山长亮 - 南开大学

个人简介

南开大学百名青年学科带头人学科方向：肿瘤药理、分子生物学和细胞生物学教育背景 2011年获南开大学生物化学与分子生物学博士 2006年获鲁东大学生物技术本科工作经历 2018年12月~至今南开大学药学院教授博导 2015年6月~2018年11月暨南大学生物医学转化研究院研究员博导 2015年1月~2015年5月上海药物研究所客座研究员 2011年9月~2014年12月美国Emory 大学医学院博后个人专长山长亮博士长期从事肿瘤代谢酶调控与化学干预研究。发表学术论文50余篇，其中以第一（共同）和通讯作者发表论文21篇，包括Nature Cell Biology, Nature Chemistry, Molecular Cell (2篇), Clinical and Translational Medicine, Cancer Letter, J. Biol. Chem, Cell Research, Biochemical Pharmacology (2篇), Cell Death & Disease (2篇), Biomedicines, Carcinogenesis (2篇), European Journal of Medicinal Chemistry, FEBS Lett, Bioorg Med Chem Lett和Front. Pharmacol (3篇)。

研究领域

肿瘤代谢酶表观调控与化学干预

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Wang J, Qiao Y, Sun M, Sun H, Xie F, Chang H, Wang Y, Song J, Lai S, Yang C, Li X, Liu S, Zhao X, Ni K, Meng K, Zhang S*, Shan C*, Zhang C*, FTO promotes colorectal cancer progression and chemotherapy resistance via demethylating G6PD/PARP1.Clinical and Translational Medicine.2022. DOI: 10.1002/ctm2.772 2. Wang J, Qiao Y, Sun H, Chang H, Zhao H, Zhang S*, Shan C*. Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma. Biomedicines. 2022 Jan 22;10(2):234. doi: 10.3390/biomedicines10020234. 3. Sun M, Sheng H, Wu T, Song J, Sun H, Wang Y, Wang J, Li Z, Zhao H, Tan J, Li Y, Chen G, Huang Q, Zhang Y, Lan B, Liu S*, Shan C*, Zhang S*. PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3. Biochem Pharmacol. 2021 Oct;192:114736. doi: 10.1016/j.bcp.2021.114736. Epub 2021 Aug 16. 4. Luo Z, Du D, Liu Y, Lu T, Liu L, Jiang H, Chen K, Shan C*, Luo C*. Discovery and characterization of a novel glucose-6-phosphate dehydrogenase (G6PD) inhibitor via high-throughput screening. Bioorg Med Chem Lett. （2021） May 15;40:127905. 5. Feng Q, Li X, Sun W, Sun M, Li Z, Sheng H, Xie F, Zhang S*, Shan C*. Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1. Biochem Pharmacol. 2020 Aug;178:114092. doi: 10.1016/j.bcp.2020.114092. Epub 2020 Jun 11. 6. Sheng H, Li Z, Su S, Sun W, Zhang X, Li L, Li J, Liu S, Lu B, Zhang S*, Shan C*. YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation. Carcinogenesis. 2020 Jul 10;41(5):541-550. doi: 10.1093/carcin/bgz152. 7. Li Y, Liang R, Sun M, Li Z, Sheng H, Wang J, Xu P, Liu S, Yang W, Lu B, Zhang S*, Shan C*. AMPK-dependent phosphorylation of HDAC8 triggers PGM1 expression to promote lung cancer cell survival under glucose starvation. Cancer Lett. 2020 May 28;478:82-92. doi: 10.1016/j.canlet.2020.03.007. Epub 2020 Mar 20. 8. Shan C*,#, Lu Z, Li Z, Sheng H, Fan J, Qi Q, Liu S, Zhang S*. 4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis. Cell Death Dis. 2019 Jul 8;10(7):525. doi: 10.1038/s41419-019-1756-1. 9. Huang K, Jiang L, Liang R, Li H, Ruan X, Shan C*, Ye D*, Zhou L*. Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment. Eur J Med Chem. 2019 Apr 15;168:45-57. doi: 10.1016/j.ejmech.2019.01.085. Epub 2019 Feb 8. 10. Li Y, Liang R, Zhang X, Wang J, Shan C*, Liu S*, Li L*, Zhang S*. Copper Chaperone for Superoxide Dismutase Promotes Breast Cancer Cell Proliferation and Migration via ROS-Mediated MAPK/ERK Signaling. Front Pharmacol. 2019 Apr 5;10:356. doi: 10.3389/fphar.2019.00356. eCollection 2019. 11. Zhang S, Sheng H, Zhang X, Qi Q, Chan CB, Li L, Shan C*, Ye K*. Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation. Cell Death Dis. 2019 Mar 4;10(3):222. doi: 10.1038/s41419-019-1452-1. 12. Lu Z, Guo Y, Zhang X, Li J, Li L, Zhang S*, Shan C*. ORY-1001 Suppresses Cell Growth and Induces Apoptosis in Lung Cancer Through Triggering HK2 Mediated Warburg Effect. Front Pharmacol. 2018 Dec 4;9:1411. doi: 10.3389/fphar.2018.01411. eCollection 2018. 13. Zheng W, Feng Q, Liu J, Guo Y, Gao L, Li R, Xu M, Yan G, Yin Z, Zhang S*, Liu S*, Shan C*. Inhibition of 6-phosphogluconate Dehydrogenase Reverses Cisplatin Resistance in Ovarian and Lung Cancer. Front Pharmacol. 2017 Jun 30;8:421. doi: 10.3389/fphar.2017.00421. eCollection 2017. 14. Wang J#, Luo C#, Shan C#, You Q#, Lu J, Elf S, Zhou Y, Wen Y, Vinkenborg JL, Fan J, Kang H, Lin R, Han D, Xie Y, Karpus J, Chen S, Ouyang S, Luan C, Zhang N, Ding H, Merkx M, Liu H, Chen J, Jiang H, He C. Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation. Nat Chem. 2015 Dec;7(12):968-79. doi: 10.1038/nchem.2381. Epub 2015 Nov 9. 15. Lin R#, Elf S#, Shan C#, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96. doi: 10.1038/ncb3255. Epub 2015 Oct 19. 16. Shan C#, Elf S#, Ji Q, Kang HB, Zhou L, Hitosugi T, Jin L, Lin R, Zhang L, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. Mol Cell. 2014 Aug 21;55(4):552-65. doi: 10.1016/j.molcel.2014.06.020. Epub 2014 Jul 17. 17. Shan C, Kang HB, Elf S, Xie J, Gu TL, Aguiar M, Lonning S, Hitosugi T, Chung TW, Arellano M, Khoury HJ, Shin DM, Khuri FR, Boggon TJ, Fan J. Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth. J Biol Chem. 2014 Aug 1;289(31):21413-22. doi: 10.1074/jbc.M114.581124. Epub 2014 Jun 24. 18. Fan J#, Shan C#, Kang HB#, Elf S, Xie J, Tucker M, Gu TL, Aguiar M, Lonning S, Chen H, Mohammadi M, Britton LM, Garcia BA, Alečković M, Kang Y, Kaluz S, Devi N, Van Meir EG, Hitosugi T, Seo JH, Lonial S, Gaddh M, Arellano M, Khoury HJ, Khuri FR, Boggon TJ, Kang S, Chen J. Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex. Mol Cell. 2014 Feb 20;53(4):534-48. doi: 10.1016/j.molcel.2013.12.026. Epub 2014 Jan 30. 19. Shan C#, Zhang S, Cui W, You X, Kong G, Du Y, Qiu L, Ye L, Zhang X. Hepatitis B virus X protein activates CD59involving DNA binding and let-7i in protection of hepatoma and hepatic cellsfrom complement attack. Carcinogenesis. 2011, 32(8):1190-7. 20. Shan C#, Xu F. Zhang S, You J, You X, Qiu L, Zheng J, Ye L, Zhang X. Hepatitis B virus X protein promotes livercell proliferation via a positive cascade loop involving arachidonic acidmetabolism and p-ERK1/2. Cell Res. 2010, 20(5):563-75. 21. Zhang,S#, Shan C#, Cui W, You X, DuY, Kong G, Gao F, Ye L, Zhang X. Hepatitis B virus X protein protects hepatoma and hepatic cells from complement-dependent cytotoxicity by up-regulation of CD46. FEBS Lett. 2013,587(6):645-51.

学术兼职

中国抗癌协会抗癌药物专业委员会第六、七届委员会委员中国抗癌协会肿瘤标志专业委员会青年委员中国细胞生物学学会肿瘤细胞生物学学会分会委员中国细胞生物学学会细胞代谢分会委员中国抗癌协会肿瘤细胞代谢分会委员中国抗癌协会非编码RNA与肿瘤研究专家委员会常委