Hutcheon, Gillian - Liverpool John Moores University - School of Pharmacy and Biomolecular Sciences

个人简介

I am leader of the Formulation and Drug Delivery Research Group. The focus of this group is towards the successful delivery of therapeutic agents in a controlled and targeted manner and the development of advanced delivery systems for a variety of applications. Projects ranging from fundamental science to industrially relevant applications are undertaken by postgraduate students and researchers within the group. My research interests include the use of biodegradable polymers for the micro and nanoparticle delivery of drugs and proteins particularly for pulmonary delivery. Specific examples of ongoing projects include the delivery of vaccines, anti-cancer drugs and RNA. The investigation of clays for antimicrobial and modified release therapeutics is a further avenue of research. I contribute towards the modular delivery of general chemistry, bio-organic chemistry, polymer chemistry and drug delivery topics. My teaching interests concentrate on the integration of teaching and research particularly within final year module and also the development of the final year ACAPS project and research methods module. Degrees 1996, University of Strathclyde, United Kingdom, PhD: Fundamental studies of protein hydration and solvation in organic media 1993, University of Strathclyde, United Kingdom, B.Sc. (Hons) Forensic and Analytical Chemistry

近期论文

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Mohamed A, Ross K, Saleem IY, Hutcheon GA. 2016. Pulmonary Delivery of Therapeutic miR-146a Nanoparticles. AAPS National Biotechnology Conference, Boston, USA. Mohamed A, Ross K, Saleem IY, Hutcheon GA. 2015. Polymeric Nanoparticles for the Pulmonary Delivery of miRNA to Treat Chronic Obstructive Pulmonary Disease (COPD). 42nd Annual Meeting & Exposition of the Controlled Release Society, Edinburgh. Osman N, Hilal M, Mohamed S, Dawood A, Ritchie K, Saleem I, Hutcheon G. 2016. IN-VITRO STABILITY AND DEGRADATION OF PLGA AND PGA-CO-PDL MICROPARTICLES FOR PULMONARY DRUG DELIVERY JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 29 :A5-A5 >Link kunda N, alfagih I, Alanazi F, hutcheon G, saleem I. 2015. Comparison of Protein Delivery via Nanocomposite Microcarriers for Pulmonary Vaccine Delivery Mohamed A, Ross K, Saleem I, Hutcheon G. 2015. Polymeric Nanoparticles For The Pulmonary Delivery Of miRNA To Treat Chronic Obstructive Pulmonary Disease (COPD) Controlled Release Society Annual Meeting Osman N, Hilal M, Mohamed S, Dawood A, ritchie K, Saleem I, hutcheon G. 2015. In-vitro Stability and Degradation of PLGA and PGA-co-PDL Microparticles for Pulmonary Drug Delivery Drug Delivery to the Lungs Alfagih IM, Kunda NK, Alanazi FK, Hutcheon GA, Saleem IY. 2015. CATIONIC PGA-CO-PDL NANOCOMPOSITE MICROPARTICLES FOR ANTIGEN DELIVERY VIA INHALATION JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 28 :A16-A16 >Link Alfagih I, Kunda N, Alanazi F, Hutcheon G, saleem I. 2014. Cationic PGA-co-PDL nanocomposite microparticles for antigen delivery via inhalation kunda N, Somavarapu S, Gordon SB, Hutcheon G, Saleem I. 2013. Protein Adsorbed PGA-co-PDL Nanocarriers for Vaccine Delivery AAPS Annual Meeting and Exposition kunda NK, Alfagih IM, Somavarapu S, Hutcheon GA, Saleem I. 2012. Pulmonary Vaccine Delivery of Protein Adsorbed PGA-co-PDL Nanocomposite Microparticles Drug Delivery to the Lungs - DDL23 Alfagih IM, Alanazi FK, Kunda NK, Hutcheon GA, Saleem IY. 2012. Protein Loaded PGA-co-PDL Nanocomposite Microparticles for Inhalation Drug Delivery to the Lungs DDL23 Ismail FMD, Tawfeek HM, Hutcheon GA, Saleem IY . 2011. Pulmonary delivery of encapsulated chloroquine phosphate using polyester polymer-based microparticles for potential treatment of lung cancers Journal of Aerosol Medicine and Pulmonary Drug Delivery, 24 :303-334 Tawfeek H, Khidr S, Samy EM, Ahmed SM, Gaskell EE, Hutcheon G, Saleem I. 2010. PGA-co-PDL as a Novel Carrier for Pulmonary Drug Delivery 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology Tawfeek H, Khidr S, Samy E, Ahmed S, Hutcheon G, Saleem I. 2010. Enhancing the Aerosolisation Proprieties of Polyester based Microparticles as Novel Carriers for Dry Powder Inhalation 37th Annual Meeting & Exposition of the Controlled Release Society Tawfeek HM, Khidr SH, Samy EM, Ahmed SM, Akram K, Mohammed AR, Gaskell EE, Hutcheon G, Saleem I. 2010. Optimisation of polyester based microparticles as carriers for pulmonary drug delivery Drug Delivery to the Lungs Tawfeek HM, Khidr SH, Samy EM, Ahmed SM, Evans A, Gaskell EE, Hutcheon GA. 2010. Encapsulation, release, bioactivity and cytotoxicity of lysozyme loaded poly(glycerol adipte-co-omega-pentadecalactone) microparticles JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1431-1432 >Link Khamar D, Seton L, Bradshaw I, Hutcheon G. 2010. Generation and characterisation of new anhydrous polymorph of theophylline JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 :1333-1334 >Link McAllister L, Evans A, Hutcheon G, Gaskell E. 2009. Encapsulation of epirubicin for the treatment of cancer JOURNAL OF PHARMACY AND PHARMACOLOGY, 61 :A82-A82 >Link Iftikhar A, Gaskell E, Hutcheon GA, Rostron C. 2008. The stability of biodegradable polyesters and polyester-co-lactones utilized for drug delivery JOURNAL OF PHARMACY AND PHARMACOLOGY, 60 :A58-A58 >Link Hutcheon GA, Gaskell E, Iftikhar A, Rostron C. 2008. Overcoming the mucin barrier in the treatment of pulmonary cystic fibrosis JOURNAL OF PHARMACY AND PHARMACOLOGY, 60 :A11-A11 >Link Ghazal H, Dyas AM, Ford JL, Hutcheon GA. 2007. The intrinsic dissolution rate of ketoconazole in proteinaceous biorelevant media JOURNAL OF PHARMACY AND PHARMACOLOGY, 59 :A46-A46 >Link Gaskell E, Hobbs G, Rostron C, Hutcheon GA. 2006. Encapsulation of mucinolytic enzymes for treatment of cystic fibrosis JOURNAL OF PHARMACY AND PHARMACOLOGY, 58 :A67-A67 >Link Thompson CJ, Hansford D, Munday DL, Higgins S, Hutcheon GA, Rostron C. 2006. Preparation and characterisation of microspheres of a novel polyester polymer conjugated to ibuprofen JOURNAL OF PHARMACY AND PHARMACOLOGY, 58 :A15-A15 >Link Meng W, Parker TL, Kallinteri P, Hutcheon GA, Higgins S, Walker DA, Walker DA, Garnett MC. 2005. Uptake and drug delivery using biodegradable nanoparticles in monolayers and organotypic brain slices NEURO-ONCOLOGY, 2nd Quadrennial Meeting of the World-Federation-of-Neuro-Oncology/6th Meeting of the European-Association-for-Neur-Oncology 7 :383-384 >Link Puri S, Kallinteri P, Higgins SH, Hutcheon GA, Garnett MC. 2005. Drug incorporation and release from functionalized poly glycerol adipate nanoparticles JOURNAL OF PHARMACY AND PHARMACOLOGY, 57 :S21-S22 >Link