Burton, Dominick - Aston University - School of Life & Health Sciences, Biology/Biosciences

个人简介

2015-Date: Marie Curie Research Fellow, Aston University, UK 2012-2015: Postdoctoral Research Fellow, Weizmann Institute of Science, Israel 2010-2012: Postdoctoral Associate, University of Miami, USA 2003-2008: PhD, University of Brighton, UK 2002-2003: MSc, Molecular Biology, Swansea University, UK 1999-2002: BSc, Genetics Hons, Queen Mary University of London, UK.

研究领域

My current research interests are focused on understanding how senescent cells and immune cells interact with each other to facilitate immune clearance of senescent cells. In particular, I am interested in determining whether immunosenescence contributes to the accumulation of senescent cells in aged and diseased tissues by failing to remove them.

近期论文

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Biran A, Perelmutter M, Gal H, Burton DG, Ovadya Y, Vadai E, Geiger T, Krizhanovsky V. (2015) Senescent cells communicate via intercellular protein transfer.Genes Dev. Apr 15;29(8):791-802. doi: 10.1101/gad.259341.115. Burton DG, Faragher RG. (2015) Cellular senescence: from growth arrest to immunogenic conversion. Age (Dordr). Apr;37(2):27. doi: 10.1007/s11357-015-9764-2. D.G.A.Burton and V.Krizhanovsky (2014) Physiological and Pathological consequences of cellular senescence.(2014) Cell Mol Life Sci. Nov;71(22):4373-86. doi: 10.1007/s00018-014-1691-3 Asmita Patel, Dominick GA Burton, Katherine Halvorsen, Wayne Balkan, Teresita Reiner, Carlos Perez-Stable, Alexander Cohen, Anisleidys Munoz, Maria G. Giribaldi, Samer Singh, David J. Robbins, Dao M. Nguyen, Priyamvada Rai (2014). MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways. Oncogene. 2015 May 14;34(20):2586-96. doi: 10.1038/onc.2014.195. Dominick GA Burton, Maria G. Giribaldi, Asmita Patel, Merce Jorda, Carlos Perez-Stable, Priyamvada Rai. (2013) Androgen Deprivation-Induced Senescence Promotes Outgrowth of Androgen-Refractory Prostate Cancer Cells.PLoS One. Jun 28;8(6):e68003. doi: 10.1371/journal.pone.0068003. Faragher RG, Burton DG, Majecha P, Fong NS, Davis T, Sheerin A, Ostler EL. Resveratrol, but not dihydroresveratrol, induces premature senescence in primary human fibroblasts. (2011) Age (Dordr). Dec;33(4):555-64. doi: 10.1007/s11357-010-9201-5. Rai P, Young JJ, Burton DG, Giribaldi MG, Onder TT, Weinberg RA. (2011) Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence. Oncogene. Mar 24;30(12):1489-96. doi: 10.1038/onc.2010.520 Burton DG, Matsubara H, Ikeda K. (2010) Pathophysiology of vascular calcification: Pivotal role of cellular senescence in vascular smooth muscle cells. Exp Gerontol. 2010 Nov;45(11):819-24. doi: 10.1016/j.exger.2010.07.005. D.G.A. Burton, P.J. Giles, A.N. Sheerin, K.Smith, E.L.Ostler, W.Rhys-Williams, D.Kipling, R.G. A. Faragher (2009) Microarray analysis of senescent vascular smooth muscle cells: Links to atherosclerosis and vascular calcification. Exp Gerontol. 2009 Oct;44(10):659-65. doi: 10.1016/j.exger.2009.07.004 D.G.A Burton (2009) Cellular senescence, ageing and disease.Age (Dordr). 2009 Mar;31(1):1-9. doi: 10.1007/s11357-008-9075-y. D.G.A. Burton, Angela N. Sheerin, Elizabeth L. Ostler, Kaye Smith, Peter J. Giles, Jill Lowe, William Rhys-Williams, David G. Kipling & Richard G.A. Faragher (2007) Cyclin D1 over-expression permits the reproducible detection of senescent human vascular smooth muscle cells. Ann N Y Acad Sci. 2007 Nov;1119:20-31. D.G.A.Burton, M.C.Allen, J.L.E.Bird, R.G.A.Faragher (2005). Bridging the gap: ageing, pharmacokinetics and pharmacodynamics. Journal of pharmacy and pharmacology, 57 (6) 671-679.