Vernallis, Ann B - Aston University - School of Life & Health Sciences, Biology/Biosciences

个人简介

Summer student, Rocky Mountain Biological Laboratory, Colorado, USA, 1983 B.S., Biology (top 5%) Stanford University, Standford, California, USA. PhD., Neurobiology Department of Biology, University of California at San Diego, La Jolla, California, USA, 1992 Professional Certificate in Teaching and Learning Aston University Birmingham, United Kingdom - Accreditation as a Teacher in Higher Education awarded by Staff and Educational Development Association (SEDA), 2000 2014-date: Senior Lecturer in Cell Biology, Aston University 1998-2014: Lecturer in Cell Biology, Aston University 1996-98: Cancer Research Campaign, Post-doctoral Research Fellow, University of Birmingham 1993-95: American Cancer Society, Post-doctoral Fellow, University of Oxford

研究领域

My main interest is in cytokines and other mediators of inflammation. I collaborate with Prof Peter Lambert and others on the host response to bacteria infection and the therapeutic potential of tetracyclines to reduce inflammation.

近期论文

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Albert, H. B., Lambert, P., Rollason, J., Sorensen, J. S., Worthington, T., Pedersen, M. B., N?rgaard, H. S., Vernallis, A., Busch, F., Manniche, C. & Elliott, T. (2013). Does nuclear tissue infected with bacteria following disc herniations lead to Modic changes in the adjacent vertebrae? European Spine Journal. 22, 4, 690-696 Kolamunne, R. T., Dias, I. H. K., Vernallis, A. B., Grant, M. M. & Griffiths, H. R. (2013). Nrf2 activation supports cell survival during hypoxia and hypoxia/reoxygenation in cardiomyoblasts; the roles of reactive oxygen and nitrogen species. Redox Biology. 1, 1, 418-426 Rollason, J., McDowell, A., Albert, H. B., Barnard, E., Worthington, T., Hilton, A. C., Vernallis, A., Patrick, S., Elliott, T. & Lambert, P. (2013). Genotypic and antimicrobial characterisation of Propionibacterium acnes isolates from surgically excised lumbar disc herniations. BioMed Research International. 7 530382 Dunston CR, Griffiths HR, Lambert PA, Staddon S, Vernallis AB. (2011) Proteominc analysis of the anti-inflammatory action of minocycline. Proteomics. 11(1):42-51. Jazayeri JA, Upadhyay A, Vernallis AB, Carroll GJ. (2010) Targeting the glycoprotein 130 receptor subunit to control pain and inflammation. J Interferon Cytokine Research. 30(12):865-73. Jazayeri, J.A., Carroll, G.J., Vernallis, A.B. (2009) Interleukin-6 subfamily cytokines and rheumatoid arthritis: Role of antagonists. International Immunopharmacology. 10(1):1-8. Chobotova K, Vernallis, A.B., Majid F.A. (2009) Bromelain's activity and potential as an anti-cancer agent: Current evidence and perspectives. Cancer Letters. 290(2):148-56. Hill, EJ, Vernallis AB (2008) Polarized Secretion of Leukemia Inhibitory Factor, BMC Cell Biol. 2008 Sep 18;9:53. Watkin RW, Harper LV, Vernallis AB, Lang S, Lambert PA, Ranasinghe AM, Elliott TSJ (2007)Pro-inflammatory cytokines IL6, TNF-alpha, IL1 beta, procalcitonin, lipopotysaccharide binding protein and C-reactive protein in infective endocarditis Journal of Infection 55 (3) 220-225 Jones, K.J., Perris, A.D., Vernallis, A.B., Worthington, T., Lambert, P.A., and Elliott, T.S. (2005). Induction of inflammatory cytokines and nitric oxide in J774.2 cells and murine macrophages by lipoteichoic acid and related cell wall antigens from Staphylococcus epidermidis.Journal of Medical Microbiology. 54 (Pt 4), 315-321. Malaval, L., Liu, F., Vernallis, A.B., and Aubin, JE. (2005). GP130/OSMR is the only LIF/IL-6 family receptor complex to promote osteoblast differentiation of calvaria progenitors. Journal of Cellular Physiology 204(2):585-593. Vernallis, A.B. (2003). “Leukemia Inhibitory Factor (LIF)” in Encyclopedia of Hormones, Vol 2 pgs 578-586. Edited by Dr. H.L. Henry and Dr. A W Norman. Academic Press, San Diego. Monville, C., Fages, C., Feyens, A.-M., d'Hont, V., Guillet, C., Vernallis, A., Gascan, H., and Peschanski, M. (2002). Astroglial expression of the P-glycoprotein is controlled by intracellular CNTF. BMC Cell Biology. 3:20. Rowan, A.D., Koshy, P.J.T., Shingleton, W.D., Degnan, B.A., Heath, J.K., Vernallis, A.B., Spaull, J.R., Life, P.F., Hudson, K., and Cawston, T.E. (2001). Synergistic effects of glycoprotein 130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown. Arthritis & Rheumatism. 44, 1620-1632. Vernallis, A.B. (2001). “Receptor Antagonists of gp130 Signaling Cytokines” in Cytokine Inhibitors, edited by G. Ciliberto and R. Savino. Marcel Dekker, Inc., New York. 201-240. Aubert, J., Dessolin, S., Belmonte, N., Li, M., McKenzie, F.R., Staccini, L., Villageois, P., Barhanin, B., Vernallis, A., Smith, A.G., Ailhaud, G., and Dani, C. (1999). Leukemia Inhibitory Factor and Its Receptor Promote Adipocyte Differentiation via the Mitogen-activated Protein Kinase Cascade. The Journal of Biological Chemistry. 274, 24965-24972. Vernallis, A.B., Hudson, K.R., and Heath, J.K., (1997). An antagonist for the leukemia inhibitory factor receptor inhibits leukemia inhibitory factor, cardiotrophin-1, ciliary neurotrophic factor, and oncostatin M. The Journal of Biological Chemistry. 272, 26947-26952. Pitard, V., Taupin, J-L, Miossec, V., Blanchard, F., Cransac, M., Jollet, I., Vernallis, A., Hudson, K., Godard, A., Jacques, Y., and Moreau, J.F. (1997) Production and characterization of monoclonal antibodies against the leukemia inhibitory factor low affinity receptor, gp190. Journal of Immunological Methods. 205, 177-190. Neophytou, C., Vernallis, A.B., Smith, A. and Raff M.C. (1997). Muller-cell-derived leukaemia inhibitory factor arrests rod photoreceptor differentiation at a postmitotic pre-rod stage of development. Development. 124, 2345-2354. Thompson S.W.N., Vernallis, A.B., Heath, J.K., and Priestley, J.V. (1997). Leukaemia inhibitory factor is retrogradely transported by a distinct population of adult rat sensory neurons: co-localization with trkA and other neurochemical markers. European Journal of Neuroscience. 9, 1244-1251.