Yates, Ed - University of Liverpool - Department of Biochemistry

个人简介

1. Education and Employment. University of Leeds, Astbury Department of Biophysics BSc(hons) 1989 Biophysics University of Leeds, Department of Biochemistry and Molecular Biology PhD (1993) 'Synthetic and Structural Studies of Sulphated Carbohydrates' supervised by Drs W Mackie and B Sheldrick Post-doc, University of Leeds, Centre for Plant Biochemistry and Biotechnology (1993-1994) Dr J Paul Knox Post-doc EU Carbohydrate Research Network, Ronzoni Institute for Chemical and Biochemical Research, Milan, Italy (1995-1998) Prof Benito Casu Post-doc, University of Birmingham, Department of Chemistry, (1998-1999) Prof Geert-Jan Boons Post-doc, University of Birmingham, School of Biosciences, (1999-2003) Dr Jerry Turnbull Principal Experimental Officer, School of Biological Sciences, University of Liverpool (2003-2008) Lecturer, Department of Biochemistry, Institute of Integrative Biology, University of Liverpool (2008-present) University of Liverpool, Department of Continuing Education, PG Cert (T & L in HE) (2011) Associate Professor, Department of Biochemistry, Federal University of Sao Paulo (UNIFESP), SP, Brazil 2. Research Collaborations I collaborate with colleagues from a wide-range of backgrounds and areas ranging from Microbiology, through Chemistry, to Physics. In particular, I continue to work closely with Tim Rudd (formerly UoL, Diamond Synchrotron and now the National Institute of Biological Standards and Controls (NIBSC) and Marco Guerrini (Ronzoni Institute, Milan) on aspects of the structure, activity and safety of the pharmaceutical agent, heparin, and its derivatives. I have also developed close links with Helena Nader, Marcelo Lima and colleagues at UNIFESP (Brazil). 3. My group has hosted a number of PhD students and post-docs, several of whom have gone on to pursue independent academic or industrial careers. Topics of study have been varied, covering structural investigations employing spectroscopic techniques to the application of carbohydrates as agents of disrupting disease processes in Malaria. British Society of Parasitology Annual Meeting (Invitation to Speak, Organising Committee 2011) Invited lectures (Invitation to Speak, Department of Biochemistry, Federal University of Sao Paolo (UNIFESP) 2011) 40th Anniversary Meeting of the Brazilian Biochemistry and Molecular Biology Society (Invitation to Speak, sBBQ 2011) conference talk (Invitation to Speak, organising committee 2011) invited talk (Invitation to Speak, organising committee 2010) invited talk (Invitation to Speak, organising committee 2010) Conference Speaker (Invitation to Speak, Organising Committe 2009) Conference Speaker (Invitation to Speak, Organising Committee 2008) Invitation to speak (Invitation to Speak, Italian-german organising committee 2007) Invitation to speak (Invitation to Speak, Slovak Academy of Sciences 2007) Invitation to speak (Invitation to Speak, Slovak Academy of Sciences 2007) Invitation to speak (Invitation to Speak, Italian-german organising committee 2006) Invitation to speak (Invitation to Speak, RSC 2006) Invitation to speak (Invitation to Speak, Italian-german organising committee 2005) Feingold award (Anaerobe Society of the Americas 2005) Invitation to speak (Invitation to Speak, Italian-german organising committee 2004) Invitation to speak (Invitation to Speak, RSC 2003) Supervision of PDRA primary PhD supervision joint PhD student supervision MRes supervision exam setting/marking

研究领域

Glycosaminoglycan structure function relationships. Protein-sugar interactions and spectroscopic methods for their study. Carbohydrate chemistry. Microbial-sugar interactions and their inhibition.

近期论文

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Coupling of vinculin to F-actin demands Syndecan-4 proteoglycan. Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells. (19)F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy. Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-beta Fibrils. Heparan sulfate and heparin interactions with proteins. Journal of the Royal Society Interface. Heparin binding preference and structures in the fibroblast growth factor family parallel their evolutionary diversification. Johann Peter Griess FRS (1829–88): Victorian brewer and synthetic dye chemist. Nuclear Magnetic Resonance and Molecular Dynamics Simulation of the Interaction between Recognition Protein H7 of the Novel Influenza Virus H7N9 and Glycan Cell Surface Receptors. Panels of chemically-modified heparin polysaccharides and natural heparan sulfate saccharides both exhibit differences in binding to Slit and Robo, as well as variation between protein binding and cellular activity. Recent innovations in the structural analysis of heparin. Recent innovations in the structural analysis of heparin. Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis. Detection of interaction between protein trytophan residues and small or macromolecular ligands by synchrotron radiation magnetic circular dichroism. Differentiation of Generic Enoxaparins Marketed in the United States by Employing NMR and Multivariate Analysis. Enhanced Tumorigenic Potential of Colorectal Cancer Cells by Extracellular Sulfatases. Heparan sulfate and heparin interactions with proteins. Heparan sulfate and heparin: Structure and function. Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding. Heparin derivatives for the targeting of multiple activities in the inflammatory response.