个人简介

B.A., Universidad de Buenos Aires (1996) Ph.D., Boston University (2001) Post Doc., Columbia University (2001-2003)

研究领域

Physical Chemistry

The research in my group focuses mainly on two areas; the structure and dynamics of novel materials called room-temperature ionic liquids and the association of sugars and proteins. Modern ionic liquids are salts that are liquid at room temperature. We are interested in understanding their organizational patterns, the dynamics of solutes dissolved in them as well as electron transfer processes and other dynamical properties. We are also very interested in analyzing and predicting x-ray scattering experiments as these tell us about short and long range order in these complex systems. Carbohydrates are important recognition agents. We are currently interested in cyanovirin and its mutants. This protein binds carbohydrates on the surface of the HIV virus.

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Solvation of an Excess Electron in Pyrrolidinium Dicyanamide Based Ionic Liquids. Changhui Xu and Claudio J. Margulis. DOI: 10.1021/jp5108922. Published as ASAP, December 18,2014. J. Phys. Chem. B Bicontinuity and Multiple Length Scale Ordering in Triphilic Hydrogen-Bonding Ionic Liquids. Jeevapani J. Hettige, Juan Carlos Araque, Claudio. J. Margulis. J. Phys. Chem. B, 2014, 118 (44), pp 12706–12716 (JOURNAL COVER) Communication: Anomalous Temperature Dependence of the Intermediate Range Order in Phosphonium Ionic Liquids. Jeevapani Hettige, Hemant K. Kashyap, Claudio Margulis J. Chem. Phys., 140, 111102, 2014 The Role of Glu41 in the Binding of Dimannose to P51G-m4-CVN. Sai Kumar Ramadugu, Zhen Li, Hemant Kashyap, Claudio Margulis. Biochemistry, 53 (9), pp 1477–1484, 2014 DOI: 10.1021/bi4014159 Dynamics of Excess Electronic Charge in Aliphatic Ionic Liquids Containing the Bis(trifluoromethylsulfonyl)amide Anion. Changhui Xu, Aleksander Durumeric, Hemant K. Kashyap, Jorge J. Kohanoff, and Claudio Javier Margulis. J. Am. Chem. Soc., 135 (46), pp 17528–17536, 2013 DOI: 10.1021/ja409338z Structure of 1-Alkyl-1-methylpyrrolidinium Bis(trifluoromethylsulfonyl)amide Ionic Liquids with Linear, Branched and Cyclic Alkyl Groups. Kashyap, Hemant; Santos, Cherry; Murthy, N. Sanjeeva; Hettige, Jeevapani; Ramati, Sharon; Kerr, Kijana; Gwon, JinHee; Gohdo, Masao; Lall-Ramnarine, Sharon; Wishart, James; Margulis, Claudio; Castner, Edward. J. Phys. Chem. B, 117 (49), pp 15328–15337, 2013 DOI: 10.1021/jp403518j How does the Ionic Liquid Organizational Landscape Change when Nonpolar Cationic Alkyl Groups Are Replaced by Polar Isoelectronic Diethers? Hemant Kashyap, Cherry Santos, Ryan Daly, Jeevapani Hettige, N. Murthy, Hideaki Shirota, Edward Castner Jr., Claudio J. Margulis. J. Phys. Chem. B, 117 (4), pp 1130–1135, 2013 DOI: 10.1021/jp311032p Anions, the Reporters of Structure in Ionic Liquids. Jeevapani J. Hettige, Hemant K. Kashyap, Harsha V. R. Annapureddy and Claudio J. Margulis. J. Phys. Chem. Lett., 4 (1), pp 105–110, 2013 DOI: 10.1021/jz301866f Theoretical Deconstruction of the X-ray Structure Function Exposes Polarity Alternations in Room Temperature Ionic Liquids. H. K. Kashyap and C. J. Margulis. For the 222nd ECS Meeting in Honolulu, Hawaii. ECS Transactions, 50 (11), 301–307, 2012. doi:10.1149/05011.0301ecst SAXS Anti-Peaks Reveal the Length-Scales of Dual Positive/Negative and Polar/Apolar Ordering in Room-Temperature Ionic Liquids. Hemant K. Kashyap, Jeevapani J. Hettige, Harsha V. R. Annapureddy and Claudio J. Margulis. ChemComm (Special Issue on Ionic Liquids), 48, 5103-5105, 2012 DOI: 10.1039/C2CC30609C Temperature-dependent structure of ionic liquids : X-ray scattering and simulations. Hemant K. Kashyap, Cherry S. Santos, Harsha V. R. Annapureddy, N. Sanjeeva Murthy, Claudio J. Margulis and Edward W. Castner, Jr. Faraday Discussions, 154, 133, 2012 (Advance Article, Accepted 15 Jun 2011, published on web Jul 19, 2011) DOI: 10.1039/C1FD00059D Dry Excess Electrons in Room-Temperature Ionic Liquids. Claudio Javier Margulis , Harsha V. R. Annapureddy , Pablo Martin De Biase , David Coker , Jorge Kohanoff, and Mario G. Del Popolo, Journal of the American Chemical Society, 2011, 133 (50), 20186–20193 DOI: 10.1021/ja203412v Searching and Optimizing Structure Ensembles for Complex Flexible Sugars. Junchao Xia, Claudio J. Margulis, and David A. Case. Journal of the American Chemical Society (Communication), 2011, 133 (39), 15252–15255 DOI: 10.1021/ja205251j How is Charge Transport Different in Ionic Liquids and Electrolyte Solutions? Hemant K. Kashyap, Harsha V. R. Annapureddy, Fernando O. Raineri and Claudio J. Margulis. J. Phys. Chem. B, 2011, 115 (45), 13212–13221 DOI: 10.1021/jp204182c Ionic Liquids: Structure and Photochemical Reactions. Edward W. Castner Jr., Claudio J. Margulis, Mark Maroncelli and James F. Wishart. Annual Review of Physical Chemistry, 62, 2011. First Posted Online Nov 22, 2010 DOI: 10.1146/annurev-physchem-032210-103421 Temperature-dependent structure of methyltributylammonium bis(trifuoromethylsulfonyl)amide: X-ray scattering and simulations. Cherry S. Santos, Harsha V. R. Annapureddy, N. Sanjeeva Murthy, Hemant K. Kashyap, Edward W. Castner Jr. and Claudio J. Margulis. J. Chem. Phys. 134, 064501, 2011 (JOURNAL COVER) http://dx.doi.org/10.1063/1.3526958 What is the Origin of the Prepeak in the X-Ray Scattering of Imidazolium Based Room Temperature Ionic Liquids? Harsha V. R. Annapureddy, Hemant K. Kashyap, Pablo M. De Biase, and Claudio J. Margulis. J. Phys. Chem. B, 114 (50), 16838–16846, 2010 (JOURNAL COVER) DOI: 10.1021/jp108545z In Silico Prediction of the 3D Structure of Trimeric Asialoglycoprotein Receptor Bound to Triantennary Oligosaccharide. Sai Kumar Ramadugu, Ying-Hua Chung, Ernesto J. Fuentes, Kevin G. Rice and Claudio J. Margulis. Journal of the American Chemical Society, 132 (26), 9087–9095, 2010 DOI: 10.1021/ja1021766 Measuring the Magnitude of Internal Motion in a Complex Hexasaccharide. Soumya Ganguly, Junchao Xia, Claudio Margulis, Liz Stanwyck and C. Allen Bush. Biopolymers, 95, 1, 2010 DOI: 10.1002/bip.21532 Computational Study of the Conformational Structures of Saccharides in Solution Based on J couplings and the "Fast Sugar Structure Prediction Software". Junchao Xia and Claudio J. Margulis. Biomacromolecules, 10, 11, 3081-3088, 2009. DOI: 10.1021/bm900756q When sugars get wet. A comprehensive study of the behavior of water on the surface of oligosaccharides. Sai Kumar Ramadugu, Ying-Hua Chung and Claudio J. Margulis. J. Phys. Chem. B, 113 (31), 11003–11015, 2009 DOI: 10.1021/jp904981v Controlling the outcome of Electron Transfer Reactions in Ionic Liquids. Harsha V. R. Annapureddy and Claudio J. Margulis. J. Phys. Chem. B, 113, 35, 12005-12012, 2009 DOI: 10.1021/jp905144n Rationalization of the Difference in Lifetime of Two Covalent Sialosyl-Enzyme Intermediates of Trypanosoma rangeli Sialidase. Laura L. Parker, Ying-Hua Chung, Claudio J. Margulis and Jan H. Jensen. J. Phys. Chem. B (Letter), 112, 45, 14093-14095, 2008 DOI: 10.1021/jp804314x