个人简介

Education 1980: B.S. Seoul National University 1982: M.S. Seoul National University 1988: Ph.D. Stanford University 1988-1990: Post-Doc. Columbia University 1990-1994: Senior Research Chemist, Merck Research Labs. 1994-Present: Professor, KAIST

研究领域

Organic chemistry

Research topics Development of new reactions and synthetic strategies Total synthesis of natural products Tools for chemical biology Medicinal chemistry

近期论文

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ROSics: Chemistry and proteomics of cysteine modifications in redox biology. Kim, Hee-Jung; Ha, Sura; Lee, Hee-Yoon; Lee, Kong-Joo. Mass Spectrometry Reviews (2015), 34(2), 184-208. Tissue-based metabolic labeling of polysialic acids in living primary hippocampal neurons. Kang, Kyungtae; Joo, Sunghoon; Choi, Ji Yu; Geum, Sujeong; Hong, Seok-Pyo; Lee, Seung-Yeul; Kim, Yong Ho; Kim, Seong-Min; Yoon, Myung-Han; Nam, Yoonkey; Lee, Kyung-Bok; Lee, Hee-Yoon; Choi, Insung S.; Proceedings of the National Academy of Sciences of the United States of America (2015), 112(3), E241-E248. Total synthesis of (-)-crinipellin A. Kang, Taek; Lee, Hee-Yoon. Strategies and Tactics in Organic Synthesis (2014), 10, 271-291. Preparation of benzene derivatives as UCH-L1 inhibitors. Lee, Kong-Joo; Kim, Youhwa; Kim, Hyun Jung; Lee, Hee-Yoon; Joung, Seewon; Jeong, Jae Eun; Seo, Eun-Kyoung. PCT Int. Appl. (2014), WO 2014185561 A1 20141120. Stereospecific mechanism of DJ-1 glyoxalases inferred from their hemithiacetal-containing crystal structures. Choi, Dongwook; Kim, Jihong; Ha, Sura; Kwon, Kyu; Kim, Eun-Hee; Lee, Hee-Yoon; Ryu, Kyoung-Seok; Park, Chankyu. The FEBS journal (2014), 281(24), 5447-62. Sulfhydryl-Specific Probe for Monitoring Protein Redox Sensitivity. Lee, Jae-Jin; Ha, Sura; Kim, Hee-Jung; Ha, Hyun Joo; Lee, Hee-Yoon; Lee, Kong-Joo. ACS Chemical Biology (2014), 9(12), 2883-2894. Total synthesis of (-)-crinipellin A. Taek Kang, Seog Boem Song, Won-Yeob Kim, Byung Gyu Kim, and Hee-Yoon Lee. Journal of the American Chemical Society (2014), 136, 10274-10276. Total synthesis of panaginsene with structural revision. Sujeong Geum and Hee-Yoon Lee. Organic Letters (2014), 16, 2466-2469. Correlation between Functionality Preference of Ru Carbenes and exo/endo Product Selectivity for Clarifying the Mechanism of Ring-Closing Enyne Metathesis. Lee, Ok Suk; Kim, Kyung Hwan; Kim, Jinwoo; Kwon, Kuktae; Ok, Taedong; Ihee, Hyotcherl; Lee, Hee-Yoon; Sohn, Jeong-Hun. Journal of Organic Chemistry (2013), 78, 8242-8249. Chemical Control of Yeast Cell Division by Cross-Linked Shells of Catechol-Grafted Polyelectrolyte Multilayers. Lee, Juno; Yang, Sung Ho; Hong, Seok-Pyo; Hong, Daewha; Lee, Haeshin; Lee, Hee-Yoon; Kim, Yang-Gyun; Choi, Insung S. Macromolecular Rapid Communications (2013), 34, 1351-1356. An asymmetric total synthesis of (+)-pentalenene. Kim, Yoon-Jung; Yoon, Yeokwon; Lee, Hee-Yoon. Tetrahedron (2013), 69, 7810-7816. Aziridinyl imines in organic synthesis: development of tandem reaction strategies and application to total synthesis of natural products. Lee, Hee-Yoon; Song, Seog-Beom; Kang, Taek; Kim, Yoon Jung; Geum, Su Jeong; IUPAC Commission. Pure and Applied Chemistry (2013), 85, 741-753. Total Synthesis of Ceratopicanol through Tandem Cycloaddition Reaction of a Linear Substrate. Lee, Sang-Shin; Kim, Won-Yeob; Lee, Hee-Yoon. Chemistry - An Asian Journal (2012), 7, 2450-2456. A Formal Total Synthesis of Dysiherbaine and Neodysiherbaine. Lee, Hee-Yoon; Lee, Sang-Shin; Kim, Hoon Seok; Lee, Kang Mun. European Journal of Organic Chemistry (2012), 22, 4192-4199. Soluble epoxide hydrolase activity determines the severity of ischemia-reperfusion injury in kidney. Lee, Jung Pyo; Yang, Seung Hee; Lee, Hee-Yoon; Kim, Bora; Cho, Joo-Youn; Paik, Jin Ho; Oh, Yung Jung; Kim, Dong Ki; Lim, Chun Soo; Kim, Yon Su. PLoS One (2012), 7, e37075. 6-Diazohexa-1,2-diene multi-purpose building blocks of consecutive cyclization. Gang, Taek; Geum, Su-Jeong; Kim, Yoon-Jung; Lee, Hee-Yoon. Hwahak Sekye (2012), 52, 21-24. MBIT (Mass Balanced Isotope Tag) labeling agents for performing simultaneous quantitative analysis of multiple proteins and the other biomolecules by mass spectrometry. Shin, Seung Koo; Yoon, Hye Joo; Jung, Yong Sik; Lee, Hee-Yoon; Suh, Min Soo; Seo, Jong Cheol. PCT Int. Appl. (2012), WO 2012026743 A2 20120301. Tandem Cycloaddition Reactions of Allenyl Diazo Compounds Forming Triquinanes via Trimethyleneme-thane Diyls. Kang, Taek; Kim, Won-Yeob; Yoon, Yeokwon; Kim, Byung Gyu; Lee, Hee-Yoon. Journal of the American Chemical Society (2011), 133(45), 18050-18053 A facile synthesis of (S)-felodipine. Kwon, Kuktae; Shin, Jung A.; Lee, Hee-Yoon. Tetrahedron (2011), 67(52), 10222. Unexpected Formation of a trans-syn-Fused Linear Triquinane from a Trimethylenemethane (TMM)-Diyl-Mediated [2+3] Cycloaddition Reaction. Kim, Won-Yeob; Kim, Byung Gyu; Kang, Taek; Lee, Hee-Yoon. Chemistry-An Asian Journal (2011), 6(8), 1931-1935.