毛旭明 - 浙江大学

个人简介

2016.1-至今，浙江大学，教授 2011.1-2015.12，浙江大学，副教授 2013.5-2015.5，美国加州大学洛杉矶分校（University of California, Los Angeles. UCLA）访问学者 2009.5-2010.12，浙江大学，助理研究员 2007.5-2009.5，浙江大学，师资博士后 2006.9-2007.4，浙江大学，智力引进教师 2001.9-2006.8，中国科学院上海生命科学研究院，生物化学与细胞生物学研究所，博士 1997.9-2001.7，复旦大学，本科

研究领域

1、创新药研发 i) 微生物中新活性天然产物挖掘，生物合成机制解析及成药性评价 ii) 基于生物合成实现活性天然产物的结构修饰，提高成药性 2、仿制药改造 i) 利用生产菌重塑实现大品种微生物药物的高效合成 ii) 利用异源表达实现低产高附加值微生物药物的高效生物合成

近期论文

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Cao F#, Ma LF#, Hu LS, Xu CX, Chen X, Zhan ZJ, Zhao QW*, Mao XM*. Coordination of polyketide release and multiple detoxification pathways for tolerable production of fungal mycotoxins. Angew Chem Int Ed Engl. 2022. in press. Cao F#, Zhang MK#, Yang X, Xu CX, Cheng JT, Zhao QW, Wu R, Sheng R*, Mao XM*. A target and efficient synthetic strategy for structural and bioactivity optimization of a fungal natural product. Eur J Med Chem. 2022. 229: 114067. Cao F, Tao WT, Yu Q, Xu CX, Cheng JT, Liu RX, Zhao QW, Jiang XH, Liu Y, Li YQ, Zhan ZJ*, Shi T*, Mao XM*. Discovery of semi-pinacolases from epoxide hydrolase family during efficient assembly of a fungal polyketide. ACS Catal. 2021. 11(24): 14702-14711. Jiang YH#, Liu YF#, Wang K#, Zhou JY, Guo F, Zhao QW, Mao XM*. Fine-tuning Cas9 activity with a cognate inhibitor AcrIIA4 to improve genome editing in Streptomyces. ACS Synth Biol. 2021. 10(11):2833-2841. Cheng JT#, Wang HM#, Yu JH, Sun CF, Cao F, Jiang XH, Chen XA, Zhao QW, Gan LS, Xie RR, Wang SL, Li J, Zang Y*, Mao XM*. Discovery of a potential liver fibrosis inhibitor from a mushroom endophytic fungus by genome mining of a silent biosynthetic gene cluster. J Agric Food Chem. 2021. 69(38): 11303–11310. Cheng JT, Yu J, Sun CF, Cao F, Ying YM, Zhan ZJ, Li W, Chen XA, Zhao QW, Li YQ*, Gan LS*, Mao XM*. A cell factory of a fungicolous fungus Calcarisporium arbuscula for efficient production of natural products. ACS Synth Biol. 2021. 10: 698-706. Sun CF, Li YQ, Mao XM*. Regulation of protein post-translational modifications on metabolism of actinomycetes. Biomolecules. 2020. 10:1122. Cheng JT, Cao F, Chen XA, Li YQ*, Mao XM*. Genomic and transcriptomic survey of an endophytic fungus Calcarisporium arbuscula NRRL 3705 and potential overview of its secondary metabolites. BMC Genomics. 2020. 21(1):424. Sun CF, Xu WF, Zhao QW, Luo S, Chen XA, Li YQ*, Mao XM*. Crotonylation of key metabolic enzymes regulates carbon catabolite repression in Streptomyces roseosporus. Commun Biol. 2020. 3: 192. Xia H, Li X, Li Z, Zhan X, Mao XM*, Li YQ*. The application of regulatory cascades in Streptomyces: yield enhancement and metabolite mining. Front Microbiol. 2020. 11:406. Xia H#, Zhan X#, Mao XM*, Li YQ*. The regulatory cascades of antibiotic production in Streptomyces. World J Microbiol Biotechnol. 2020. 36(1):13. Wang K#, Zhao QW#, Liu YF#, Sun CF, Chen XA, Burchmore R, Burgess K, Li YQ*, Mao XM*. Multi-layer controls of Cas9 activity coupled with ATP synthase over-expression for efficient genome editing in Streptomyces. Front Bioeng Biotechnol. 2019. 7:304. Guo YY, Li ZH, Xia TY, Du YL, Mao XM*, Li YQ*. Molecular mechanism of azoxy bond formation for azoxymycins biosynthesis. Nat Commun. 2019. 10(1): 4420. Wang K, Chen XA, Li YQ*, Mao XM*. Identification of a secondary metabolism-responsive promoter by proteomics for over-production of natamycin in Streptomyces. Arch Microbiol. 2019. 201:1459-1464. Li YP, Yu P, Li JF, Tang YL, Bu QT, Mao XM, Li YQ*. FadR1, a pathway-specific activator of fidaxomicin biosynthesis in Actinoplanes deccanensis Yp-1. Appl Microbiol Biotechnol. 2019. 103(18):7583-7596. Zheng Y, Sun CF, Fu Y, Chen XA, Li YQ*, Mao XM*. Dual regulation between the two-component system PhoRP and AdpA regulates antibiotic production in Streptomyces. J Ind Microbiol Biotechnol. 2019. 46(5):725-737. Bu QT, Yu P, Wang J, Li ZY, Chen XA, Mao XM*, Li YQ*. Rational construction of genome-reduced and high-efficient industrial Streptomyces chassis based on multiple comparative genomic approaches. Microb Cell Fact. 2019. 18:16. Wang K, Liu XF, Bu QT, Zheng Y, Chen XA, Li YQ*, Mao XM*. Transcriptome-based identification of a strong promoter for hyper-production of natamycin in Streptomyces. Curr Microbiol. 2019. 76(1): 95-99. He X, Zhang M, Guo YY, Mao XM, Chen XA*, Li YQ*. Revelation of the balanol biosynthetic pathway in Tolypocladium ophioglossoides. Org Lett. 2018. 20:6323-6326. Shen JJ, Chen F, Wang XX, Liu XF, Chen XA, Mao XM*, Li YQ*. Substrate specificity of acyltransferase domains for efficient transfer of acyl groups. Front Microbiol. 2018. 9: 1840.