 Helicase Inhibitors by a Multiplexed, High-throughput Helicase Activity Assay Based on Graphene Oxide, Angewandte Chemie - International Edition , Vol.52, pp.2340-2344, 2013 Dinan Liu, Kyoung-Seok Ryu, JunsangKo, Dawei Sun, Kyungeun Lim, Jie-Oh Lee, Jung me Hwang, Zee-won Lee, Byong-Seok Choi, Insights into the regulation of human Rev1 for translesion synthesis polymerases revealed by the structural studies on its polymerase-interacting domain, J. Mol. Cell. Biol.,Vol.5, pp.204-206, 2013 Seong Ok Kim, Hyerim Yoon, Seong Oak Park2, Miju Lee3, Jae-Sun Shin1,6, Kyoung-Seok Ryu, Jie-Oh Lee,Yeon-soo Seo, Hyun Suk Jung, Byong-Seok Choi, Srs2 possesses a non-canonical PIP box in front of its SBM for precise recognition of SUMOylated PCNA, J.Mol.Cell Biol. Vol.4, pp.258-261, 2012 Jae-Sun Shin, Kwang-Sun Kim, Kyoung-Seok Ryu, Kook Han,Younghoon Lee, and Byong-Seok Choi, Structural analysis of Escherichia coli C5 protein, PROTEINS, Vol.80, pp.963-967, 2012 Henna Kim, Mi-Kyung Lee, Junsang Ko, Chin-Ju Park, Meeyyein Kim, Yujeong Jeong, Sungwoo Hong, Gabriele Varani, Byong-Seok Choi, Aminoglycoside antibiotics bind to the infiuenza A virus RNA promoter, Molecular Biosystems, Vol.8, pp.2857-2859, 2012 Ae-Ree Lee, Hee-Eun Kim, Yeon-Mi Lee, Minjee Jeong, Kwang-Ho Choi, Jin-Wan Park, Yong-Geun Chioi, Hee-Chul Ahn, Byong-Seok Choi, Joon-Hwa Lee, NMR dynamics study of the Z-DNA binding dimain of human ADAR1 bound to various DNA duplexes, BIOCHEM BIOPH RES CO, Vol.428, pp.137-141, 2012 Yeon-Mi Lee, Hee-Eun Kim, Chin-Ju Park, Ae-Ree Lee, Hee-Chul Ahn, Sung Jae Cho, Kwang-Ho Choi, Byong-Seok Choi, and Joon-Hwa Lee, NMR study on the B-Z junction formation of DNA duplexes induced by ADAR1, J. Am. Chem. Soc., Vol.134, pp.5276-5283, 2012 Young Mee Kim and Byong Seok Choi, Structural and Functional Characterization of the N-terminal Domain of Human Rad51D, Int J Biochem Cell Biol. Vol.43, pp.416-22, 2011 Jae-Sun Shin, Kyoung-Seok Ryu, Junsang Ko, Arum Lee, and Byong-Seok Choi, Structural characterization reveals that a PilZ domain protein undergoes substantial conformational change upon binding to c-di-GMP, Protein Science, Vol.20, pp. 270-7, 2011 Hee-Eun Kim, Hee-Chul Ahn, Yeon-Mi Lee, Eun-Hae Lee, Yeo-Jin Seo, Yang-Gyun Kim,Kyeong Kyu Kim, Byong-Seok Choi, Joon-Hwa Lee, The Zβ domain of human DAI binds to Z-DNA via a novel B-Z transition pathway., FEBS Letters, Vol.585, pp. 772-8, 2011 Ko J, Ryu KS, Kim H, Shin JS, Lee JO, Cheong C, Byong-Seok Choi, Structure of PP4397 reveals the molecular basis for different c-di-GMP binding modes by PilZ domain proteins., J Mol Biol. Vol. 398, pp. 97-110, 2010 Yun-Seok Choi, Kenneth Wu, Kwiwan Jeong, Daeyoup Lee, Young Ho Jeon, Byong-Seok Choi, Zhen-Qiang Pan, Kyoung-Seok Ryu1, and Chaejoon Cheong, The human Cdc34 carboxyl terminus contains a non-covalent ubiquitin binding activity that contributes to SCF-dependent ubiquitination., J Biol Chem.,Vol.285, pp.17754-17762, 2010 Seikh Imtiaz Ali, Jae-Sun Shin, Sung-Hun Bae, Byoungkook Kim, Byong-Seok Choi, Replication protein A 32 interacts through a similar binding interface with TIPIN, XPA, and UNG2, Int J Biochem Cell Biol. Vol.42, pp. 1210-1215, 2010 Eun Hae Lee,Yeo Jin Seo,Hee Chul Ahn,Young Min Kang,Hee Eun Kim,Yeon Mi Lee,Byong Seok Choi and Joon Hwa Lee, NMR study of hydrogen exchange during the B-Z transition of a DNA duplex induced by the Zα domains of yatapoxvirus E3L., FEBS Letters,Vol.584, pp.4453-4457, 2010