个人简介

Education B.S. Seoul National University (1976) M.S. Seoul National University (1978) Ph.D. University of Missouri (1984) Career 1978-1980 Research Scientist, KIST 1984-1986 Postdoc., Cornell University 1986-1989 Assistant Professor, Chonbuk National University 1989-present professor, Department of Chemistry, KAIST Academes and Society (Awards) Korean Chemical Society Korean Society of Biochemistry and Molecular Biology Korean Society of Molecular and Cellular Biology RNA Society

研究领域

Biochemistry

In the cell, messenger RNA (mRNA) is a class of RNA molecules, well known as the protein-coding information carrier. The cell also has noncoding RNA (ncRNA) molecules, such as tRNA and rRNA. In recent years, many ncRNAs have been found from bacteria to mammals. ncRNAs are a versatile class of molecules involved in various cellular metabolisms by functioning as housekeeping or regulatory molecules on the RNA level. Our interests lie in elucidating their functional mechanisms and regulatory strategies to control cellular metabolism through them. Our research is also pursuing to identify the pathological mechanisms of metabolic disorders related to defects in RNA metabolism. Research topics Functional analysis of noncoding RNAs Mechanisms governing regulation of RNA synthesis and degradation RNA metabolism related to diseases

近期论文

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Ji Hun Park, Kyunghwan Kim, Juno Lee, Ji Yu Choi, Daewha Hong, Sung Ho Yang, Frank Caruso, Younghoon Lee, Insung S. Choi (2014) "A Cytoprotective and Degradable Metal-Polyphenol Nanoshell for Single-Cell Encapsulation; Angewandte Chemie International Edition. doi: 10.1002/anie.201405905 Jieon Lee, Il-Soo Park, Euihan Jung, Younghoon Lee, Dal-Hee Min (2014) "Direct, sequence-specific detection of dsDNA based on peptide nucleic acid and graphene oxide without requiring denaturation; Biosensors and Bioelectronics. 62: 140-144 Shinae Suk, Yuna Kim, Geunu Bak, Younghoon Lee (2014) "Identification of a Temperature-Sensitive Mutation in the ribE Gene of an Escherichia coli Keio Collection Strain; Bulletin of the Korean Chemical Society. 35(7): 2175-2178 Minji Sim, Boram Lim, Se-Hoon Sim, Daeyoung Kim, Euihan Jung, Younghoon Lee, Kangseok Lee (2014) "Two Tandem RNase III Cleavage Sites Determine betT mRNA Stability in Response to Osmotic Stress in Escherichia coli; PLOS One. 9(6): e100520 Euihan Jung, Jungmin Lee, Hyo Jeong Hong, Insoo Park, and Younghoon Lee (2014) "RNA recognition by a human antibody against brain cytoplasmic 200 RNA.; RNA. 20(6): 805-814 Wooseok Song, Yong-Hak Kim, Se-Hoon Sim, Soonhye Hwang, Jung-Hyun Lee, Younghoon Lee, Jeehyeon Bae, Jihwan Hwang, Kangseok Lee (2014) "Antibiotic stress-induced modulation of the endoribonucleolytic activity of RNase III and RNase G confers resistance to aminoglycoside antibiotics in Escherichia coli; Nucleic Acids Research. 42(7): 4669-4681 Jin Hyo Kim, Han-Ok Lee, Yong-Joon Cho, Jeongmi Kim, Jongsik Chun, Jaehyuk Choi, Younghoon Lee, Won Hee Jung (2014) "A Vanillin Derivative Causes Mitochondrial Dysfunction and Triggers Oxidative Stress in Cryptococcus neoformans; PLOS One. 9(2): e89122 Hyun-Sook Choi, Hana Kim, Changgook Lee, Youngmi Kim, and Younghoon Lee (2014) "Protein-Protein Interaction between Poly(A) Polymerase and Cyclophilin A in Chemotactic Cells; Bulletin of the Korean Chemical Society. 35(1): 83-86 Geunu Bak, Kook Han, Daun Kim, and Younghoon Lee (2014) "Roles of rpoS-activating small RNAs in pathways leading to acid resistance of Escherichia coli" MicrobiologyOpen. 3(1): 15-28 Yang Won Lee, Shin Yung Lee, Younghoon Lee, and Won Hee Jung (2013) "Evaluation of expression of lipases and phospholipases of Malassezia restricta in patients with seborrheic dermatitis" Annals of Dermatology. 25(3): 310-314 Ji Young Lee, Hongmarn Park, Geunu Bak, Kwang-sun Kim, Younghoon Lee (2013) "Regulation of transcription from two ssrS promoters in 6S RNA biogenesis" Molecules and Cells. 36(3): 227-234 Seongchan Kim, Soo-Ryoon Ryoo, Hee-Kyung Na, Young-Kwan Kim, Byong-Seok Choi, Younghoon Lee, Dong-Eun Kim, and Dal-Hee Min (2013) "Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells" Chemical Communications. 49: 8241-8243 Changgook Lee, Younghoon Lee, Jae-Gon Lee, Alan J. Buglass (2013) "Development of a simultaneous multiple solid-phase microextraction-single shot-gas chromatography/mass spectrometry method and application to aroma profile analysis of commercial coffee" Journal of Chromatography A. 1295: 24-41 Soo-Ryoon Ryoo, Jieon Lee, Jinah Yeo, Hee-Kyung Na, Young-Kwan Kim, Hongje Jang, Jung Hyun Lee, Sang Woo Han, Younghoon Lee, Vic Narry Kim, Dal-Hee Min (2013) "Quantitative and multiplexed microRNA sensing in living cells based on peptide nucleic acid and nano graphene oxide (PANGO)" ACS Nano. 7(7): 5882-5891 Hee-Kyung Na, Mi-Hee Kim, Jieon Lee, Young-Kwan Kim, Hongje Jang, Kyung Eun Lee, Hyerim Park, Won Do Heo, Hyesung Jeon, Insung S. Choi, Younghoon Lee, Dal-Hee Min (2013) "Cytoprotective effects of graphene oxide for mammalian cells against internalization of exogenous materials" Nanoscale. 5(4): 1669-1677 Hongmarn Park, Geunu Bak, Sun Chang Kim, Younghoon Lee (2013) "Exploring sRNA-mediated gene silencing mechanisms using artificial small RNAs derived from a natural RNA scaffold in Escherichia coli" Nucleic Acids Research. 41(6): 3787-3804 Jeongmi Kim, Yong-Joon Cho, Eunsoo Do, Jaehyuk Choi, Guanggan Hu, Brigitte Cadieux, Jongsik Chun, Younghoon Lee, James W. Kronstad, Won Hee Jung (2012) "A defect in iron uptake enhances the susceptibility of Cryptococcus neoformans to azole antifungal drugs" Fungal Genetics and Biology. 49(11): 955-966 Sang Hoon Yun, Sang Chun Ji, Heung Jin Jeon, Xun Wang, Si Wouk Kim, Geunu Bak, Younghoon Lee, Heon M. Lim (2012) "The CnuK9E H-NS complex antagonizes DNA binding of DicA and leads to temperature-Dependent filamentous growth in E. coli" PLoS One. 7(9): e45236 Jae-Sun Shin, Kwang-Sun Kim, Kyoung-Seok Ryu, Kook Han, Younghoon Lee, Byong-Seok Choi (2012) "Structural analysis of Escherichia coli C5 protein" Proteins: Structure, Function, and Bioinformatics. 80(3): 963-967 Soo-Ryoon Ryoo, Hongje Jang, Ki-Sun Kim, Bokhui Lee, Kyung Bo Kim, Young-Kwan Kim, Woon-Seok Yeo, Younghoon Lee, Dong-Eun Kim, Dal-Hee Min (2012) "Functional delivery of DNAzyme with iron oxide nanoparticles for hepatitis C virus gene knockdown" Biomaterials. 33(9): 2754-2761