Arnold, Frances H - California Institute of Technology, Caltech - Division of Chemistry and Chemical Engineering

个人简介

B.S., Princeton University, 1979; Ph.D., University of California, 1985. Visiting Associate, Caltech, 1986; Assistant Professor of Chemical Engineering, 1987-92; Associate Professor, 1992-96; Professor, 1996-99; Professor of Chemical Engineering and Biochemistry, 1999-2000. Linus Pauling Professor, 2000-; Director, Rosen Bioengineering Center, 2013-.

研究领域

Research in the Arnold group focuses on evolutionary protein design methods (1,2) and using the results of laboratory evolution experiments to elucidate principles of biological design. We generate novel and useful enzymes and organisms for applications in medicine, neurobiology, chemical synthesis and alternative energy. We also construct entire synthetic families of enzymes and other proteins in order to study structure-function relationships free from constraints of natural selection. This research requires contributions from many disciplines, including chemistry, bioengineering, biochemistry, molecular biology, microbiology, chemical engineering, chemistry and applied physics.

近期论文

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“Protein Sequence Design with Deep Generative Models” Z. Wu, K. E. Johnston, & F. H. Arnold. Curr. Opin. in Chem. Biol. December, 2021. 10.1016/j.cbpa.2021.04.004. “Dual-function enzyme catalysis for enantioselective carbon–nitrogen bond formation” Z. Liu, C. Calvó-Tusell, A. Z. Zhou, K. Chen, M. Garcia-Borràs & F. H. Arnold. Nat. Chem. October 18, 2021. 10.1038/s41557-021-00794-z. “Biocatalytic, Intermolevular C-H Bond Functionalization for the Synthesis of Enantioenriched Amides” S. Athavale, S. Gao, Z. Liu, S. C. Mallojjala, J. Hirschi, F. H. Arnold. Angew. Chemie. September 17, 2021. 10.1002/ange.202110873. “Informed training set design enables efficient machine learning-assisted directed protein evolution” B. J. Wittmann, Y. Yue, & F. H. Arnold. Cell Syst. August 19, 2021. 10.1016/j.cels.2021.07.008. “Advances in Machine Learning for Directed Evolution” B. J. Wittmann, K. E. Johnston & F. H. Arnold. Curr. Opin. in Struct. Biol. August, 2021. 10.1016/j.sbi.2021.01.008. “Asymmetric Alkylation of Ketones Catalyzed by Engineered TrpB” E. J. Watkins-Dulaney, N. P. Dunham, S. Straathof, S. Turi, & F. H. Arnold. Angew. Chemie. July 15, 2021. 110.1002/anie.202106938. “Biocatalytic Transformations of Silicon—the Other Group 14 Element” N. S. Sarai, B. J. Levin, J. M. Roberts, D. E. Katsoulis & F. H. Arnold. ACS Cent. Sci.. May 7, 2021. 10.1021/acscentsci.1c00182. “Origin and Control of Chemoselectivity in Cytochrome c Catalyzed Carbene Transfer into Si–H and N–H bonds” M. Garcia-Borràs, S. B. J. Kan, R. D. Lewis, A. Tang, G. Jimenez-Osés, F. H. Arnold, and K. N. Houk J. Am. Chem. Soc.. April 28, 2021. 10.1021/jacs.1c02146. “Navigating the Unnatural Reaction Space: Directed Evolution of Heme Proteins for Selective Carbene and Nitrene Transfer” Y. Yang & F. H. Arnold. Acc. Chem. Res.. Jan 25, 2021. 10.1021/acs.accounts.0c00591. “New-to-nature chemistry from old protein machinery: carbene and nitrene transferases” Z. Liu & F. H. Arnold. Curr. Op. in Biotech. Dec 25, 2020. 10.1016/j.copbio.2020.12.005. “High Throughput Screening with SAMDI Mass Spectrometry for Directed Evolution” A. J. Pluchinsky, D. J. Wackelin, X. Huang, F. H. Arnold, & M. Mrksich. J.A.C.S. Nov 11, 2020. 10.1021/jacs.0c07828. “Scalable continuous evolution for the generation of diverse enzyme variants encompassing promiscuous activities” G. Rix, E. J. Watkins-Dulaney, P. J. Almhjell, C. E. Boville, F. H. Arnold, & C. C. Liu. Nat. Comm. Nov 6, 2020. 10.1038/s41467-020-19539-6. “Nature’s Machinery, Repurposed: Expanding the Repertoire of Iron-Dependent Oxygenases” N. P. Dunham & F. H. Arnold. ACS Catal. Sept 28, 2020. 10.1021/acscatal.0c03606. “Tryptophan Synthase: Biocatalyst Extraordinaire” E. J. Watkins-Dulaney, S. Straathof, & F. H. Arnold. ChemBioChem. July 16, 2020. 10.1002/cbic.202000379. “Signal Peptides Generated by Attention-Based Neural Networks” Z. Wu, K. Y. Yang, M. Liska, A. Lee, D. Wernick, D. Weiner, & F. H. Arnold. ACS Synth. Bio. July 10, 2020. 10.1021/acssynbio.0c00219. “Diversity-Oriented Enzymatic Synthesis of Cyclopropane Building Blocks” B. J. Wittmann, A. M. Knight, J. Hofstra, S. E. Reisman, S. B. J. Kan, & F. H. Arnold. ACS Catalysis. June 4, 2020. 10.1021/acscatal.0c01888. “Enzymatic Primary Amination of Benzylic and Allylic C(sp3)–H Bonds” Z. J. Jia, S. Gao & F. H. Arnold. J. Am. Chem. Soc. May 25, 2020. 10.1021/jacs.0c03428. “Enzymatic Lactone-Carbene C–H Insertion to Build Contiguous Chiral Centers” A. Z. Zhou, K. Chen & F. H. Arnold. ACS Catalysis. April 21, 2020. 10.1021/acscatal.0c01349. “Engineering Cytochrome P450s for Enantioselective Cyclopropenation of Internal Alkynes” K. Chen & F. H. Arnold. J. Am. Chem. Soc. March 29, 2020. 10.1021/jacs.0c01313. “Selective Enzymatic Oxidation of Silanes to Silanols” S. Bähr, S. Brinkmann-Chen, M. Garcia-Borràs, J. M. Roberts, D. E. Katsoulis, K. N. Houk, F. H. Arnold. Angewandte Chemie. March 24, 2020. 10.1002/anie.202002861.