个人简介

1979 B.S. Kyoto Univ. Department of Synthetic Chemistry. 1981 M.S. Kyoto Univ. Department of Synthetic Chemistry. 1984 Ph.D. Kyoto Univ. Department of Synthetic Chemistry. 1984 Research Associate at University of Virginia (USA). 1986 Research Associate at Kyoto University. 1987 Assistant Professor, Kyoto Univ. Department of Synthetic Chemistry. 1993 Associate Professor, Kyoto Univ. Department of Synthetic Chem. & Biological Chem. 1996 Professor, Tokyo Medical & Dental Univ. Institute of Biomaterials & Bioengineering. 2003 Professor, Kyoto Univ. Graduate School of Science, Department of Chemistry. 2008 Principal Investigator, Institute for Integrated Cell-Material Sciences (iCeMS). IBM Japan Science Award (1999) The CSJ Award for Creative Work (2005) Editorial Advisory Board of ChemBioChem. (2005) Editorial Advisory Board of J. Am. Chem. Soc. (2009) Editional Board of J. Nucleic Acids. (2009) Editorial Advisory Board of J. Med. Chem. (2011) Editorial Board of The Chemical Record (2011) Associate Editor of Biomaterials Science (2012)

研究领域

Chemical Biology/Bioorganic Chemistry

Chemistry of nucleic acid structure and function Development of tailor made antitumor agent Development of artificial genetic switch Development of DNA origami for single molecule analysis

近期论文

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Tandem Trimer Pyrrole-Imidazole Polyamide Probes Targeting 18 Base Pairs in Human Telomere Sequence Kawamoto, Y.; Sasaki, A.; Hashiya, K.; Ide, S; Toshikazu, B.; Maeshima, K; Sugiyama, H. Chem. Sci. In Press. Rational Design of Specific Binding Hairpin Py-Im Polyamides Targeting Human Telomere Sequences Guo, C, X .; Kawamoto, Y.; Asamitsu, S.; Sawatani, Y.; Hashiya, K.; Toshikazu, B.; Sugiyama, H. Bioorg. Med. Chem. 2015, 23, 855-860. Advancing Small-Molecule-Based Chemical Biology With Next-Generation Sequencing Technologies Anandhakumar, C.; Kizaki, S.; Bando, T.; Pandian, G. N.; Sugiyama, H. ChemBioChem. 2015, 16, 20-38. Synthetic Strategies to Identify and Regulate Noncoding RNAs Pandian, G, N.; Syed, J.; Sugiyama, H. Long Noncoding RNAs: Structure and Function. In Press. Locating the 2'-Deoxyuridin-5-yl Radical Formed Upon Photoirradiation of 5-bromouracil-substituted DNA Hashiya, F.; Saha, A.; Kizaki, S.; Li, Y.; Sugiyama, H. Nucleic Acids Res. 2014, 42, 13469-13473. Identification of a Small Molecule that Turns `ON` the Pluripotency Gene Circuitry in Human Fibroblasts Pandian, G, N.; Sato, S.; Anandhakumar, C.; Taniguchi, J.; Takashima, K.; Syed, J; Han, L.; Saha, A.; Bando, T.; Nagase, H.; Sugiyama, H. ACS Chem. Biol. 2014, 9, 2729-2736. Direct Quantification of Loop Interaction and π-π Stacking for G-quadruplex Stability at the Sub-molecular Level Ghimire, C.; Park, S.; Iida, K.; Yangyuoru, P.; Otomo, H.; Yu, Z.; Nagasawa, K.; Sugiyama, H.; Mao, H. J. Am. Chem. Soc. 2014, 136, 15537-15544. Preparation of Chemically Modified RNA Origami Nanostructures Endo, M.; Takeuchi, Y.; Emura, T.; Hidaka, K.; Sugiyama, H. Chem. Eur. J. 2014, 20, 15330-15333. Development of DNA-based Hybrid Catalysts Through Direct Ligand Incorpororation: Towards Understanding of DNA-based Asymmetric Catalysis Park, S.; Zheng, L, J.; Kumakiri, S.; Sakashita, S.; Otomo, H.; Ikehata, K.; Sugiyama, H. ACS Catalysis. 2014, 4, 4070-4073. Next-Generation Sequencing Studies Guide the Design of Pyrrole-Imidazole Polyamides with Improved Binding Specifictiy by the Addition of β-alanine Anandhakumar, C.; Li, Y.; Kizaki, S.; Pandian, G, N.; Hashiya, K.; Bando, T.; Sugiyama, H. ChemBioChem. 2014, 15, 2647-2651. Photoresponsive DNA Nanocapsule Having an Open/Close System for Capture and Release of Nanomaterials Takenaka, T.; Endo, M.; Suzuki, Y.; Yang, Y.; Emura, T.; Hidaka, K.; Kato, T.; Mitata, T.; Namba, K.; Sugiyama, H. Chem. Eur. J. 2014, 20, 14951-14954. NanoScript: A Nanoparticle-Based Artificial Transcription Factor for Effective Gene Regulation Patel, S.; Jung, D.; Yin, P.; Carlton, P.; Yamamoto, M.; Bando, T.; Sugiyama, H.; Lee, K, B. ACS Nano. 2014, 8, 8959-8967. Engineering RNA-Protein Complexes with Different Shapes for Imaging and Therapeutic Applications Osada, E.; Suzuki, Y.; Hidaka, K.; Ohno, H.; Sugiyama, H.; Endo, M.; Saito, H. ACS Nano. 2014, 8, 8130-8140. Structure Evaluation of Tandem Hairpin Pyrrole-Imidazole Polyamides Recoginzing Human Telomeres Hirata, A.; Nokihara, K.; Kawamoto, Y.; Bando, T.; Sasaki, A.; Ide, S.; Maeshima, K.; Kasama, T.; Sugiyama, H. J. Am. Chem. Soc. 2014, 136, 11546-11554. Targeted Suppression of EVI1 Oncogene Expression by Sequence-specific Pyrrole-imidazole Polyamide Junetha, S.; Pandian, G, N.; Sato, S.; Taniguchi, J.; Anandhakumar, C.; Hashiya, K.; Bando, T.; Sugiyama, H. Chem. Bio. 2014, 23, 1370-1380. Amplification of Fluorescent DNA through Enzymatic Incorporation of a Highly Emissive Deoxyguanosine Analogue Otomo, H.; Park, S.; Yamamoto, S.; Sugiyama, H. RSC Adv. 2014, 4, 31341-31344. Sequence-Specific DNA Alkylation and Transcriptional Inhibition by Long-Chain Hairpin Pyrrole-Imidazole Polyamide-Chlorambucil Conjugates Targeting CAG/CTG Trinucleotide Repeats. Asamitsu, S.; Kawamoto, Y.; Hashiya, F.; Hashiya, K.; Yamamoto, M.; Kizaki, S.; Bando, T.; Sugiyama, H. Bioorg. Med. Chem 2014, 22, 4646-4657. AFM Analysis of Changes in Nucleosome Wrapping Induced by DNA Epigenetic Modification Kizaki, S.; Suzuki, Y.; Takenaka, T.; Endo, M.; Sugiyama, H. Biomater. Sci. 2014, 2, 1399-1403. Chemically Modified Synthetic Small Molecule Boosts its Biological Efficacy against Pluripotency Genes in Mouse Fibroblast Saha, A.; Pandian, G. N.; Sato, S.; Taniguchi, J.; Kawamoto, Y.; Hashiya, K.; Bando, T.; Sugiyama, H. ChemMedChem 2014, 9, 2374-2380. Single Molecule Mechanochemical Sensing Using DNA Origami Nanostructures Koirala, D.; Shrestha, P.; Emura, T; Hidaka, K.; Mandal, S.; Endo, M,; Sugiyama, H.; Mao, H. Angew. Chem. Int. Ed. 2014, 126, 8275-8279.