Hanson, Peter - Aston University - School of Life & Health Sciences, Pharmacy

个人简介

1977- Lecturer in Biochemistry, Aston University 1976-77 College Lecturer in Medical Biochemistry, Brasenose College, Oxford 1974-77 MRC Post Doctoral Research Assistant, University of Oxford 1971-74 PhD (MRC Scholarship) University of Oxford, Department of Biochemistry

研究领域

Applications of preparations of gastric and colonic epithelial cells grown on porous polycarbonate support membranes (Transwells) in biopharmaceutical screening Effects of endotoxin (lipopolysaccharide) on apoptosis and barrier function in gastric and colonic epithelial monolayers The pharmacology and biochemistry of signal transduction mechanisms in the gastrointestinal tract

近期论文

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Absorption and metabolism of chlorogenic acids in cultured gastric epithelial monolayers. Farrell, T. L. , Dew, T. P. , Poquet, L. , Hanson, P. & Williamson, G. Dec-2011 In : Drug metabolism and disposition. 39, 12, p. 2338-2346. Physicochemical characterisation, drug polymer dissolution and in vitro evaluation of phenacetin and phenylbutazone solid dispersions with polyethylene glycol 8000. Khan, S. , Batchelor, H. , Hanson, P. , Perrie, Y. & Mohammed, A-U-R. Oct-2011 In : Journal of pharmaceutical sciences. 100, 10, p. 4281-4294. Systems biology approach to study permeability of paracetamol and its solid dispersion. Khan, S. , Elshaer, A. , Rahman, A. S. , Hanson, P. , Perrie, Y. & Mohammed, A-U-R. Sep-2011 In : International journal of pharmaceutics. 417, 1-2, p. 272-279. Genomic evaluation during permeability of indomethacin and its solid dispersion. Khan, S. , ElShaer, A. , Rahman, A. S. , Hanson, P. , Perrie, Y. & Mohammed, A-U-R. Sep-2011 In : Journal of drug targeting. 19, 8, p. 615-623. Use of amino acids as counterions improves the solubility of the BCS II model drug, indomethacin. ElShaer, A. , Khan, S. , Perumal, D. , Hanson, P. & Mohammed, A-U-R. Jul-2011 In : Current drug delivery. 8, 4, p. 363-372. Paracellular permeability is increased by basal lipopolysaccharide in a primary culture of colonic epithelial cells; an effect prevented by an activator of Toll-like receptor-2. Hanson, P. J. , Moran, A. P. & Butler, K. Jun-2011 In : Innate immunity. 17, 3, p. 269-282. . High permeability of the anionic form restricts accumulation of indomethacin by cultured gastric surface epithelial cells exposed to low apical pH. Kavvada, K. M., Murray, J. G., Moore, V. A., Coombes, A. G. A. & Hanson. P. J. (2006) Eur. J. Pharmacol. 549, 41-49. Apoptosis induction in gastric mucous cells in vitro: lesser potency of Helicobacter pylori than Escherichia coli lipopolysaccharide, but positive interaction with ibuprofen. Durkin, E., Moran, A.P., & Hanson. P.J. (2006). Journal of Endotoxin Research. 12, 47-56.