研究领域
Organic
Molecular recognition, self-assembly, organic synthesis, reversible and bio-inspired materials, non-covalent interactions
Research in my laboratory uses organic synthesis, physical organic chemistry, spectroscopic methods, and computation to design, prepare, and study novel organic molecules that show unique and useful behavior. In this context we are particularly interested in predicting and controlling properties that emerge when individual molecules aggregate, by weak noncovalent interactions, in solution. The phenomenon is called "self-assembly," and it is a process borrowed from nature to achieve complexity rapidly and reversibly (e.g., assembly of the DNA duplex or binding of a receptor to its enzymatic target). It is also the central theme of supramolecular chemistry, an established field that studies chemistry "beyond the molecule." Our specific areas of interest and expertise include: stereoelectronic effects in supramolecular chemistry, construction of novel donor-acceptor molecules with useful electronic or optical properties, functional molecules (for materials and/or sensing applications) from biorelevant building blocks, and molecular-based strategies to novel therapeutics.
近期论文
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Ferreira, R. B.; Law, M. E.; Jahn, S. C.; Davis, B. J.; Heldermon, C. D.; Reinhard, M. K.; Castellano, R. K.; Law, B. K. "Novel Agents that Downregulate EGFR, HER2, and HER3 in Parallel", Oncotarget 2015, Advance Online Publication.
Zhao, X.; Watkins, D. L.; Galindo, J.; Shewmon, N. T.; Roitberg, A. E.; Xue, J.; Castellano, R. K.; Perry, S. S. "Hydrogen Bond Directed Assembly of Oligothiophene/Fullerene Superstructures on Au(111)", Org. Electron. 2015, 19, 61–69. DOI
Bou Zerdan, R.; Cohn, P.; Puodziukynaite, E.; Baker, M. B.; Voisin, M.; Sarun, C.; Castellano, R. K. "Synthesis, Optical Properties, and Electronic Structures of Nucleobase-Containing π-Conjugated Oligomers", J. Org. Chem. 2015, 80, 1828–1840. DOI
Castellano, R. K. "Special Issue: Intramolecular Hydrogen Bonding", Molecules 2014, 19, 15783–15785. DOI
Schulze, B. M.; Watkins, D. L.; Zhang, J.; Ghiviriga, I.; Castellano, R. K. "Estimating the Shape and Size of Supramolecular Assemblies by Variable Temperature Diffusion Ordered Spectroscopy", Org. Biomol. Chem. 2014, 12, 7932-7936. DOI
Bou Zerdan, R.; Shewmon, N. T.; Zhu, Y.; Mudrick, J. P.; Chesney, K. J.; Xue, J.; Castellano, R. K. "The Influence of Solubilizing Chain Stereochemistry on Small Molecule Photovoltaics", Adv. Funct. Mater. 2014, 24, 5993–6004. DOI
Schulze, B. M.; Shewmon, N. T.; Zhang, J.; Watkins, D. L.; Mudrick, J. P.; Cao, W.; Bou Zerdan, R.; Quartararo, A. J.; Ghiviriga, I.; Xue, J.; Castellano, R. K. "Consequences of Hydrogen Bonding on Molecular Organization and Charge Transport in Molecular Organic Photovoltaic Materials", J. Mater. Chem. A 2014, 2, 1541–1549. DOI
Yang, Y.; Cohn, P.; Eom, S.-H.; Abboud, K. A.; Castellano, R. K.; Xue, J. "Ultraviolet–violet Electroluminescence from Highly Fluorescent Purines", J. Mater. Chem. C 2013, 1, 2867–2874. DOI
Castellano, R. K.; Li, Y.; Homan, E. A.; Lampkins, A. J.; Marín, I. V.; Abboud, K. A. "Seven-Membered Intramolecular Hydrogen Bonding of Phenols: Database Analysis and Phloroglucinol Model Compounds", Eur. J. Org. Chem. 2012, 2012, 4483–4492. DOI
Baker, M. B.; Ghiviriga, I.; Castellano, R. K. "Molecular Multifunctionalization via Electronically Coupled Lactones", Chem. Sci. 2012, 3, 1095–1099. DOI, Publicity
Mei, J.; Graham, K. R.; Stalder, R.; Tiwari, S. P.; Cheun, H.; Shim, J.; Yoshio, M.; Nuckolls, C.; Kippelen, B.; Castellano, R. K.; Reynolds, J. R. "Self-Assembled Amphiphilic Diketopyrrolopyrrole-Based Oligothiophenes for Field-Effect Transistors and Solar Cells", Chem. Mater. 2011, 23, 2285–2288. DOI
Baker, M. B.; Yuan, L.; Marth, C. J.; Li, Y.; Castellano, R. K. "Rapid Access to C3- and Cs-Symmetric AAT Organogelators via Ring Opening of a Common Benzotrifuranone Precursor", Supramol. Chem. 2010, 22, 789–802. DOI
Yang, Y.; Cohn, P.; Dyer, A. L.; Eom, S.-H.; Reynolds, J. R.; Castellano, R. K.; Xue, J. "Blue-Violet Electroluminescence from a Highly Fluorescent Purine", Chem. Mater. 2010, 22, 3580–3582. DOI
Fraga-Silva, R. A.; Sorg, B. S.; Wankhede, M.; deDeugd, C.; Jun, J. Y.; Baker, M. B.; Li, Y.; Castellano, R. K.; Katovich, M. J.; Raizada, M. K.; Ferreira, A. J. "ACE2 Activation Promotes Antithrombotic Activity", Mol. Med. 2010, 16, 210–215. DOI
Li, Y.; Lampkins, A. J.; Baker, M. B.; Sumpter, B. G.; Huang, J.; Abboud, K. A.; Castellano, R. K. "Benzotrifuranone: Synthesis, Structure, and Access to Polycyclic Heteroaromatics", Org. Lett. 2009, 11, 4314–4317. DOI
Ferreira, A. J. ; Shenoy, V.; Yamazato, Y.; Sriramula, S.; Francis, J.; Yuan, L.; Castellano, R. K.; Ostrov, D. A.; Oh, S. P.; Katovich, M. J. ; Raizada, M. K. "Evidence for Angiotensin Converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension", Am. J. Respir. Crit. Care Med. 2009, 179, 1048–1054. DOI
Butler, R. S.; Cohn, P.; Tenzel, P.; Abboud, K. A.; Castellano, R. K. "Synthesis, Photophysical Behavior, and Electronic Structure of Push–Pull Purines", J. Am. Chem. Soc. 2009, 131, 623–633. DOI
Yuan, L.; Sumpter, B. G.; Abboud, K. A.; Castellano, R. K. "Links Between Through-Bond Interactions and Assembly Structure in Simple Piperidones", New J. Chem. 2008, 32, 1924–1934 (published as a "hot article"). DOI
Castellano, R. K.; Lampkins, A. J.; Gubala, V.; Ostrov, D. A.; Raizada, M. K. "Structure-Based Identification of Small Molecule ACE2 Activators as Novel Antihypertensives", Hypertension 2008, 51, 1312–1317. DOI
Lampkins, A. J.; Li, Y.; Al Abbas, A.; Abboud, K. A.; Ghiviriga, I.; Castellano, R. K. "Assessable Consequences of Through-Bond Donor–Acceptor Interactions in β-Aminoketones", Chem. Eur. J. 2008, 14, 1452–1463.
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