Bill, Roslyn - Aston University - School of Life & Health Sciences, Biology/Biosciences

个人简介

2016-date LHS Associate Dean Research 2012-date Professor of Biotechnology, Aston University 2010-2012 Director of Aston Research Centre for Healthy Ageing 2005-2012 Reader in Molecular Biosciences, Aston University 2002-2004 Innovation Fellow (40% at BPU: 60% at LHS), Aston University 2001-02 Assistant Professor, Chalmers University of Technology, G?teborg, Sweden Shareholder in the start-up company Gothia Yeast Solutions AB Co-founder and Manager of the Expression & Purification Laboratory of the SWEGENE Membrane Protein Centre 1998-01 Researcher, G?teborg University, G?teborg, Sweden (PI: Professor Stefan Hohmann)Member of EC-funded G?teborg Yeast Centre 1996-98 Fulbright Scholar, University of Michigan, USA (PI: Professor Gary Glick) 1994-96 Clinical Scientist, Department of Medical Genetics, Addenbrooke's NHS Trust, Cambridge, UK 1991-94 DPhil, Wellcome Trust Prize Student, University of Oxford (Supervisor: Professor Sabine Flitsch) 1990-91 Technical Assistant, Abel & Imray Chartered Patent Agents, UK 1986-90 BA (Hons), 1st class, Natural Science (Chemistry), University of Oxford (BA Grad. 1991 MA Grad. 1993)

研究领域

Membrane proteins play pivotal roles in all cellular functions. These include the transport of nutrients, the export of toxins and cell-cell interactions. They are also ubiquitous: ~30% of all proteins in all cells are membrane proteins. Consequently they are already key drug targets, with the majority of prescription pharmaceuticals on the market being targeted to this class of protein. Unfortunately, however, they are neither naturally abundant nor stable, which means that in the vast majority of cases extracting them from natural sources is not a viable option in order to study their structures, functions and biochemistry

近期论文

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Cartwright, SP, Mikaliunaite, L & Bill, RM 2016, 'Membrane protein production in the Yeast,S. cerevisiae' . in I Mus-Veteau (ed.),Heterologous expression of membrane proteins.Methods in Molecular Biology, vol. 1432, Springer, New York (US), pp. 23-35,10.1007/978-1-4939-3637-3_2 Hardy, D, Bill, RM, Jawhari, A & Rothnie, AJ 2016, 'Overcoming bottlenecks in the membrane protein structural biology pipeline' Biochemical Society Transactions, vol. 44, no. 3, pp. 838-844,10.1042/BST20160049 Wheatley, M, Charlton, J, Jamshad, M, Routledge, SJ, Bailey, S, La-Borde, PJ, Azam, MT, Logan, RT, Bill, RM, Dafforn, TR & Poyner, DR 2016, 'GPCR-styrene maleic acid lipid particles (GPCR-SMALPs): their nature and potential' Biochemical Society Transactions, vol. 44, no. 2, pp. 619-623,10.1042/BST20150284 Kitchen, P, Conner, MT, Bill, RM & Conner, AC 2016, 'Structural determinants of oligomerization of the aquaporin-4 channel' Journal of Biological Chemistry, vol. 291, no. 13, pp. 6858-6871,10.1074/jbc.M115.694729 Routledge, S, Mikaliunaite, L, Patel, A, Clare, M, Cartwright, SP, Bawa, Z, Wilks, MDB, Low, F, Hardy, D, Rothnie, AJ & Bill, RM 2016, 'The synthesis of recombinant membrane proteins in yeast for structural studies' Methods, vol. 95, pp. 26-37,10.1016/j.ymeth.2015.09.027 Kitchen, P, Day, RE, Salman, MM, Conner, MT, Bill, RM & Conner, AC 2015, 'Beyond water homeostasis: diverse functional roles of mammalian aquaporins' BBA - General Subjects, vol. 1850, no. 12, pp. 2410-2421,10.1016/j.bbagen.2015.08.023 Kitchen, P, ?berg, F, Sj?hamn, J, Hedfalk, K, Bill, RM, Conner, AC, Conner, MT & T?rnroth-Horsefield, S 2015, 'Plasma membrane abundance of human aquaporin 5 is dynamically regulated by multiple pathways' PLoS ONE, vol. 10, no. 11, e0143027,10.1371/journal.pone.0143027 Day, R, Kitchen, P, Salman, M, Bill, R, Conner, A & Conner, M 2015, 'Rapid tonicity induced re-localisation of endogenous aquaporin 4 in primary rat astrocytes - a therapeutic target for cytotoxic brain oedema?' GLIA, vol. 63, no. Suppl.S1, T13-01B, pp. E406-E407,10.1002/glia.22870 Kitchen, P, Day, RE, Taylor, LHJ, Salman, MM, Bill, RM, Conner, MT & Conner, AC 2015, 'Identification and molecular mechanisms of the rapid tonicity-induced relocalization of the aquaporin 4 channel' Journal of Biological Chemistry, vol. 290, pp. 16873-16881,10.1074/jbc.M115.646034 Booe, JM, Walker, CS, Barwell, J, Kuteyi, G, Simms, J, Jamaluddin, MA, Warner, ML, Bill, RM, Harris, PW, Brimble, MA, Poyner, DR, Hay, DL & Pioszak, AA 2015, 'Structural basis for receptor activity-modifying protein-dependent selective peptide recognition by a G protein-coupled receptor' Molecular Cell, vol. 58, no. 6, pp. 1040-1052,10.1016/j.molcel.2015.04.018 Berger, I & Bill, RM 2015, 'Editorial overview: new protein production tools for structural biology' Current Opinion in Structural Biology, vol. 32, pp. v–vii,10.1016/j.sbi.2015.05.006 Bill, RM & von der Haar, T 2015, 'Hijacked then lost in translation: the plight of the recombinant host cell in membrane protein structural biology projects' Current Opinion in Structural Biology, vol. 32, pp. 147-155,10.1016/j.sbi.2015.04.003 Prielhofer, R, Cartwright, S, Graf, A, Valli, M, Bill, R, Mattanovich, D & Gasser, B 2015, 'Pichia pastorisregulates its gene-specific response to different carbon sources at the transcriptional, rather than the translational, level' BMC Genomics, vol. 16, no. 1, 167,10.1186/s12864-015-1393-8 Jamshad, M, Charlton, J, Lin, Y-P, Routledge, SJ, Bawa, Z, Knowles, TJ, Overduin, M, Dekker, N, Dafforn, TR, Bill, RM, Poyner, DR & Wheatley, M 2015, 'G-protein-coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent' Bioscience Reports, vol. 35, no. 2, e00188,10.1042/BSR20140171 Bill, RM 2015, 'Recombinant protein subunit vaccine synthesis in microbes: a role for yeast?' Journal of Pharmacy and Pharmacology, vol. 67, no. 3, pp. 319-328,10.1111/jphp.12353 Bill, R 2015, ' Recombinant protein subunit vaccine synthesis in microbes: a role for yeast? ' Journal of pharmacy and pharmacology . Bawa, Z, Routledge, SJ, Jamshad, M, Clare, M, Sarkar, D, Dickerson, I, Ganzlin, M, Poyner, DR & Bill, RM 2014, 'Functional recombinant protein is present in the pre-induction phases ofPichia pastoriscultures when grown in bioreactors, but not shake-flasks' Microbial Cell Factories, vol. 13, no. 1, 127,10.1186/s12934-014-0127-y Day, RE, Kitchen, P, Owen, D, Bland, C, Marshall, L, Conner, AC, Bill, RM & Conner, MT 2014, 'Human aquaporins: regulators of transcellular water flow' BBA - General Subjects,10.1016/j.bbagen.2013.09.033 Bill, RM 2014, 'Playing catch-up withEscherichia coli: using yeast to increase success rates in recombinant protein production experiments' Frontiers in Microbiology, vol. 5, 85,10.3389/fmicb.2014.00085 Routledge, SJ, Poyner, DR & Bill, RM 2014, 'Antifoams: the overlooked additive?' Pharmaceutical Bioprocessing, vol. 2, no. 2, pp. 103-106,10.4155/pbp.14.17