Parri, Rhein - Aston University - School of Life & Health Sciences, Pharmacy

个人简介

2012- Senior Lecturer in Pharmacology, Aston University. 2004-2012 Lecturer in Pharmacology, Aston University. 1995-2004 School of Biosciences, Cardiff University. 1992-1995 Department of Pharmacology, University of California at San Francisco. 1988-1992 Department of Neurophysiology, Southampton University.

研究领域

In recent years it has become clear that in addition to their traditional roles as “housekeepers” of the brain’s environment, astrocytes can also signal to neurones using many of the mechanisms previously thought exclusive to neuronal transmission. The release of such transmitters as glutamate and ATP can elicit and affect neuronal excitability and modulate synaptic transmission. The focus of my research is on the mechanisms of astrocyte-neuron signalling in the thalamus, and how such signalling is involved in thalamic function. The techniques used are combined electrophysiological recording and Calcium imaging.

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Stem Cell-derived astrocytes: Are they physiologically credible? Hill, E., Nagel D., Parri R., Coleman M. J Physiol. 2015 Dec 4. doi: 10.1113/JP270658. Astrocyte and neuronal plasticity in the somatosensory system. Sims RE, Butcher JB, Parri HR, Glazewski S. Neural Plast. 2015;2015:732014. doi: 10.1155/2015/732014. Epub 2015 Aug 4 Amyloid β 1-42 induces hypometabolism in human stem cell-derived neuron and astrocyte networks. Marta A Tarczyluk, David A Nagel, H R. Parri, Erin HY Tse, James E Brown, Michael D Coleman and Eric J Hill. J Cereb Blood Flow Metab. 2015 April; doi: 10.1038/jcbfm.2015.58. A predictive in vitro model of the impact of drugs with anticholinergic properties on human neuronal and astrocytic systems.Woehrling EK, Parri HR, Tse EH, Hill EJ, Maidment ID, Fox GC, Coleman MD. PLoS One. 2015 Mar 4;10(3):e0118786. doi: 10.1371/journal.pone.0118786. eCollection 2015 Gould T, Chen L, Emri Z, Pirttimaki T, Errington AC, Crunelli V, Parri HR. (2014) GABAB receptor-mediated activation of astrocytes by gamma-hydroxybutyric acid. Philos Trans R Soc Lond B Biol Sci. Oct 19;369(1654). pii: 20130607. doi: 10.1098/rstb.2013.0607 Crunelli, V., Di Giovanni, G., Parri, H.R., Errington, A.Gain of Function of thalamic extrasynaptic GABA-A receptors in typical absence seizures. in Extrasynaptic GABAA Receptors, (2014) p223-238, Springer, ISBN 978-1-4939-1426-5. Pirttimaki TM, Codadu NK, Awni A, Pratik P, Nagel DA, Hill EJ, Dineley KT, Parri HR. (2013). α7 Nicotinic Receptor-Mediated Astrocytic Gliotransmitter Release: Aβ Effects in a Preclinical Alzheimer's Mouse Model. PLoS One. 2013 Nov 28;8(11):e81828. doi: 10.1371/journal.pone.0081828 Pirttimaki TM, Parri HR.(2013) Astrocyte plasticity: implications for synaptic and neuronal activity. Neuroscientist. Dec;19(6):604-15. doi: 10.1177/1073858413504999. Epub 2013 Oct 10. Parri HR.(2013) Star spangled manner: astrocytes and neurons contribute to adenosine release in the hippocampus. J Physiol. Aug 15;591(Pt 16):3805-6. doi: 10.1113/jphysiol.2013.259838. Tarczyluk MA, Nagel DA, O'Neil JD, Parri HR, Tse EH, Coleman MD, Hill EJ. Functional astrocyte-neuron lactate shuttle in a human stem cell-derived neuronal network.J Cereb Blood Flow Metab. Sep;33(9):1386-93. doi: 10.1038/jcbfm.2013.81. Epub 2013 May 29. Pirttimaki T, Parri HR, Crunelli V. (2013) Astrocytic GABA transporter GAT-1 dysfunction in experimental absence seizures. J Physiol. 2013 Feb 15;591(Pt 4):823-33. doi: 10.1113/jphysiol.2012.242016. Epub 2012 Oct 22. Hill, E.J.,Jimenez-Gonzalez,C.M., Tarczyzluk,M., Coleman,M.D. & Parri, H.R. (2012). NT2 derived neuronal and astrocytic network signalling. PLoS One.2012;7(5):e36098. Matthew T. Conner, Alex C. Conner, Charlotte E. Bland, Luke H.J. Taylor, James E.P. Brown, H. Rheinallt Parri, and Roslyn M. Bill. (2012). Rapid aquaporin trafficking regulates cellular water flow: the mechanism of hypotonicity-induced sub-cellular localization of the aquaporin 1 water channel. J.Biol.Chem. J Biol Chem. 2012 Feb 9. Pirttimaki, T.M. & Parri, H.R. (2012). Glutamatergic Input-Output properties of thalamic astrocytes. Neuroscience. dx.doi.org/10.1016/j.neuroscience.2011.12.049. 2012 Mar 15;205:18-28. Epub 2012 Jan 3 Pirttimaki T., Hall, S.D., Parri, H.R. (2011) Sustained neuronal activity generated by glial plasticity. Journal of Neuroscience. 2011 May;31(21):7637-7647. Jimenez-Gonzalez, C.M, Pirttimaki, T., Cope D.W., Parri, H.R. (2011) Non-neuronal, slow GABA signalling in the VB thalamus targets delta subunit containing GABA(A) receptors. Eur.J.Neurosci. 2011 Apr;33(8):1471-82. Parri, H.R. Hernandez, C.M., Dineley, K.T. (2011) Research Update: Alpha 7 nicotinic acetylcholine receptor mechanisms in Alzheimer's Disease. Biochem. Pharmacol. 2011; 82: 931-42. Hughes, S.W., Lorincz, M.L., Parri, H.R., Crunelli, V. (2011) Infraslow (<1Hz) oscillations in thalamic relay nuclei, basic mechanisms and significance to health and disease states. Prog Brain Res. 2011; 193C:145-162. Parri HR, Gould TM, Crunelli V. (2010) Sensory and cortical activation of distinct glial cell subtypes in the somatosensory thalamus of young rats. Eur J Neurosci. 2010 Jul;32(1):29-40.