个人简介

何宏轩，博士，男，汉族，现为中国科学院动物研究所研究员，博士生导师，动物疫病研究组组长。《MolecularandBiochemistry》，《生物物理和生物化学》，《微生物学报》等杂志审稿人。中国动物学会和中国畜牧兽医学会会员。 1993年7月毕业于河南职业技术师范学院，获学士学位，1998年6月毕业于解放军农牧大学，获硕士学位，2002年6月毕业于解放军军需大学，获博士学位，2003年在清华大学生物科学与技术系作博士后研究，2004年在美国康乃尔大学作博士后研究。曾经获得河南省优秀中青年骨干教师，河南省教育系统学术技术带头人，河南省杰出青年等荣誉。曾在河南科技学院工作，自1996年起先后担任教研室主任、系副主任、系主任、副院长等职务。1999年7月任讲师，2002年6月任副教授，2005年8月任教授。2004年被河北师范大学和河南农业大学聘为硕士生导师，2006年被中国科学院动物研究所聘为博士生导师。 曾主持或参加“十一五”国家科技支撑重点项目、国家重点基础研究发展计划（973计划）、国家高技术研究发展计划（863）、国家自然科学基金、中国博士后基金以及河南省杰出青年基金等20余项。获得省部级科研奖7项。在《Emerginginfectiousdiseases》、《Journalofinfectiousdiseases》、《Reviewsinmedicalvirology》、《Vaccine》、《DNAandCellBiology》、《JournalofNanoscienceandNanotechnology》、《生物化学和生物物理进展》等国内外期刊发表学术论文120余篇。编写著作9部。。 工作经历 2006年1月－至今中国科学院动物研究所，研究员，博士生导师 2005年8月－2005年12月河南科技学院动物科学学院，教授 2004年10月－2005年11月美国康乃尔大学兽医学院，博士后 2003年1月－2004年10月清华大学生物科学与技术系，博士后 2002年6月－2005年8月河南科技学院动物科学系，副教授 1999年7月－2002年6月河南科技学院动物科学系，讲师 1993年7月－1999年7月河南职业技术师范学院畜牧兽医系，助教 学历 1999年9月－2002年6月中国人民解放军军需大学畜牧兽医学院，获农学博士学位 1996年9月－1998年6月中国人民解放军农牧大学畜牧兽医学院，获农学硕士学位 1989年9月－1993年6月河南科技学院畜牧兽医系，获农学学士学承担科研项目情况： 国家科技支撑计划课题，2009BAI83B00，项目名称：人兽共患病感染动物模型技术研究及我国特有野生动物实验动物化，2009BAI83B01，课题名称：重要人兽共患病野生动物野生和室内种群实验室感染模型的建立及差异性研究，2010-2012. 国家高技术研究发展计划（863）（2007AA100606）：重大动物疫病快速检测试剂的研发2007-2010。 国家重点基础研究发展计划（973计划）：农业鼠害暴发成灾规律、预测及可持续控制的基础研究（9732007BC109103），2007-2012。 科技部十二五支撑,野生动物跨境传播重要疫病监测与防控技术研究（“十二五”国家科技支撑计划2013BAD12B04），2013-2017。 国家自然科学基金，TRX-2抗氧化系统在缺硒状态宿主中抗微小隐孢子虫感染的作用机制研究（31072126），2011-2013。 国家自然科学基金，MicroRNA参与调控微小隐孢子虫感染缺硒宿主的分子机制研究（31101806），2012-2014. 国家林业局野生动物疫源疫病监测项目，候鸟禽霍乱疫源地追溯及其预警体系的建立，2014-2015。 现代农业产业技术体系北京市家禽创新团队，疫病控制岗位专家，2010-2015。

研究领域

研究领域： 研究兴趣主要集中在了解主要疾病疫源地生态和主要宿主迁徙动态、生境利用及其与家畜和人类活动关系的基础上，开展病原的检测和溯源研究，以及病原与宿主的协同进化关系；从人兽共患病病原体和宿主的关系入手，根据生物信息学原理和协同进化理论，运用病原学和分子生物学方法，调查野生动物病原多样性，揭示自然条件下野生动物源性疫病发生发展规律以及未知病原体/重大疫病对野生动物/家养动物/人类的内在影响机制。

研究兴趣主要集中在了解主要疾病疫源地生态和主要宿主迁徙动态、生境利用及其与家畜和人类活动关系的基础上，开展病原的检测和溯源研究，以及病原与宿主的协同进化关系；从人兽共患病病原体和宿主的关系入手，根据生物信息学原理和协同进化理论，运用病原学和分子生物学方法，调查野生动物病原多样性，揭示自然条件下野生动物源性疫病发生发展规律以及未知病原体/重大疫病对野生动物/家养动物/人类的内在影响机制。

近期论文

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ShelanLiu,ChengliangChai,ChengminWang,SaidAmer,HuakunLv,HongxuanHe,JiminSunandJunfenLin.Systematicreviewofseverefeverwiththrombocytopeniasyndrome:virology,epidemiology,andclinicalcharacteristics.ReviewsInMedicalVirology2014,24:90-102. GuoYunhai,HongxuanHe.Identificationandcharacterizationofagoose-typelysozymefromsewagesnailPhysaacuta.Fish&ShellfishImmunology,2014,39(2):321-325. LiuHuimin,YanJing,WangYutian,YanQi,ZhaoLinping,YanRuoqian,HongxuanHe.IsolationofMoraxellabovoculifromracehorseswithkeratoconjunctivitis.JournalOfVeterinaryDiagnosticInvestigation,2014,26(4):585-587. LiuHuimin,YanJing,LuoJing,YanRuoqian,ChenHao,ChengHai,LiuDawei,HongxuanHe.MycobacteriosisAssociatedwithMycobacteriumperegrinumInfectioninRed-CrownedCranes(Grusjaponensis)inChina.journalofwildlifediseases,2014,50(3):703-706. GaoShanshan,ZhangMin,AmerSaid,LuoJing,WangChengmin,WuShaoqiang,ZhaoBaohua,HongxuanHe.Developmentofanimmunomagneticbeadseparation-coupledquantitativePCRmethodforrapidandsensitivedetectionofCryptosporidiumparvumoocystsincalffeces.ParasitologyResearch,2014,13(6):2069-2077. LiuHuimin,WangYutian,YanJing,WangChengmin,HongxuanHe.AppearanceofMultidrug-ResistantVirulentRhodococcusequiClinicalIsolatesObtainedinChina.JournalOfClinicalMicrobiology,2014,52(2):703-703 TaoZhangandHongxuanHe.Testofimmunocompetencehandicaphypothesisinmice(Musmusculus)infectedwithTrichinellaspiralis.CanadianJournalofZoology,2014,92:817–821 JoyScaria,Jenn-WeiChen,NicodemusUseh,HongxuanHe,SeanP.McDonough,ChunhongMao,BrunoSobral,Yung-FuChang.ComparativenutritionalandchemicalphenomeofClostridiumdifficileisolatesdeterminedusingphenotypemicroarrays.InternationalJournalofInfectiousDiseases,27(2014)e20–e25 GuoyingDong,JingLuo,KaiZhou,BinWu,ChaoPeng,GuangjuJi,HongxuanHe.Characterizationoftheamantadine-resistantH5N1highlypathogenicavianinfluenzavariantsisolatedfromquailsinSouthernChina.VirusGenes,2014.49(2)223-232. ChengminWang,JingLuo,JingWang,WenSu,ShanshanGao,MinZhang,LiXie,HuaDing,ShelanLiu,XiaodongLiu,YuChen,YaxiongJia,HongxuanHe.NovelhumanH7N9InfluenzaVirusinChina.IntegrativeZoology,2014,9:356–361. ChengminWang,JingWang,WenSu,ShanshanGao,JingLuo,MinZhang,LiXie,ShelanLiu,XiaodongLiu,YuChen,YaxiongJia,HongZhang,HuaDing,HongxuanHe.RelationshipbetweendomesticandwildbirdsinlivepoultrymarketandanovelhumanH7N9virusinChina.TheJournalofInfectiousdiseases,2014,209(1):34-37. YingchunDu,JingLuo,ChengminWang,QingnaWen,MingxingDuan,HongZhang,andHongxuanHe.DetectionofDrug-ResistantKlebsiellapneumoniaeinChinesehares(Lepussinensis).JournalofWildlifeDisease,2014,50(1):109-12 JingLuo,GuoyingDong,KaiLi,ZongjiLv,XiaoweiHuo,andHongxuanHe.ExposuretoswineH1andH3andavianH5andH9influenzaAvirusesamongferalswineinsouthernChina,2009.JournalofWildlifeDiseases,2013,49(2):375-380. Jun-SongWu,NaZhao,HaoPan,Cheng-MinWang,BinWu,Hong-MeiZhang,HongxuanHe,DanLiu,SaidAmer,She-LanLiu.PatternsofpolymorphismanddivergenceintheVP1geneofenterovirus71circulatingintheAsia-Pacificregionbetween1994and2013.JournalofVirologicalMethods,2013,193:713–728. She-LanLiu,JingWang,Xu-HuiYang,JinChen,Ren-JieHuang,BingRuan,HongxuanHe,ChengminWang,Hong-MeiZhang,ZhouSun,LiXieandHuiZhuang.PandemicinfluenzaA(H1N1)2009virusinpregnancy.ReviewsinMedicalVirology,2013,23:3–14. ChengminWang，HongxuanHe.Leptospiraspp.inCommensalRodents,Beijing,China.JournalofWildlifeDiseases,2013,49(2):461-463. ChengminWang,YanyuZhang,BinWu,ShelanLiu,PingXu,YanminLu,JingLuo,DaleLouisNolte,ThomasJudeDeliberto,MingxingDuan,HongZhang,HongxuanHe.EvolutionarycharacterizationofthepandemicH1N1/2009InfluenzaVirusinhumansbasedonnon-structuralgenes.PLoSONE,2013,8(2):e56201. ShanshanGao,NaZhaoa,SaidAmer,MingmingQian,MengxiLv,YuliangZhao,XinSu,JieyingCao,HongxuanHe,BaohuaZhao.ProtectiveefficacyofPLGAmicrospheresloadedwithdivalentDNAvaccineencodingtheompAgeneofAeromonasveroniiandthehlygeneofAeromonashydrophilainmice,Vaccine,2013,48(19):5754-5759. LiuH,YanQ,ZhaoB,LuoJ,WangC,DuY,YanJ,HongxuanHe.Isolation,molecularcharacterization,andphylogeneticanalysisofencephalomyocarditisvirusfromSouthChinatigersinChina.Infection,GeneticsandEvolution,2013,19:240–243. LiuH,YanQ,HongxuanHe.CompleteNucleotideSequenceofEncephalomyocarditisVirusIsolatedfromSouthChinaTigersinChina.GenomeA,1(4):e00651-13. ZhangMinandHongxuanHe.Parasite-mediatedselectionofmajorhistocompatibilitycomplexvariabilityinwildbrandt’svoles(Lasiopodomysbrandtii)fromInnerMongolia,China.BMCEvolutionaryBiology,2013,13:149. HuYi,LIUPeng-Peng,ZHANGZhi-Ming,LUHe-Zhen,LUOJing,WANGCheng-Min,LIUJun-Xu,ZHAOBao-Hua,HongxuanHe.InhibitionofHighlyPathogenicAvianInfluenzaAVirusH5N1GrowthandInductionofInflammatoryMediatorsbyGeldanamycinProgressinBiochemistryandBiophysics,2013,40(11):1132~1139 ChengminWang,JingWang,JingLuo,LiXie,HuaDing,ShelanLiu,XiaodongLiu,YuChen,YaxiongJia,HongxuanHe.RelationshipbetweenH7subtypeavianinfluenzavirusandpoultryandhuman.ProgressinBiochemistryandBiophysics,2013,40(5):416~424. WenjieDong,JingLuo,HongxuanHe,LongJiang.AreinforcedcompositestructurecomposedofpolydiacetyleneassembliesdepositedonpolystyrenemicrospheresanditsapplicationtoH5N1virusdetection.InternationalJournalofNanomedicine,2013:8:221-232 ShelanLiu,ChengliangChai,ChengminWang,SaidAmer,HuakunLv,HongxuanHe,JiminSunandJunfenLin.Systematicreviewofseverefeverwiththrombocytopeniasyndrome:virology,epidemiology,andclinicalcharacteristics.ReviewsinMedicalVirology,2013,DOI:10.1002/rmv.1776 ShelanLiu,JingWang,XuluiYang,JinChen,RenjieHuang,BingRuan,HongxuanHe,ChengminWang,HongmeiZhang,ZhouSun,LiXie,HuiZhuang.PandemicinfluenzaA(H1N1)2009virusinpregnancy.ReviewsinMedicalvirology,2013,23:3–14. JingLuo,ZhigaoZeng,YanlingSong,HongxuanHe.BrucellosisinTakins,China.EmergingInfectiousDiseases,2012,18(9):1527-1529. SarahN.Bevins,JohnA.Baroch,DaleL.Nolte,MinZhang,HongxuanHe.Yersiniapestis:examiningwildlifeplaguesurveillanceinChinaandtheUSA.IntegrativeZoology,2012,7(1):99-109. DidiChen,PeiGuo,ShaChen,YuCao,WanzhenJi,XiaLei,LinaLiu,Peiguangzhao,RuihongWang,Chaoqi,YanliLiu,HongxuanHe.Propertiesofxyloglucanhydrogelasthebiomedicalsustained-releasecarriers.JournalofMaterialsScience:MaterialsinMedicine,2012,23(4):955-962. QiumeiShi,YanyingZhang,QiuyueWang,GuishengGao,HaiFang,FuchunMiao,ZengqiangYuanandHongxuanHe.PhylogeneticanalysisofvirulencefactorgeneofSalmonellaisolatedfromclinicallysymptomaticChickens.AfricanJournalofMicrobiologyResearch,2012,6(8),1718-1722. HuaFu,LiguoLiu,XiaobingZhang,YafangZhu,LinaZhao,JunpingPeng,HongxuanHe,QiJin.CommonChangesinGlobalGeneExpressionInducedbyRNAPolymeraseInhibitorsinshigellaflexneri.PLOSOne,2012,7(3):e33240 QiumeiShi,GuishengGao,YanyingZhang,Huaxiang,ZengqiangYuan,HongxuanHe.CloningofstructuralproteinVP1geneoffootandmouthDiseasevirusanditsexpressioninEscherichiacoli.JournalofAnimalandVeterinaryAdvances,2012,11(3):426-430. HanweiJiao,LiDu,YongchangHao,YingCheng,JingLuo,wenhuaKuang,DonglinZhang,MingLei,XiaoxiaoJia,XiaoruZhang,ChaoQi,HongxuanHe,FengyangWang.EffectiveinhibitionofmRNAaccumulationandproteinexpressionofH5N1avianinfluenzavirusNS1geneinvitrobysmallinterferingRNAs.FoliaMicrobiol,2012,DOI10.1007/s12223-012-0212-8. WangBaoLin,LiuBo,ChenLing,ZhangJianYong,HongxuanHe,ZhangHong.Qualitativeandquantitativeanalysesofinfluenzavirusreceptorsintracheaandlungtissuesofhumans,mice,chickensandducks.SciChinaLifeSci,2012,55:612–617. WeiLei,QinglongLiang,LuoJing,ChengminWang,XiaobingWu,HongxuanHe.BoLA-DRB3genepolymorphismandFMDresistanceorsusceptibilityinWanbeicattle.MolBiolRep,2012,39:9203–9209. ChengminWang,JingLuo,SaidAmer,YunhaiGuo,YiHu,YanminLu,HaijingWang,MingxingDuan,HongxuanHe.MultivalentDNAvaccineinducesprotectiveimmuneresponsesandenhancedresistanceagainstCryptosporidiumparvuminfection.Vaccine2011,29,323–328. KaiLi,JingLuo,ChengminWang,HongxuanHe.a-GalactosylceramidepotentlyaugmentsM2e-inducedprotectiveimmunityagainsthighlypathogenicH5N1avianinfluenzavirusinfectioninmice.Vaccine,2011,29:7711–7717 Qing-longLiang,JingLuo,KaiZhou,Jian-xinDong,HongxuanHe.Immune-relatedgeneexpressioninresponsetoH5N1avianinfluenzavirusinfectioninchickenandduckembryonicfibroblasts.MolecularImmunology,2011,48:924–930. GuoyingDong,JingLuo,HongZhang,ChengminWang,MingxingDuan,ThomasJudeDeliberto,DaleLouisNolte,GuangjuJi,HongxuanHe.PhylogeneticDiversityandGenotypicalComplexityofH9N2InfluenzaAVirusesRevealedbyGenomicSequenceAnalysis.PLoSONE,2011,6(2):e17212. GuoyingDong,CongXu,ChengminWang,BinWu,JingLuo,HongZhang,DaleLouisNolte,ThomasJudeDeliberto,MingxingDuan,GuangjuJi,HongxuanHe.ReassortantH9N2InfluenzaVirusesContainingH5N1-LikePB1GenesIsolatedfromBlack-BilledMagpiesinSouthernChina.PLoSONE,2011,6(9):e25808. LiuSL,ZhangZ,WangC,DongY,PanH,SunZ,YangXH,WangJ,RuanB,XieL,DengJ,HongxuanHe.EvolutionaryCharacterizationofHumanH1N1InfluenzaVirusHemagglutininGenesIsolatedfrom1947to2009inChina.Intervirology,2011,DOI:10.1159/000322383. YuelanZhao,ChengminWang,YanminLu,SaidAmer,PingXu,JianyongWang,JunxiaLu,YongzhanBao,BolinDeng,HongxuanHe,JianhuaQin.ProkaryoticExpressionandIdentificationof3-1EGeneofmerozoitesurfaceantigenofEimeriaacervulina.ParasitologyResearch,2011,109:1361–1365. QiumeiShi,GuishengGao,YanyingZhang,HuaXiang,ZengqiangYuan,HongxuanHe.CloningofstructuralproteinVP1geneoffootandmouthvirusanditsexpressioninEscherichiacoli.JournalofAmimalandVeterinaryAdvances,2011,11(3):426-430 Yucao,didichen,peiguangzhao,linaliu,xueyinghuang,chaoqi,yanliliu,HongxuanHe,qianwang,yangliu,andshachen.IntracellularDeliveryofMitomycinCwithTargetedPolysaccharideConjugatesAgainstMultidrugResistance.AnnalsofBiomedicalEngineering,2011,DOI:10.1007/s10439-011-0333-2. LeiWei,XinweiWang,ChengminWangandHongxuanHe.AsurveyofectoparasitesfromwildrodentsandAnourosorexsquamipesinSichuanProvince,SouthwestChina.JournalofEcologyandtheNaturalEnvironment,2010,2(8),160-166. SaidAmer,ChengminWangandHongxuanHe.FirstDetectionofCryptosporidiumbaileyiinRuddyShelduck(Tadornaferruginea)inChina.J.Vet.Med.Sci.2010,72(7):935–938. ChengminWang,BinWu,SaidAmer,JingLuo,HongmeiZhang,YunhaiGuo,GuoyingDong,BaohuaZhao,HongxuanHe.PhylogeneticanalysisandmolecularcharacteristicsofsevenvariantChinesefieldisolatesofPRRSV.BMCMicrobiol,2010.doi:10.1186/1471-2180-10-146. BinWu,ChengminWang,GuoyingDong,YunhaiGuo,DaleLouisNolte,ThomasJudeDeliberto,JianguoXu,MingxingDuan,HongxuanHe.NewEvidencesRevealSouthernChinaIsacommonSourceofMultipleH5N1Clusters.TheJournalofInfectiousDiseases,2010,202(3):452–458. QinglongLiang,LeiWei,XinweiWang,HongxuanHe.MHCClassILocifromtheBar-HeadedGoose(Anserindicus).GeneticsandMolecularBiology,2010,33(3):573-577 YuelanZhao,SaidAmer,JianyongWang,ChengminWang,YingGao,GuiyingKang,YongzhanBao,HongxuanHe,JianhuaQin.Construction,screeningandidentificationofaphagedisplayantibodylibraryagainsttheEimeriaacervulinamerozoite.BiochemicalandBiophysicalResearchCommunications,2010,393:703–707. YuCao,YingGu,HongMa,JingBai,LinaLiu,PeiguangZhao,HongxuanHe.Self-assemblednanoparticledrugdeliverysystemsfromgalactosylatedpolysaccharide–doxorubicinconjugateloadeddoxorubicin.InternationalJournalofBiologicalMacromolecules,2010,46,245–249. QinglongLiang,KaiZhou,HongxuanHe.Retrocyclin2:anewtherapyagainstH5N1virusinvivoandvitro.BiotechnologyLetters,2010,32:387–392. TangYi,CHUGuang-yue,HongxuanHe,YUCui-ping,ANJian-xiong,GUOXiang-yang.Screeningofdifferentiallyexpressedgenesinthehypothalamusofaratneuropathicpainmodelfollowingsciaticnerveinjury.ChineseMedicalJournal,2009,122(23):2893-2897. SheLanLiu,Zhi-RuoZhang,ChengminWang,YingDong,Lun-BiaoCui,Xu-HuiYang,ZhouSun,JingWang,JinChen,Ren-JieHuang,FanMiao,BingRuan,LiXie,HongxuanHe,JingDeng.2009pandemiccharacteristicsandcontrollingexperiencesofinfluenzaH1N1virus1yearaftertheinceptioninHangzhou,China.Journalofmedicalvirology,2010，82:1985–1995. WuB,WangCM,DongGY,HongxuanHe.MolecularcharacterizationofH1N1influenzaAvirusesfromhumancasesinNorthAmerica.ChineseSciBull,2009,54(13):2179-2192. ChengminWANG,HongxuanHE,MingLI,FuminLEI,J.JeffreyRoot,YanyunWU,JianhuaQIN.Parasitespeciesassociatedwithwildplateaupika(Ochotonacurzoniae)insouth-easternQinghaiProvince,China.Journalofwildlifedisease,2009,45(2):288-294. ChengminWang,YanyunWu,JianhuaQin,HaoxueSun,andHongxuanHe.InducedsusceptibilityofhostisassociatedwithanimpairedantioxidantsystemfollowinginfectionwithCryptosporidiumparvuminSe-deficientmice.PLoSONE4(2):e4628. ChengminWang,HongxuanHe,MingxingDuanDevelopmentandevaluationofarecombinantCP23antigen-basedELISAforserodiagnosisofCryptosporidiumparvum.ExperimentalParasitology,2009,121(2):157-162 ZhouKai,HongxuanHe.AvianInfluenzaandSwineInfluenza:NewUnderstandingofCrossingSpeciesBarrier.ProgressinBiochemistryandBiophysics,2009,36(5):523~529 Wangxinwei,HongxuanHe,ZelinWang,YanyunWu,ChengminWang.Detectiononantigenofinfectiousbronchitisvirusinchickenbysilver-enhancedcolloidalgoldassay.ChinJVetSci,2009,29(4):204-399 LiqiangFeng,FengLi,XuehuaZheng,WeiqiPan,KaiZhou,YichuLiu,HongxuanHe,LingChen.ThemousePolIterminatorismoreefficientthanthehepatitisdeltavirusribozymeingeneratinginfluenzavirus-likeRNAswithprecise3'endsinaplasmid-only-basedvirusrescuesystem.ArchivesofVirology,2009,DOI10.1007/s00705-009-0422-9

学术兼职

国家林业局中国科学院野生动物疫病研究中心常务副主任 国家林业局野生动物疫病预警与防控专家组成员 亚太野生动物疫病合作网络中方负责人 国际野生动物疫病协会理事 亚洲生物技术协会联合会委员 国际动物学会会员 《中国媒介生物学及控制杂志》编委 《IntegrativeZoology（整合动物学）》编委 《JournalofMolecularEpidemiologyandEvolutionaryGeneticsofInfectiousDiseases》特约审稿人 《AmericanJournalofTropicalMedicine&Hygiene》特约审稿人 《JournalofHelminthology》特约审稿人 《PloSone》特约审稿人