Langer, Robert - Massachusetts Institute of Technology - Department of Chemical Engineering

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Massachusetts Institute of Technology Department of Chemical Engineering
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个人简介

Robert S. Langer is the David H. Koch Institute Professor (there are 13 Institute Professors at MIT; being an Institute Professor is the highest honor that can be awarded to a faculty member). Dr. Langer has written nearly 1,380 articles. He also has over 1,130 issued and pending patents worldwide. Dr. Langer’s patents have been licensed or sublicensed to over 300 pharmaceutical, chemical, biotechnology and medical device companies. He is the most cited engineer in history (h-index 230). He served as a member of the United States Food and Drug Administration’s SCIENCE Board, the FDA’s highest advisory board, from 1995 -- 2002 and as its Chairman from 1999-2002. Dr. Langer has received over 220 major awards. He is one of 4 living individuals to have received both the United States National Medal of Science (2006) and the United States National Medal of Technology and Innovation (2011). He also received the 2002 Charles Stark Draper Prize, considered the equivalent of the Nobel Prize for engineers, the 2008 Millennium Prize, the world’s largest technology prize, the 2012 Priestley Medal, the highest award of the American Chemical Society, the 2013 Wolf Prize in Chemistry, the 2014 Breakthrough Prize in Life Sciences and the 2014 Kyoto Prize. He is also the only engineer to receive the Gairdner Foundation International Award; 82 recipients of this award have subsequently received a Nobel Prize. In 2015, Dr. Langer received the Queen Elizabeth Prize for Engineering. Among numerous other awards Langer has received are the Dickson Prize for Science (2002), Heinz Award for Technology, Economy and Employment (2003), the Harvey Prize (2003), the John Fritz Award (2003) (given previously to inventors such as Thomas Edison and Orville Wright), the General Motors Kettering Prize for Cancer Research (2004), the Dan David Prize in Materials Science (2005), the Albany Medical Center Prize in Medicine and Biomedical Research (2005), the largest prize in the U.S. for medical research, induction into the National Inventors Hall of Fame (2006), the Max Planck Research Award (2008), the Prince of Asturias Award for Technical and Scientific Research (2008), the Warren Alpert Foundation Prize (2011) and the Terumo International Prize (2012). In 1998, he received the Lemelson-MIT prize, the world’s largest prize for invention for being “one of history’s most prolific inventors in medicine.” In 1989 Dr. Langer was elected to the National Academy of Medicine, and in 1992 he was elected to both the National Academy of Engineering and to the National Academy of Sciences, and in 2012 he was elected to the National Academy of Inventors. Forbes Magazine (1999) and Bio World (1990) have named Dr. Langer as one of the 25 most important individuals in biotechnology in the world. Discover Magazine (2002) named him as one of the 20 most important people in this area. Forbes Magazine (2002) selected Dr. Langer as one of the 15 innovators world wide who will reinvent our future. Time Magazine and CNN (2001) named Dr. Langer as one of the 100 most important people in America and one of the 18 top people in science or medicine in America (America’s Best). Parade Magazine (2004) selected Dr. Langer as one of 6 “Heroes whose research may save your life.” Dr. Langer has received honorary doctorates from Harvard University, the Mt. Sinai School of Medicine, Yale University, the University of Maryland, University of Western Ontario (Canada), the ETH (Switzerland), the Technion (Israel), the Hebrew University of Jerusalem (Israel), the Universite Catholique de Louvain (Belgium), Rensselaer Polytechnic Institute, Willamette University, the University of Liverpool (England), Bates College, the University of Nottingham (England), Albany Medical College, Pennsylvania State University, Northwestern University, Uppsala University (Sweden), Tel Aviv University (Israel), Boston University, Ben Gurion University (Israel), Carnegie Mellon University, Drexel University, Hanyang University (South Korea), University of New South Wales (Australia), Karolinska Institutet (Sweden), Hong Kong University of Science and Technology (Hong Kong) and the University of California – San Francisco Medal. He received his Bachelor’s Degree from Cornell University in 1970 and his Sc.D. from the Massachusetts Institute of Technology in 1974, both in Chemical Engineering.

研究领域

Investigating the mechanism of release from polymeric delivery systems with concomitant microstructural analysis and mathematical modeling. Studying applications of these systems including the development of effective long-term delivery systems for insulin, anti-cancer drugs, growth factors, gene therapy agents and vaccines. Developing controlled release systems that can be magnetically, ultrasonically, or enzymatically triggered to increase release rates.

近期论文

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Vegas, A., Veiseh, O., Doloff, J., Ma, M., Tam, H., Bratlie, K., Li, J., Bader, A., Langan, E., Olejnik, K., Fenton, P., Kang, J., Hollister-Locke, J., Bochenek, M., Chiu, A., Siebert, S., Tang, K., Jhunjhunwala, S., Aresta-Dasilva, S., Dholakia, N., Thakrar, R., Vietti, T., Chen, M., Cohen, J., Siniakowicz, K., Qi, M., McGarrigle, J., Lyle, S., Harlan, D., Greiner, D., Oberholzer, J., Weir, G. Langer, R. and Anderson, D., Combinatorial development of hydrogels that mitigate the foreign body response in primates, Nature Biotechnology, 34: 345-352, 2016. Yin, H., Song, C., Dorkin, J., Zhu, L., Li, Y., Wu, Q., Park, A., Yang, J., Suresh, S., Bizhanova, A., Gupta, A., Bolukbasi, M., Walsh, S., Bogorad, R., Gao, G., Weng, Z., Dong, Y., Koteliansky, V., Wolfe, S., Langer, R., Xue, W., and Anderson, D., Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo, Nature Biotechnology, 34: 328-333, 2016. Dong, Y., Dorkin, J., Wang, W., Chang, P., Webber, M., Tang, B., Abutbul-Ionita, I., Danino, D., DeRosa, F, Heartlein, M. and Langer, R., Poly(glycoamidoamine) brushes formulated nanomaterials for systemic mRNA delivery in vivo, Nano Letters, 16: 842-848, 2016. Xue, Y., Xu, X., Zhang, X., Farokhzad, O. and Langer, R., Preventing diet-induced obesity in mice by inducing adipose tissue transformation and angiogenesis using targeting nanoparticles with drug delivery amplification, Proceedings of the National Academy of Sciences, 113: 5552-5557, 2016. Webber, M., Appel, E., Meijer, E. and Langer, R., Supramolecular biomaterials, Nature Materials, 15: 13-26, 2016. Tibbitt, Mark, Dahlman, J. and Langer, R., Emerging frontiers in drug delivery, Journal of the American Chemical Society, 138: 704-717, 2016. Vegas, A., Veiseh, O., Gurtler, M., Millman, J., Pagliuca, F., Bader, A., Doloff, J., Li, J., Chen, M., Olejnik, K., Tam, H., Jhunjhunwala, S., Langan, E., Aresta-Dasilva, S., Gandham, S., McGarrigle, J., Bochenek, M., Hollister-Lock, J., Oberholzer, J., Greiner, D., Weir, G., Melton, D, Langer, R. and Anderson, D., Long-term glycemic control using polymer encapsulated human stem cell-derived beta cells in immune-competent mice, Nature Medicine, 22: 306-211, 2016. Tzeng, S., Guarecuco, R., McHugh, K., Rose, S., Rosenberg, E., Zeng, Y., Langer, R. and Jaklenec, A., Thermostabilization of inactivated polio vaccine in PLGA-based microspheres for pulsatile release, Journal of Controlled Release, 233: 101-113, 2016. Lee, H., Ahsen, O., Liang, K., Wang, Z., Cleveland, C., Booth, L., Potsaid, B., Jayaraman, V., Cable, A., Mashimo, H., Langer, R., Traverso, G. and Fujimoto, J., Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromoto balloon catheter, Biomedical Optics Express, 7: 2927-2942, 2016. Yin, H., Bogorad, R., Barnes, C., Walsh, S., Zhuang, I., Nonaka, H., Ruda, V., Kuchimanchi, S., Nechev, L., Akinc, A., Xue, W., Zerial, M., Langer, R., Anderson, D. and Koteliansky, V., RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver, Journal of Hepatology, 64: 899-907, 2016. Oudin, M., Jonas, O., Kosciuk, T., Broye, L., Wyckoff, J., Riquelme, D., Lamar, J., Asokan, S., Whittaker, C., Ma, D., Langer, R., Cima, M., Wisinski, K., Hynes, R., Lauffenburger, D., Keely, P., Bear, J. and Gertler, F., Tumor cell-driven extracellular matrix remodeling enables haptotaxis during metastatic progression, Cancer Discovery, 6: 516-531, 2016. Fischer, K., Morgan, K., Hearon, K., Sklaviadis, D., Tochka, Z., Fenton, O., Anderson, D., Langer, R. and Freed, L., Poly(limonene thioether) scaffold for tissue engineering, Advanced Healthcare Materials, 5: 813-821, 2016. Kimball, A., Javorsky, E., Ron, E., Crowley, W. and Langer, R., A novel approach to administration of peptides in women: Systemic absorption of a GnRH agonist via transvaginal ring delivery system, Journal of Controlled Release, 233: 19-28, 2016. Chahal, J., Khan, O., Cooper, C., McPartlan, J., Tsosie, J., Tilley, L., Sidik, S., Lourido, S., Langer, R., Bavari, A., Ploegh, H. and Anderson, D., Dendrimer-RNA nanoparticles generate protective immunity against lethal ebola, H1N1 influenza and toxoplasma gondii challenges with a single dose, Proceedings of the National Academy of Sciences, 113: E4133-E4142, 2016. Lee, Y., Zhang, S., Lin, J., Langer, R. and Traverso, G., A janus mucoadhesive and omniphobic device for gastrointestinal retention, Advanced Healthcare Materials, 5: 1141-1146, 2016. Sager, H., Dutta, P., Dahlman, J., Courties, G., Heidt, T., Vinegoni, C., Borodovsky, A, Fitzgerald, K., Sun, Y., Wojtkiewicz, G., Iwamoto, Y., Khan, O., Xing, Y., Shaw, T., Libby, P., Langer, R., Weissleder, R., Sirski, F., Anderson, D. and Nahrendorf, M., RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction, Science Translational Medicine, 8: 342ra80, 2016. Yang, Y., Andersson, P., Hosaka, K., Zhang, Y., Cao, R., Iwamoto, H., Yang, X., Nakamura, M., Wang, J., Zhuang, R., Morikawa, H., Xue, Y., Braun, H., Beyaert, R., Samani, N., Nakae, S., Hams, E., Dissing, S., Fallong, P., Langer, R., and Cao, Y., The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumor-associated macrophages, Nature Communications, DOI: 10.1038/ncomms11385, 2016. Chen, X., Wu, B., Jayawardana, K., Hao, N., Jayawardena, S., Langer, R., Jaklenec, A. and Yan, M., Magnetic multivalent trehalose glycopolymer nanoparticles for the detection of mycobacteria, Advanced Healthcare Materials, E-pub ahead of time, DOI:10.102/adhm.201600071, 2016. Zhao, X., Hwang, N., Bichara, D., Saris, D., Malda, J., Vacanti, J., Pomerantseva, I., Sundback, C., Langer, R., Anderson, D. and Randolph, M., Chondrogenesis by bone marrow-derived mesenchymal stem cells grown in chondrocyte-conditioned medium for auricular reconstruction, Journal of Tissue Engineering and Regenerative Medicine, E-pub ahead of time DOI: 10.1002/term.2171, 2016. Patel, A., Tibbitt, M., Celiz, M., Davies, M., Langer, R., Denning, C., Alexander, M. and Anderson, D., High throughput screening for discovery of materials that control stem cell fate, Current Opinion in Solid State and Materials Science, E-pub ahead of time, DOI:10.1016/j.cossms.2016.02.002, 2016.

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