BARKOULAS, MICHALIS - Imperial College London - Department of Life Sciences, Biology, Ecology and Environmental Biology, Microbiology, Zoology

个人简介

We use Caenorhabditis elegans and related nematodes as model systems to study the relationship between genotype and developmental phenotypes. Our aim is to understand how genetic networks, that is, the entire set of functional linkages between genes and their regulatory modules, encode developmental phenotypes, and how these networks are modified in different environments or become subject to evolutionary change via natural selection. We are particularly interested in understanding what makes developmental networks robust, so they continue producing consistent end results (i.e. phenotypes) in the presence of genetic or environmental perturbations. We would like to identify mechanisms that ensure developmental stability, study how these mechanisms evolve and address their evolutionary significance and consequences for a given system and organism. To answer our questions we use C. elegans techniques ranging from RNAi and transgenesis to single molecule imaging and CRISPR-Cas9 genome editing. I did my PhD and first Post-doc at the University of Oxford, working on plant developmental genetics. In 2009, I moved to the Félix lab at the Ecole Normale Supérieure in Paris, where I worked on C. elegans developmental robustness.

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Barkoulas M, Vargas Velazquez AM, Peluffo AE, Félix MAet al., 2016, Evolution of New cis-Regulatory Motifs Required for Cell-Specific Gene Expression in Caenorhabditis., PLoS Genet, Vol: 12 Boukhibar LM, Barkoulas M, 2016, The developmental genetics of biological robustness, ANNALS OF BOTANY, Vol: 117, Pages: 699-707, ISSN: 0305-7364 Grimbert S, Tietze K, Barkoulas M, Sternberg PW, Felix M-A, Braendle Cet al., 2016, Anchor cell signaling and vulval precursor cell positioning establish a reproducible spatial context during C. elegans vulval induction, DEVELOPMENTAL BIOLOGY, Vol: 416, Pages: 123-135, ISSN: 0012-1606 Felix M-A, Barkoulas M, 2015, Pervasive robustness in biological systems, NATURE REVIEWS GENETICS, Vol: 16, Pages: 483-496, ISSN: 1471-0056 Matus DQ, Lohmer LL, Kelley LC, Schindler AJ, Kohrman AQ, Barkoulas M, Zhang W, Chi Q, Sherwood DRet al., 2015, Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression, DEVELOPMENTAL CELL, Vol: 35, Pages: 162-174, ISSN: 1534-5807 van Zon JS, Kienle S, Huelsz-Prince G, Barkoulas M, van Oudenaarden Aet al., 2015, Cells change their sensitivity to an EGF morphogen gradient to control EGF-induced gene expression., Nature Communications, Vol: 6, Pages: 7053-7053, ISSN: 2041-1723 Hay AS, Pieper B, Cooke E, Mandáková T, Cartolano M, Tattersall AD, Ioio RD, McGowan SJ, Barkoulas M, Galinha C, Rast MI, Hofhuis H, Then C, Plieske J, Ganal M, Mott R, Martinez-Garcia JF, Carine MA, Scotland RW, Gan X, Filatov DA, Lysak MA, Tsiantis Met al., 2014, Cardamine hirsuta: a versatile genetic system for comparative studies., Plant J, Vol: 78, Pages: 1-15 Barkoulas M, van Zon JS, Milloz J, van Oudenaarden A, Félix MAet al., 2013, Robustness and epistasis in the C. elegans vulval signaling network revealed by pathway dosage modulation., Dev Cell, Vol: 24, Pages: 64-75 Félix MA, Barkoulas M, 2012, Robustness and flexibility in nematode vulva development., Trends Genet, Vol: 28, Pages: 185-195, ISSN: 0168-9525 Bilsborough GD, Runions A, Barkoulas M, Jenkins HW, Hasson A, Galinha C, Laufs P, Hay A, Prusinkiewicz P, Tsiantis Met al., 2011, Model for the regulation of Arabidopsis thaliana leaf margin development., Proc Natl Acad Sci U S A, Vol: 108, Pages: 3424-3429 Hoyos E, Kim K, Milloz J, Barkoulas M, Pénigault JB, Munro E, Félix MAet al., 2011, Quantitative variation in autocrine signaling and pathway crosstalk in the Caenorhabditis vulval network., Curr Biol, Vol: 21, Pages: 527-538 Prasad K, Grigg SP, Barkoulas M, Yadav RK, Sanchez-Perez GF, Pinon V, Blilou I, Hofhuis H, Dhonukshe P, Galinha C, Mähönen AP, Muller WH, Raman S, Verkleij AJ, Snel B, Reddy GV, Tsiantis M, Scheres Bet al., 2011, Arabidopsis PLETHORA transcription factors control phyllotaxis., Curr Biol, Vol: 21, Pages: 1123-1128 Canales C, Barkoulas M, Galinha C, Tsiantis Met al., 2010, Weeds of change: Cardamine hirsuta as a new model system for studying dissected leaf development., J Plant Res, Vol: 123, Pages: 25-33 Scarpella E, Barkoulas M, Tsiantis M, 2010, Control of leaf and vein development by auxin., Cold Spring Harb Perspect Biol, Vol: 2 Barkoulas M, Hay A, Kougioumoutzi E, Tsiantis Met al., 2008, A developmental framework for dissected leaf formation in the Arabidopsis relative Cardamine hirsuta., Nat Genet, Vol: 40, Pages: 1136-1141, ISSN: 1061-4036 Barkoulas M, Galinha C, Grigg SP, Tsiantis Met al., 2007, From genes to shape: regulatory interactions in leaf development., Curr Opin Plant Biol, Vol: 10, Pages: 660-666, ISSN: 1369-5266 Hay A, Barkoulas M, Tsiantis M, 2006, ASYMMETRIC LEAVES1 and auxin activities converge to repress BREVIPEDICELLUS expression and promote leaf development in Arabidopsis., Development, Vol: 133, Pages: 3955-3961, ISSN: 0950-1991 Hay A, Barkoulas M, Tsiantis M, 2004, PINning down the connections: transcription factors and hormones in leaf morphogenesis., Curr Opin Plant Biol, Vol: 7, Pages: 575-581, ISSN: 1369-5266