张强哲 - 南开大学

个人简介

学科方向：肿瘤药理与病理学教师简介：张强哲， 2011年7月毕业于中国科学院生物物理研究所，获理学博士学位。主要从事肿瘤及血管细胞生物学相关研究。曾经主持和参与完成国家自然科学基金、国家863项目、中国科学院战略性先导科技专项、国际科技合作项目等多项。讲授本科生《生物化学》以及研究生《肿瘤药理学》等课程。

研究领域

肿瘤干细胞及血管生物学

近期论文

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1. Zhang Changyu#; Zhang Qiang-Zhe#; Zhang Kun#; Li Lu-Yuan*; Michael D. Pluth; Yi Long*; Xi Zhen*, Dual-biomarker-triggered fluorescence probes for differentiating cancer cells and revealing synergistic antioxidant effects under oxidative stress, Chemical Science, 2019, 10, 1945~1952 (Co-first author) 2.Peng Xue-mei; Gao Shan; Deng Hui-Ting; Cai Hong-Xing; Zhou Zhuan; Xiang Rong; Zhang Qiang-Zhe*; Li Lu-Yuan*, Perturbation of epithelial apicobasal polarity by rhomboid family-1 gene overexpression, FASEB J, 2018.10.1, 32(10)：5577~5586 (Co-corresponding author) 3.Longhuai Cheng#, Huiting Deng#, Dejun Ma, Beibei Zhai, Qiangzhe Zhang*, Luyuan Li*, Zhen Xi*. Branch-PCR constructed TP53 gene nanovector for potential cancer therapy. Chem Commun (Camb). 2018 Aug 23; 54(69): 9687-90. (Co-corresponding author) 4.Zhang Kun#; Zhang Jie#; Xi Zhen; Li Lu-Yuan; Gu Xiangxiang; Zhang Qiang-Zhe*; Yi Long*, A new H2S-specific near-infrared fluorescence-enhanced probe that can visualize the H2S level in colorectal cancer cells in mice, Chemical Science, 2017.4.1, 8(4)：2776~2781 (Co-corresponding author) 5. Zhang Changyu#; Zhai Bei-Bei#; Peng Tao; Zhong Zelin; Xu Lianbin; Zhang Qiang-Zhe*; Li Lu-Yuan; Yi Long*; Xi Zhen, Design and synthesis of near-infrared fluorescence-enhancement probes for the cancer-specific enzyme hNQO1, Dyes and Pigments, 2017.8.1, 143：245~251 (Co-corresponding author) 6.Hui-Ting Deng, Hai-Lin Liu, Bei-Bei Zhai, Kun Zhang, Guo-Ce Xu, Xue-Mei Peng, Qiang-Zhe Zhang*, and Lu-Yuan Li*. VEGF Suppresses TNFSF15 Production in Endothelial Cells by Stimulating miR-31 and miR-20a Expression via Activation of Akt and Erk Signals. FEBS Open Bio. FEBS Open Bio, 2017, 7(1)：108~117. (Co-corresponding author) 7. Li DZ#, Zhang QZ#, Wang CY#, Zhang YL#, Li XY, Huang JT, Liu HY, Fu ZD, Song HX, Lin JP, Ji TF, Pan XD. Synthesis and antitumor activity of novel substituted uracil-1'(N)-acetic acid ester derivatives of 20(S)-camptothecins. Eur J Med Chem. 2016 Nov 8; 125: 1235-1246. (Co-first author) 8. Zhang K, Cai HX, Gao S, Yang GL, Deng HT, Xu GC, Han J, Zhang QZ*, Li LY*. TNFSF15 suppresses VEGF production in endothelial cells by stimulating miR-29b expression via activation of JNK-GATA3 signals. Oncotarget. 2016 7(43): 69436-49. (Co-corresponding author) 9. Wei C, Wang R, Zhang C, Xu G, Li Y, Zhang QZ, Li LY, Yi L, Xi Z. Dual-Reactable Fluorescent Probes for Highly Selective and Sensitive Detection of Biological H2 S. Chem Asian J. 2016 May 6;11(9):1376-81. 10. Wang R, Li Z, Zhang C, Li Y, Xu G, Zhang QZ, Li LY, Yi L, Xi Z. Fast-Response Turn-on Fluorescent Probes Based on Thiolysis of NBD Amine for H2 S Bioimaging. Chembiochem. 2016 May 17;17(10):962-8. 11. Qin TT, Xu GC, Qi JW, Yang GL, Zhang K, Liu HL, Xu LX, Xiang R, Xiao G, Cao H, Wei Y, Zhang QZ*, Li LY*.. Tumor necrosis factor superfamily member 15 (Tnfsf15) facilitates lymphangiogenesis via upregulation of Vegfr3 gene expression in lymphatic endothelial cells. J. Pathol. 2015, 237: 307–318. (Co-corresponding author) 12. Zhang Q#, Zhang C#, Gao M, He X, Diao Y, Goyal SM, Mor SK, Huang J*. Evolutionary, epidemiological, demographical, and geographical dissection of porcine bocavirus in China and America. Virus Res. 2015 Jan 2;195:13-24. (Co-first author) 13. Zhang C#, Zhang Q*. Tumor microenvironment research in China. Journal of Chemical and Pharmaceutical Research. 2014, 6(3): 1428-1433. 14. Jiang J, Han P, Zhang Q, Zhao J, Ma Y, Mercola M. Cardiac differentiation of human pluripotent stem cells. J Cell Mol Med. 2012 Aug;16(8):1663-8. 15. Zhang Q#, Jiang J#, Han P#, Yuan Q, Zhang J, Zhang X, Xu Y, Cao H, Meng Q, Chen L, Tian T, Wang X, Li P, Hescheler J, Ji G, Ma Y. Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals. Cell Res. 2011 Apr;21(4):579-87.（cover story, Co-first author） 16. Zhang Q#, Zhang C#, Xi Z. Enhancement of RNAi by a small molecule antibiotic enoxacin. Cell Res. 2008 Oct;18(10):1077-9. (Co-first author)