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个人简介

2004.09—2012.06 东北农业大学 生物科学 理学博士学位(本-硕-博连读) 2012.07 - 2014.06 中国科学院大连化学物理研究所,博士后 2014.07 - 2015.06 中国科学院大连化学物理研究所,助理研究员 2015.06 - 2017.03 中国科学院大连化学物理研究所,副研究员 2017.03 - 2022.12 上海中医药大学, 副研究员 2019.04 - 2020.05 美国国立卫生研究院(NIH), 高级访问学者 2023.01 - 至今 上海中医药大学, 研究员

研究领域

1)药物代谢酶可视化分析新方法与新技术研究 2)天然酶抑制剂/降解剂的高效发现及其成药性优化研究

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Fan, Y.F., Wu, Y., Hou, J., Wang, P.*, Peng, X.J., Ge, G.B.* Coumarin-based near-infrared fluorogenic probes: Recent advances, challenges and future perspectives. Coordination Chemistry Reviews, 2023, 480, 215020. ( IF: 24.833) Hou, F.B., Zhang, N., Zhu, G.H., Fan, Y.F., Sun, M.R., Nie, L.L., zheng Y.J.*, Wang, P.* Functional Imaging and Inhibitor Screening of Human Pancreatic Lipase by a Resorufin-Based Fluorescent Probe. Biosensors, 2023, 13(2), 283. ( IF: 5.743) Wang FY#, Wang P#, Zhao DF, Gonzalez FJ. Fan YF, Xia YL*, Ge GB*, Yang L*, Analytical methodologies for sensing Catechol-O-methyltransferase activity and their applications. Journal of Pharmaceutical Analysis, 2021,11(1), 15-27. ( IF: 14.026) Xia YL#, Wang P#, Yan N, Gonzalez FJ*, Yan T*. Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3. Cell death & disease, 2021, 12(2), 1-14.( IF:9.685) Hu Q#, Tian ZH#, Wang HN, Huang J, Wang FY, Zhao B, He RJ, Jin Q, Hou XD, Hou J, Fang SQ*, Wang P*, Ge, GB*. Rational design and development of a novel and highly specific near-infrared fluorogenic substrate for sensing and imaging of human pancreatic lipase in living systems. Sensors and Actuators B: Chemical, 2021, 341, 130033. ( IF:9.221) Fan, Y. F. #, Wang, F. Y. #, Hou, F. B., Wei, L., Zhu, G. H., Zhao, D. F., Hu, Q., Lei, T., Yang, L.*, Wang, P.*, Ge, G. B.*, A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples, Chinese Chemical Letters, 2022, 34(2), 107557. (IF: 8.455) Hamada K#, Wang P#, Xia Y#, Yan N, Takahashi S, Krausz KW, Hao H, Yan T, Gonzalez FJ. Withaferin A alleviates ethanol-induced liver injury by inhibiting hepatic lipogenesis. Food Chem Toxicol. 2022; 160:112807. (IF: 5.572) Yan TT#, Luo YH#, Xia YL, Hamada K, Wang Q, Yan NN,.Krausz KW, Ward JM, Hao HP, Wang P*, Gonzalez GJ*, St. John’s Wort alleviates dextran sodium sulfate-induced colitis through pregnane X receptor-dependent NFκB antagonism,FASEB Journal,2021,35:e21968. ( IF:5.834) Fan YF, Zhu SX, Hou FB, Zhao DF, Pan QS, Xiang YW, Qian XK, Ge GB, Wang P*,Spectrophotometric assays for sensing tyrosinase activity and their applications,Biosensors.2021, 8, 290( IF:5.743) Wang FY#, Wei GL#, Fan Y.F, Zhao DF, Wang P*, Zou LW, & Yang L*. Inhibition of catechol-O-methyltransferase by natural pentacyclic triterpenes: structure–activity relationships and kinetic mechanism. Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, 36(1), 1079-1087. ( IF:5.756) Zhao DF#, Fan YF#, Wang FY, Hou FB, Gonzalez FJ, Li SY, Wang P*, Xia YL*, Ge GB, Yang, L. Discovery and characterization of naturally occurring potent inhibitors of catechol-O-methyltransferase from herbal medicines. RSC Advances, 2021, 11(17), 10385-10392. ( IF: 4.036) Xia YL, Wang JJ, Li SY, Liu Y, Gonzalez FJ, Wang P*, Ge GB. Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment. Bioorganic & Medicinal Chemistry, 2021, 29, 115851. ( IF: 3.461) Zhao DF#, Fan YF#, Yu HN, Hou FB, Xiang YW, Wang P*, Ge GB*, Yang L, Xu JG. Discovery and characterization of flavonoids in vine tea as catechol-O-methyltransferase inhibitors. Fitoterapia, 2021, 104913. ( IF: 3.204) Xia YL, Pang HL, Li SY, Liu Y, Wang P*, Ge GB, Accurate and sensitive detection of Catechol-O-methyltransferase activity by liquid chromatography with fluorescence detection. Journal of Chromatography B, 2020, 1157, 122333. ( IF: 3.318) Liu XY#; Lv Xia#; Wang P #; Ai CZ; Zhou QH; Finel M; Fan B; Cao YF; Tang H*; Ge GB*, Inhibition of UGT1A1 by natural and synthetic flavonoids, International Journal of Biological Macromolecules, 2019, 126: 653~661 ( IF:8.025)

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