Wilkinson, Mark - University of Liverpool - Department of Biochemistry

研究领域

Microscale protein isolation and analysis; developing sophisticated analytical services based on the current protein sequencing service; characterisation of recombinant vaccine to hepatitis B; analysis of antigens of pathogenic bacteria including those implicated in stomach ulcer formation; 2D gel database of proteins from breast and colon tumours; enzymatic synthesis of chiral intermediates.

近期论文

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Heparin binding preference and structures in the fibroblast growth factor family parallel their evolutionary diversification. Snake Venom Metalloproteinases and Their Peptide Inhibitors from Myanmar Russell's Viper Venom. Bacterial sensing underlies artificial sweetener-induced growth of gut Lactobacillus. Diadenosine 5 ', 5 '''-P-1,P-4-tetraphosphate (Ap(4)A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication. HaloTag is an effective expression and solubilisation fusion partner for a range of fibroblast growth factors. Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial Amyloid. Pharmacokinetics of Meropenem for Use in Bacterial Keratitis. Expression and purification of the aortic amyloid polypeptide medin. Glycosylated yellow laccases of the basidiomycete Stropharia aeruginosa. Purification, characterisation and expression in Saccharomyces cerevisiae of LipG7 an enantioselective, cold-adapted lipase from the Antarctic filamentous fungus Geomyces sp. P7 with unusual thermostability characteristics. A Systems Biology Approach for the Investigation of the Heparin/Heparan Sulfate Interactome. A systems biology approach for the investigation of the heparin/heparan sulfate interactome. Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships. Differential Scanning Fluorimetry Measurement of Protein Stability Changes upon Binding to Glycosaminoglycans: A Screening Test for Binding Specificity.