Nowlan, Niamh - Imperial College London - Department of Bioengineering

个人简介

Dr. Niamh Nowlan’s research is in the biomechanics of fetal movements, with particular focus on the role of fetal movements in normal skeletal development, and the importance of fetal movements as a measure for fetal health. For more details on the research being done in the Nowlan Lab, please visit the Research Pages. Prior to joining Imperial College in 2011, Dr. Nowlan held two postdoctoral fellowships in Trinity College Dublin, Ireland and in the Centre for Genomic Research, Barcelona, Spain. In 2009, Dr. Nowlan travelled to the USA as a Fulbright scholar, and spent six months working in Boston University. Dr. Nowlan obtained a PhD in Bioengineering from Trinity College Dublin, Ireland in 2007, and holds a degree in Computer Engineering

研究领域

Dr. Niamh Nowlan combines experimental and computational approaches to the study of the role of mechanical forces on prenatal skeletal development. When there is not enough movement in the womb, bones and joints can be severely affected, but the underlying reasons are not well understood. It is unclear how much movement, and what type of movements, are important for normal development of the skeleton. The multidisciplinary research being conducted by Dr. Nowlan and her research team will enhance our fundamental understanding of the role of mechanical forces on the formation, adaptation and maintenance of healthy cartilage and bone.

近期论文

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Chandaria VV, McGinty J, Nowlan NC, 2016, Characterising the effects of in vitro mechanical stimulation on morphogenesis of developing limb explants., J Biomech Ford CA, Nowlan NC, Thomopoulos S, Killian MLet al., 2016, Effects of imbalanced muscle loading on hip joint development and maturation., J Orthop Res Lai J, Nowlan NC, Vaidyanathan R, Shaw CJ, Lees CCet al., 2016, Fetal movements as a predictor of health., Acta Obstet Gynecol Scand, Vol: 95, Pages: 968-975 Verbruggen SW, Loo JHW, Hayat TTA, Hajnal JV, Rutherford MA, Phillips ATM, Nowlan NCet al., 2016, Modeling the biomechanics of fetal movements, BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, Vol: 15, Pages: 995-1004, ISSN: 1617-7959 Bowles C, Nowlan NC, Hayat TTA, Malamateniou C, Rutherford M, Hajnal JV, Rueckert D, Kainz Bet al., 2015, Machine learning for the automatic localisation of foetal body parts in cine-MRI scans, Conference on Medical Imaging - Image Processing, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X Giorgi M, Carriero A, Shefelbine SJ, Nowlan NCet al., 2015, Effects of normal and abnormal loading conditions on morphogenesis of the prenatal hip joint: application to hip dysplasia, JOURNAL OF BIOMECHANICS, Vol: 48, Pages: 3390-3397, ISSN: 0021-9290 Nowlan NC, 2015, Biomechanics of foetal movement., Eur Cell Mater, Vol: 29, Pages: 1-21 Giorgi M, Carriero A, Shefelbine SJ, Nowlan NCet al., 2014, Mechanobiological simulations of prenatal joint morphogenesis, JOURNAL OF BIOMECHANICS, Vol: 47, Pages: 989-995, ISSN: 0021-9290 Nowlan NC, Chandaria V, Sharpe J, 2014, Immobilized chicks as a model system for early-onset developmental dysplasia of the hip., J Orthop Res, Vol: 32, Pages: 777-785 Rolfe RA, Nowlan NC, Kenny EM, Cormican P, Morris DW, Prendergast PJ, Kelly D, Murphy Pet al., 2014, Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways, BMC GENOMICS, Vol: 15, ISSN: 1471-2164 Nowlan NC, Sharpe J, 2013, Joint shape morphogenesis precedes cavitation of the developing hip joint, Journal of Anatomy, ISSN: 0021-8782 Nowlan NC, Dumas G, Tajbakhsh S, Prendergast PJ, Murphy Pet al., 2012, Biophysical stimuli induced by passive movements compensate for lack of skeletal muscle during embryonic skeletogenesis., Biomech Model Mechanobiol, Vol: 11, Pages: 207-219 Nowlan NC, Jepsen KJ, Morgan EF, 2011, Smaller, Weaker and Less Stiff Bones Evolve from Changes in Lifestyle, Osteoporosis International, Vol: 22, Pages: 1967-1980 Nowlan NC, Bourdon C, Dumas G, Tajbakhsh S, Prendergast PJ, Murphy Pet al., 2010, Developing bones are differentially affected by compromised skeletal muscle formation., Bone, Vol: 46, Pages: 1275-1285 Nowlan NC, Sharpe J, Roddy KA, Prendergast PJ, Murphy Pet al., 2010, Mechanobiology of embryonic skeletal development: Insights from animal models., Birth Defects Res C Embryo Today, Vol: 90, Pages: 203-213 Nowlan NC, Prendergast PJ, Tajbakhsh S, Murphy Pet al., 2009, Identifying candidate mechanoregulators of skeletal development, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, Pages: 149-150 Roddy KA, Nowlan NC, Prendergast PJ, Murphy Pet al., 2009, 3D representation of the developing chick knee joint: a novel approach relating multiple components, Journal of Anatomy, Vol: 214, Pages: 374-387 Foolen J, van Donkelaar CC, Murphy P, Nowlan NC, Huiskes R, Ito Ket al., 2008, Collagen orientation in periosteum and perichondrium is aligned with preferential directions of tissue growth, Journal of Orthopaedic Research, Vol: 26, Pages: 1263-1268 Nowlan NC, Murphy P, Prendergast PJ, 2008, A dynamic pattern of mechanical stimulation promotes ossification in avian embryonic long bones., J Biomech, Vol: 41, Pages: 249-258, ISSN: 0021-9290 Nowlan NC, Prendergast PJ, Murphy P, 2008, Identification of mechanosensitive genes during embryonic bone formation., PLoS Comput Biol, Vol: 4