Tan, Choon Hong - Nanyang Technological University - Division of Chemistry and Biological Chemistry

个人简介

Professional Experience Jan 2018 - Present Chair, School of Physical and Mathematical Sciences, Division of Chemistry and Biological Chemistry, Nanyang Technological University Aug 2016 Professor, School of Physical and Mathematical Sciences, Division of Chemistry and Biological Chemistry, Nanyang Technological University Apr 2012 Associate Professor, School of Physical and Mathematical Sciences, Division of Chemistry and Biological Chemistry, Nanyang Technological University CN Yang Scholars Programme Director (Oct 2013 - present) Associate Chair, Outreach and Undergraduate Admissions (Jan 2013 - May 2014) 2003 - 2010 Assistant Professor, Department of Chemistry, National University of Singapore 2010 - Mar 2012 Associate Professor, Department of Chemistry, National University of Singapore Dean's Chair Professor (2011 - 2012) 2002 - 2003 Research Associate (Supervisor: Prof. Robert R. Rando), Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School 2000 - 2002 Postdoctoral Fellow (Supervisor: Prof. Yoshito Kishi), Department of Chemistry and Chemical Biology, Harvard University Educational Background 1996 - 1999 PhD, University of Cambridge(Supervisor: Prof. Andrew B. Holmes) 1994 - 1995 B. Sc. (Hons), First Class, National University of Singapore 1991 - 1994 B. Sc., National University of Singapore

研究领域

Synthetic Organic Chemistry Adventures into Phase Transfer Catalysis Halogen Bonding in Catalysis Ion-Pair Catalysis Chemical Biology Synthetic Water Channel for desalination Membranes Development of Next-Generation Antibiofilm Drugs

近期论文

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K. F. Chin, X. Ye, Y. Li, R. Lee, A. M. Kabylda, D. Leow, X. Zhang, E. C. X. Ang and C.-H. Tan, Bisguanidinium-Catalyzed Epoxidation of Allylic and Homoallylic Amines under Phase Transfer Conditions, ACS Catalysis, 2020, 10, 4, 2684 – 2691. J. Ren, X. Ban, X. Zhang, S. M. Tan, R. Lee and C.-H. Tan, Kinetic and Dynamic Kinetic Resolution of Racemic Tertiary Bromides by Pentanidium-Catalyzed Phase-Transfer Azidation, Angewandte Chemie International Edition, 2020, 59, 9055-9058. E. C. X. Ang, C.-H. Tan, Golden Jubilee of Singapore National Institute of Chemistry (1970-2020): Celebrating Its Partnership with Wiley-VCH. Angewandte Chemie International Edition, 2020, 59 (45), 19728 – 19731. E. C. X. Ang, X. Ye, C.-H. Tan, Preparation of Asymmetric Phase-Transfer Catalyst, 1,4-Bis((4S,5S)-1,3-Bis(3,5-Di-Tert-Butylbenzyl)-4,5-Diphenylimidazolidin-2-Ylidene)Piperazine-1,4-Diium Chloride. Organic Syntheses, 2020, 97, 274 – 293. W. Chen, E. C. X. Ang, S. M. Tan, Z. Chua, J. Ren, Z. Yang, B. Teng, R. Lee, H. Lu, C.-H. Tan, Enantioselective Addition-Alkylation Of Α,Β-Unsaturated Carbonyls Via Bisguanidinium Silicate Ion Pair Catalysis. Journal of the American Chemical Society 2020, 142 (45), 19065 – 19070. X. Zhang and C.-H. Tan, Stereospecific and stereoconvergent nucleophilic substitution reactions at tertiary carbon centers, Chem 7, 1–36, June 10, 2021. X. Zhang, J. Ren, S. M. Tan, D. Tan, R. Lee, C.-H. Tan, Enantioconvergent Halogenophilic Nucleophilic Substitution (SN2X) Reaction, Science, 2019, 363, 400 – 404. Q. Li, X. Li, L. Ning, C.-H. Tan, Y. Mu, R. Wang, Hyperfast water transport through biomimetic nanochannels from peptide-attached (pR)-pillar[5]arene, Small., 2019, 15, 1804678. Y.-C. Gordon Ge, X.-Y. Cui, H. Jiang, J.-Y. Ren, Nicholas Lee, C.-H. Tan, Guanidine–Copper Complex Catalyzed Allylic Borylation for the Enantioconvergent Synthesis of Tertiary Cyclic Allylboronates, Angewandte Chemie International Edition, 2019, 58, 2382 – 2386. Nicholas Lee, D.S. Leow, C.-H. Tan, Enantiospecific and Enantioselective Brook Rearrangements, Asian Journal of Organic Chemistry, 2019, 8, 25 – 31. July Fong, K. T. Mortensen, A. Nørskov, K. Qvortrup, L. Yang, C. H. Tan, T. E. Nielsen, M. Givskov, Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa, Frontiers in Cellular and Infection Microbiology, 2019, 8, 443. Valerie H. L. Wong, C.-H. Tan, Y. H. Lim, Copper-mediated [11C]Formylation of Amines using [11C]CO2 and radiosynthesis of 2-[11C]-Heterocycles, ChemComm., 2019, submitted. X.-Y. Cui, D. Leow, C.-H. Tan, Metal-Catalysed Reactions Enabled by Guanidine-Type Ligands, Organic and Biomolecular Chemistry, 2019, 17, 4689 – 4699. H.-C. Chou, D. Leow and C.-H. Tan, Recent Advances in Chiral Guanidine-Catalyzed Enantioselective Reactions, Asian Journal of Organic Chemistry, 2019, 14, 3803 – 3822. W. Cao, D. Tan, R. Lee, C.-H. Tan, Enantioselective 1,2-Anionotropic Rearrangement of Acylsilane through Bisguanidinium Silicate Ion Pair, Journal of the American Chemical Society, 2018, 140, 1952 – 1955. M.-Y. Jin, Y. R. Liao, C.-H. Tan, R. Wang, Development of high performance nanofibrous composite membranes by optimizing polydimethylsiloxane architectures for phenol transport, Journal of Membrane Science, 2018, 549, 638 – 648. X.-Y. Cui, Y. Ge, H. Jiang, Davin Tan, Yunpeng Lu, Richmond Lee, C.-H. Tan, (Guanidine)copper Complex-Catalysed Dynamic Kinetic Allylic Alkynylation Under Biphasic Conditions, Journal of the American Chemical Society, 2018, 140, 8448 − 8455. (Highlighted by Synfacts 2018, 5, 14(09), 0949; contributors: Mark Lautens, Andrew Whyte) Y. Liang, D. Zeng, X. Huang, L. Chan, C. Mei, P. Feng, C.-H.Tan, T. Chen, Cancer-targeted Design of Bioresponsive Prodrug with Enhanced Cellular Uptake for Precise Cancer Therapy, Drug Delivery, 2018, 25, 1350 – 1361. M.-Y. Jin, Y. Liao, Y. Lin, C.-H. Tan, R. Wang, Development of Highly-Efficient ZIF-8@PDMS/PVDF Nanofibrous Composite Membrane for Phenol Removal in Aqueous-Aqueous Membrane Extractive Process, Journal of Membrane Science, 2018, 568, 121 – 133. Repurposing the anti-cancer drug cisplatin as an effective Pseudomonas aeruginosa infection control agent, M. Yuan, S. L. Chua, Yang Liu, D. I. Drautz-Moses, J. K. H. Yam, T. T. Aung, R. W. Beuerman, M. M. S. Salido, S. C. Schuster, C.-H. Tan, M. Givskov, L. Yang, T. E. Nielsen, Beilstein Journal of Organic Chemistry, 2018, 14, 3059 – 3069.