Wanner, Klaus - Ludwig-Maximilians-Universität München

个人简介

Studied chemistry and pharmacy at TU and LMU Munich 1983 PhD, LMU Munich 1984-1985 Postdoctoral Researcher, Colorado State University/USA 1988 Habilitation 1990-1994 Assistant Professor for Pharmaceutical Chemistry, FU Berlin Since 1994 Full Pro

研究领域

GABA uptake inhibitors MS binding assays Asymmetric synthesis

近期论文

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T. Steffan, T. Renukappa-Gutke, G. Höfner, K.T. Wanner, "Design, synthesis and SAR studies of GABA uptake inhibitors derived from 2-substituted pyrrolidine-2-ylacetic acids", Bioorg. Med. Chem. 2015, 23, 1284-1306. (DOI) A. Jakubowska, J. Pabel, M. Żylewski, K. T. Wanner, K. Kulig, "Asymmetric synthesis of all four stereoisomers of 1-amino-3-hydroxycyclopentanecarboxylic acid", Tetrahedron 2015, 71, 686-693. (DOI) F. T. Kern, K.T. Wanner, "Generation and Screening of Oximes Libraries Addressing the Neuronal GABA Transporter GAT1", ChemMedChem. 2015, 10, 396-410. (DOI). S.Grimm, G.Höfner, K.T. Wanner, "Development and validation of an LC-ESI-MS/MS method for the triple reuptake inhibitor Indatraline enabling its quantification in MS Binding Assays", Anal. Bioanal Chem 2015, 407, 471-485. (DOI). S. Cuboni, C. Devigny, B. Hoogeland, A. Strasser, S. Pomplun, B. Hauger, G. Höfner, K.T. Wanner, M. Eder, A. Buschauer, F. Holsboer, F. Hausch, "Loratadine and analogs: Discovery and preliminary SAR of inhibitors of the amino acid transporter B0AT2", J. Med. Chem. 2014, 57, 9473-9479 (DOI). L. Allmendinger, K.T. Wanner, Synthesis of [2H7] Indatraline, J. Labelled Compd. Radiopharm. 2014, 57, 721-724 (DOI). G. Quandt, G. Höfner, J. Pabel, J. Dine, M. Eder, K. T. Wanner, "First Photoswitchable Neurotransmitter Transporter Inhibitor: Light-induced Control of γ-Aminobutyric Acid Transporter 1 (GAT1) Activity in Mouse Brain", J.Med. Chem. 2014, 57, 6809–6821 (DOI) S. Schmitt, G. Höfner, K.T. Wanner, MS Transport Assays for γ-aminobutyric acid transporters – an efficient alternative for radiometric assays, Anal. Chem. 2014, 86, 7575-7583. (DOI) P. Kowalczyk, K. Sałat, G. C. Höfner, M. Mucha, A. Rapacz, A. Podkowa, B. Filipek, K. T. Wanner, K. Kulig, "Synthesis, biological evaluation and structureeactivity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides", Eur. J. Med. Chem. 2014, 83, 256-273. (DOI) C. Wängler, S. Chowdhury, G. Höfner, P. Djurova, E.O. Purisima, P. Bartenstein, B. Wängler, G. Fricker, K.T. Wanner, R. Schirrmacher, Shuttle−Cargo Fusion Molecules of Transport Peptides and the hD2/3 Receptor Antagonist Fallypride: A Feasible Approach To Preserve Ligand−Receptor Binding?. J. Med. Chem. 2014, 57, 4368-4381. (DOI) T. Hellenbrand, K.T. Wanner, "Conjugate Addition of Organomagnesium Cuprates to Guvacine Derivatives", Eur. J. Org. Chem, 2014, 20, 4398-4409 (DOI) C. Schmaunz, P. Mayer, K.T. Wanner, "Inter- and Intramolecular [4+2] Cycloaddition Reactions with 4,4-Disubstituted N-Silyl-1,4-Dihydropyridines as Precursors for N-Protonated 2-Azabutadiene Intermediates", Synthesis 2014, 46, 1630-1638. (DOI) P. Kowalczyk, K. Sałat, G. C. Höfner, N. Guzior, B. Filipek, K. T. Wanner, K. Kulig, "2-Substituted 4-hydroxybutanamides as potential inhibitors of gamma-aminobutyric acid transporters mGAT1–mGAT4: Synthesis and biological evaluation, Bioorg. Med. Chem. 2013, 21, 5154-5167. (DOI) S. Schiesser, T. Pfaffeneder, K. Sadeghian, B. Hackner, B. Steigenberger, A.S. Schröder, J. Steinbacher, G. Kashiwazaki, G. Höfner, K.T. Wanner, C. Ochsenfeld, T. Carell, "Deamination, Oxidation and C-C bond Cleavage Reactivity of 5-Hydroxymethylcytosine, 5-Formylcytosine and 5-Carboxycytosine", J. Am. Chem. Soc. 2013, 135, 14593-14599. (DOI) S. H. Grimm, L. Allmendinger, G. Höfner, K.T. Wanner,"Enantiopurity Determination of the Enantiomers of the Triple Reuptake Inhibitor Indatraline", Chirality, 2013, 25, 923-933. (DOI) I. Sitka, L. Allmendinger, G. Fülep, G. Höfner, K.T. Wanner, "Synthesis of N-substituted acyclic β-amino acids and their investigation as GABA uptake inhibitors", Eur. J. Med. Chem., 2013, 65, 487-499. (DOI) S. Petz, K. T. Wanner, "Synthesis of 3-Azabicyclo[3.2.0]heptane Derivatives as gamma-Aminobutyric Acid Analogues via Intermolecular [2+2] Photocycloaddition", Eur. J. Org. Chem, 2013, 19, 4017-4025. (DOI) Cover Article G. Quandt, G. Höfner, K. T. Wanner, "Synthesis and evaluation of N-substituted nipecotic acid derivatives with an unsymmetrical bis-aromatic residue attached to a vinyl ether spacer as potential GABA uptake inhibitors, Bioorg. Med. Chem. 2013, 21, 3363-3378. (DOI) M. Sindelar, T. A. Lutz, M. Petrera, K.T. Wanner, "Focused Pseudostatic Hydrazone Libraries Screened by Mass Spectrometry Binding Assay – Optimizing Affinities towards γ-Aminobutyric Acid Transporter 1", J. Med. Chem., 2013, 56, 1323-1340. (DOI) X. Zhao, J. Pabel, G. Höfner, K.T. Wanner, "Synthesis and biological evaluation of 4- hydroxy-4-(4-methoxyphenyl)-substituted proline and pyrrolidin-2-ylacetic acid derivatives as GABA uptake inhibitors", Bioorg. Med. Chem., 2013, 2, 470–484. (DOI)