林建平 - 南开大学 - 药物化学生物学国家重点实验室

个人简介

学科方向药物设计的结构基础林建平，1997年获北京大学化学系学士学位；2000年获北京大学高分子化学硕士学位；2005年获杜克大学理论生物物理和化学博士学位。曾担任美国希望之城医学中心贝克曼研究所 (Beckman Research Institute of City of Hope)博士后研究员、杜克大学博士后助理研究员。2009年回国任南开大学药学院教授、博士生导师、任药物化学生物学国家重点实验室（南开大学）PI。林建平实验室主要研究工作集中在计算生物学方向。主要有以下两方向：（1）对复杂生物体系如DNA六元纳米管、GPCR、核蛋白等进行模拟，解释其生物现象。（2）计算机辅助药物设计包括发展药物设计方法如粗粒化对接、靶标预测方法。并针对多个体系进行多级虚拟筛选并找到超过10个苗头化合物。蛋白体系包括：HIV-1蛋白酶、HCVNS5B聚合酶、PAD4等。发表论文30篇，主要发表在Science、PCCP、Scientific Reports、 Journal of Cheminformatics、Plos one、European JMC等

研究领域

计算生物学（计算机辅助药物设计，生物大分子模拟，蛋白质电子转移）

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Hengkai Meng, Pi Liu, Hongbing Sun, Zhen Cai, Jie Zhou*, Jianping Lin*, Yin Li*, Engineering a D-lactate dehydrogenase that can superefficiently utilize NADPH and NADH as cofactors, Sci. Rep. 2016, 6: 24887. 2. Zhonghua Wang, Lu Liang, Zheng Yin, Jianping Lin*, Improving chemical similarity ensemble approach in target prediction, J. Cheminf. 2016, 8: 20. 3. Yang Li, Jixue Sun, Dongmei Li*, Jianping Lin*, Activation and conformational dynamics of a classB G-protein-coupled glucagon receptor, Phys. Chem. Chem. Phys. 2016, 18: 12642-12650. 4. Wei, Yu, Jinlong Li, Jie Qing, Mingjie Huang, Ming Wu, Fenghua Gao, Dongmei Li, Zhangyong Hong, Lingbao Kong*, Weiqiang Huang*, Jianping Lin*, Discovery of novel hepatitis C virus NS5B polymerase inhibitors by combining random forest, multiple e-pharmacophore modeling and docking, PLoS ONE 2016, 11: e0148181. 5. Qiaoyun Guo, Yu Wei, Bin Xia, Yongxin Jin, Chang Liu, Xiaolei Pan, Jing Shi, Feng Zhu, Jinlong Li, Lei Qian, Xinqi Liu, Zhihui Cheng, Shouguang Jin*, Jianping Lin*, Weihui Wu*, Identification of a small molecule that simultaneously suppresses virulence and antibiotic resistance of Pseudomonas aeruginosa, Sci. Rep. 2015, 6: 19141. 6. Han, Li, Pi Liu, Jixue Sun, Yuanqing Wu, Yuanyuan Zhang, Wujiu Chen, Jianping Lin*, Qinhong Wang*, Yanhe Ma, Engineering catechol 1, 2-cioxygenase by cesign for improving the performance of the cis, cis-muconic acid synthetic pathway in escherichia coli, Sci. Rep. 2015, 5: 13435. 7. Pi Liu, Zhonghua Wang, Lijie Zhang, Dongmei Li*, Jianping Lin*, The mechanism by which 146-N-glycan affects the active site of neuraminidase, PLoS ONE 2015, 10: e0135487. 8. Wei, Yu, Jinlong Li, Zeming Chen, Fengwei Wang, Weiqiang Huang*, Zhangyong Hong*, Jianping Lin*, Multistage virtual screening and identification of novel HIV-1 protease inhibitors by integrating SVM, shape, pharmacophore and docking methods, Eur. J. Med. Chem. 2015, 101: 409-418. 9. Junli Xu, Zhonghua Wang, Pi Liu*, Dongmei Li*, Jianping Lin*, An insight into antagonist binding and induced conformational dynamics of class B GPCR corticotropin-releasing factor receptor 1, Mol. BioSyst. 2015, 11, 2042-2050. 10. Huo, Tong, Wei Liu, Yu Guo, Cheng Yang, Jianping Lin*, Zihe Rao. Prediction of host-pathogen protein interactions between Mycobacterium tuberculosis and Homo sapiens using sequence motifs, BMC Bioinform. 2015, 16: 100. 11. Zhonghua Wang, J. Li, Ruoyu Dang, Lu Liang, Jianping Lin， PhIN: A protein pharmacology interaction network database, CPT Pharmacometrics Syst. Pharmacol. 2015, 4: 160–166. 12. Dongmei Li*, Cui Liu, Jianping Lin*, Theoretical study of the mechanism of protein arginine deiminase 4 (PAD4) inhibition by F-amidine, J. Mol. Graph. Model. 2015, 55, 25-32. 13. Zhihui Yan, Lijie Zhang, Haiyang Fu, Zhonghua Wang, Jianping Lin*, Design of the influenza virus inhibitors targeting the PA endonuclease using 3D-QSAR modeling, side-chain hopping, and docking, Bioorg. Med. Chem. Lett. 2014, 24: 539-547. 14. Li Han, Pi Liu, Y. Peng, Jianpign Lin*, Qinhong Wang* Yanhe Ma, Engineering the biosynthesis of novel rhamnolipids in Escherichia coli for enhanced oil recovery, J. Appl. Microbio. 2014, 117: 139-150. 15. Feng Sang, Peng Feng, Jie Chen, Yahui Ding, Xiyan Duan, Jiadai Zhai, Xiaoyan Ma, Bin Zhang, Quan Zhang, Jianping Lin*, Yue Chen*, Epothilone D and its 9-Methyl analogues: Combinatorial syntheses, conformation, and biological activities, Eur. J. Med. Chem. 2013, 68: 321-332. 16. Huo, Tong, Yinjie Zhang, Jianping Lin*. Functional annotation from the genome sequence of the giant panda.” Protein Cell 2012, 3: 602-608. 17. Jianping Lin*, Pi Liu, Hua-Zheng Yang, Vaidehi Nagarajan*, Factors that affect the computational prediction of hot spots in protein-protein complexes, Comput. Mol. Biosci. 2012, 2: 23-34. 18. Jianping Lin, Ralf Buettner, Yate-Ching Yuan, Richard Yip, David Horne, Richard Jove, Nagerajan Vaidehi*, Molecular dynamics simulations of the conformational changes in signal transducers and activators of transcription, Stat1 and Stat3, J. Mole. Graphics Model. 2009, 28: 347-356. 19. Jianping Lin, Nadrian C. Seeman, Nagarajan Vaidehi*, Molecular dynamics simulations of insertion of chemically modified DNA nanostructures into water-chloroform interface, Biophys. J. 2008, 95: 1099-1107. 20. Jianping Lin, Ilya A. Balabin, David N. Beratan*, The nature of aqueous tunneling pathways between electron-transfer proteins” Science 2005, 310: 1311-1313. Related news: “Water can ease electron transfer between proteins” Chemical & Engineering News, November 28, 2005, Page 11. 21. Jianping Lin, David N. Beratan*, Simulation of electron transfer between cytochrome c2 and the bacterial photosynthetic reaction center: Brownian dynamics analysis of the native proteins and double mutants, J. Phys. Chem. B 2005, 109: 7529-7534. 22. Jianping Lin, David N. Beratan*, Tunneling while pulling: The dependence of tunneling current on end-to-end distance in a flexible molecule, J. Phys. Chem. A 2004, 108: 5655-5661. 23. James C. Sung, Jianping Lin. Diamond Nanotechnology: Synthesis and applications, Pan Stanford Publishing, 2009. 24. Spiros S. Skourtis, Jianping Lin; David N. Beratan. The Effects of Bridge Motion on Electron Transfer Reactions Mediated by Tunneling, Chapter 18 in Modern Methods for Theoretical Physical Chemistry of Biopolymers. Edited By E. B. Starikov; S. Tanaka; J. P. Lewis, Elsevier Press, June 2006.