Cosstick, Rick - University of Liverpool

研究领域

DNA (deoxyribonucleic acid) is the permanent repository of genetic information and the acquired understanding of the structure and function of DNA and the related RNA (ribonucleic acid), represent one of the greatest ever triumphs for chemistry and biology. It is not surprising that most of the licensed antiviral drugs (e.g. Zovirax and AZT) and many anticancer drugs are nucleoside analogues which are able to interfere with nucleic acid biosynthesis in a selective manner. Additionally, much of the recent information on the structure/function relationship of nucleic acids has come from using DNA/RNA probes that contain a subtle chemical modification. Present work within the group is concerned with studies on the synthesis of novel nucleic acids analogues as both potential therapeutic agents and as probes for understanding the precise mechanism by which nucleic acids fulfill their biological functions.

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Tautomerism in 8-Nitroguanosine Studied by NMR and Theoretical Calculations Nicked-site substrates for a serine recombinase reveal enzyme-DNA communications and an essential tethering role of covalent enzyme-DNA linkages Probing the Run-On Oligomer of Activated SgrAI Bound to DNA Stabilization of a Bimolecular Triplex by 3 '-S-Phosphorothiolate Modifications: An NMR and UV Thermal Melting Investigation Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation Thermal stabilisation of RNA·RNA duplexes and G-quadruplexes by phosphorothiolate linkages Base-pairing preferences, physicochemical properties and mutational behaviour of the DNA lesion 8-nitroguanine Dinucleotides containing 3'-S-phosphorothiolate linkages A novel mechanism for the scission of double-stranded DNA: BfiI cuts both 3'-5' and 5'-3' strands by rotating a single active site RNA interference: a chemist's perspective Reverse-direction (5'-->3') synthesis of oligonucleotides containing a 3'-S-phosphorothiolate linkage and 3'-terminal 3'-thionucleosides Antitumour and antimalarial activity of artemisinin-acridine hybrids Nitrobenzyl Phototrigger for Fast Protein Folding Processes Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells Foldamers derived from nucleoside beta-amino acids: a new twist on the DNA helix Incorporation of 3'-S-phosphorothiolates into RNA: potential applications in RNAi Peptides derived from nucleoside beta-amino acids form an unusual 8-helix Synthesis, Properties and Application of Nucleic Acids Containing Phosphorothiolate Linkages The effect of 2'-fluorine substitutions on DNA i-motif conformation and stability Towards fluorous-phase synthesis of nucleoside beta-peptides Duplex stability of DNA.DNA and DNA.RNA duplexes containing 3'-S-phosphorothiolate linkages Enzymatic disassembly of DNA-gold nanostructures Foldamers derived from nucleoside beta-amino acids: PNA Or DNA? Can we have both in one place? Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity Incorporation of a S-glycosidic linkage into a glyconucleoside changes the conformational preference of both furanose sugars