Mitchell, Phil - University of Sheffield - Department of Molecular Biology and Biotechnology

个人简介

Career History 2004 - present: Lecturer, University of Sheffield 1997 - 2004: PDRA (Tollervey lab), Wellcome Trust Centre for Cell Biology, University of Edinburgh 1993 - 1996: Research Fellow (Tollervey lab), EMBL, Heidelberg, Germany 1993: Visiting Scientist (Zimmerman lab), University of Amherst, USA 1991 - 1992: PDRA (Brimacombe lab), Max Planck Institute for Molecular Genetics, Berlin, Germany 1988 - 1990: PhD, King’s College, University of London

研究领域

Building on the discovery and characterisation of the exosome ribonuclease complex (Mitchell et al., 1997; Allmang et al., 1999), my lab’s research addresses the molecular mechanisms of RNA quality control in eukaryotic cells.

近期论文

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Mitchell P (2014) Exosome substrate targeting: the long and short of it. Biochemical Society Transactions, 42(4), 1129-1134. View this article in WRRO Feigenbutz M, Garland W, Turner M & Mitchell PJ (2013) The exosome cofactor Rrp47 is critical for the stability and normal expression of its associated exoribonuclease Rrp6 in Saccharomyces cerevisiae. PLOS One. View this article in WRRO Garland W, Feigenbutz M, Turner M & Mitchell P (2013) Rrp47 functions in RNA surveillance and stable RNA processing when divorced from the exoribonuclease and exosome-binding domains of Rrp6.. RNA, 19(12), 1659-1668. Feigenbutz M, Jones R, Besong TM, Harding SE & Mitchell P (2013) Assembly of the yeast exoribonuclease Rrp6 with its associated cofactor Rrp47 occurs in the nucleus and is critical for the controlled expression of Rrp47.. J Biol Chem, 288(22), 15959-15970. Costello JL, Stead JA, Feigenbutz M, Jones RM & Mitchell P (2011) The C-terminal region of the exosome-associated protein Rrp47 is specifically required for box C/D small nucleolar RNA 3'-maturation.. J Biol Chem, 286(6), 4535-4543. Mitchell P & Tollervey D (2011) Finding the exosome.. Adv Exp Med Biol, 702, 1-8. Mitchell P (2010) Rrp47 and the function of the Sas10/C1D domain.. Biochem Soc Trans, 38(4), 1088-1092. View this article in WRRO Mitchell P & Tollervey D (2010) Finding the exosome. Advances in Experimental Medicine and Biology, 702, 1-8. Butler JS & Mitchell P (2010) Rrp6, Rrp47 and Cofactors of the Nuclear Exosome. Advances in Experimental Medicine and Biology, 702, 91-104. Stead JA, Costello JL, Livingstone MJ & Mitchell P (2007) The PMC2NT domain of the catalytic exosome subunit Rrp6p provides the interface for binding with its cofactor Rrp47p, a nucleic acid-binding protein.. Nucleic Acids Res, 35(16), 5556-5567. View this article in WRRO Schuch B, Feigenbutz M, Makino DL, Falk S, Basquin C, Mitchell P & Conti E () The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase.. EMBO J.. View this article in WRRO