Smith, Nicole - University of Western Australia

研究领域

>Secondary degeneration of intact tissue after traumatic central nervous system (CNS) injury is a major problem with no current therapies to prevent long-term functional decline. Inflammation, including the activation of resident microglial cells, plays an important role in these secondary changes. This multidisciplinary project aims to unravel the relationship between neuroinflammation and remote Blood Brain Barrier breakdown following neurotrauma and integrates pioneering nanoparticle technology to enable simultaneous delivery of therapeutics and imaging agents to halt or limit inflammation and remote BBB breakdown. >Targeting four-stranded DNA conformations to enable axonal regeneration following neurotrauma. In response to severe tissue damage or inflammation after severe trauma, reactive astrogliosis can lead to glial scarring. CNS scars consist of two distinct layers, fibrotic and glial. The glial scar forms the boundary between the fibrotic scar and the normal parenchymal tissues. Reactive astrocytes display increased expression of extracellular matrix components (ECM), including chondroitin sulfate proteoglycans (CSPGs), dramatic up-regulation of cytoskeletal proteins (Glial Fibrillary Acidic Protein (GFAP) vimentin and nestin) and increased expression of transcriptional regulators. As CSPGs have been implicated as barriers to CNS axon extension and are extremely inhibitory to axon outgrowth, the glial scar presents an obstacle for axonal regeneration. We are studying the implications of G-quadruplex DNA secondary structures in astrogliosis. It is well known that G4-DNA are implicated in transcriptional regulation. We are developing techniques to regulate formation of these structures in specific stress-induced genes in order to inhibit astrocyte activation and promote a regenerative environment >Targeting four-stranded DNA conformations to modulate gene expression in cancer and fibrosis.

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

20. V Agarwal, D Ho, D Ho, Y Galabura, F. M. D. Yasin, P Gong, W Ye, R Singh, A Munshi, M Saunders, R. C. Woodward, T St. Pierre, F. M. Wood, M. Fear, D. Lorenser, D. D. Sampson, B. Zdyrko, I. Luzinov, N. M. Smith and K. S. Iyer A Functional Reactive Polymer Electrospun Matrix ACS Applied Materials and Interface (2016), 8, 4934-4939 19 R. Singh, M. Norret, M. J. House, Y. Galabura, M. Bradshaw, D. Ho, R. C. Woodward, T. St. Pierre, I. Luzinov, N. M. Smith, L. Y. Lim, K. S. Iyer Dose Dependent Therapeutic Distinction between Active and Passive Targeting Revealed Using Transferrin Coated PGMA Nanoparticles Small (2016), 12, 351-9 18 Vipul Agarwal, Priyanka Toshniwal, Natalie E. Smith, Nicole M. Smith, Binbin Li, Tristan D. Clemons, Lindsay T. Byrne, Foteini Kakulas, Fiona M. Wood, Mark Fear, Ben Corry and K. Swaminathan Iyer, "Enhancing the Efficacy of Cation-Independent Mannose 6- Phosphate Receptor Inhibitors by Intracellular Delivery" Chem. Comm., 2015, DOI: 10.1039/C5CC06826F 17 I Lozić, RV Hartz, CA Bartlett, JA Shaw, M Archer, PSR Naidu, NM Smith, SA Dunlop, K Swaminathan Iyer, MR Kilburn, M Fitzgerald, "Enabling Dual Cellular Destinations of Polymeric Nanoparticles for Treatment Following Partial Injury to the Central Nervous System" Biomaterials, 2015, doi: 10.1016/j.biomaterials.2015.10.001 16. Ka-Heng Loh, Nicole M. Smith, Hideki Onagi, Stephen F. Lincoln, Christopher J. Easton, "A Cyclodextrin-Based Photoresponsive Molecular Gate that Functions Independently of Either Solvent or Potentially Competitive Guests” Chem. Asian J., 2015, DOI: 10.1002/asia.201500696. 15. N. K. Tangudu, V. K. Verma, T. D. Clemons, S. S. Beevi, T. Hay, G. Mahidhara, M. Raja, R. Nair, L. Alexander, A. Patel, J. Jose, N. M. Smith, B. Zdyrko, A. Bourdoncle, I. Luzinov, S. Iyer, A. R. Clarke, L. D. Kumar, "RNA Interference using c-Myc-Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models” Mol Cancer Ther., 2015, DOI: 10.1158/1535- 7163.MCT-14-0970. 14. Ho, Dominic; Zou, Jianli; Chen, Xianjue; Munshi, Alaa; Smith, Nicole M.; Agarwal, Vipul; Hodgetts, Stuart; Plant, Giles; Bakker, Anthony; Harvey, Alan; Luzinov, Igor; Iyer, K, “Hierarchical patterning of multifunctional conducting polymer nanoparticles as a bionic platform for topographic contact guidance” ACS Nano., 2015, 9(2), 1767-1774. 13. Naviin Hardy, Helena Viola, Vicky PA Johnstone, Tristan D Clemons, Henrietta Cserne Szappanos, Ruhani Singh, Nicole M Smith, K Swaminathan Iyer, Livia C Hool, "Nanoparticle-Mediated Dual Delivery of an Antioxidant and a Peptide against the L-type Ca2+ Channel Enables Reduction of Cardiac Ischemia-Reperfusion Injury" ACS Nano., 2015, 9(1), 279-289. 12. Gully, B.S., Shah, K.R., Lee, M., Shearston, K., Smith, N.M., Sadowska, A., Blythe, A.J., Bernath-Levin, K., Stanley, W.A., Small, I.D. “The design and structural characterization of a synthetic pentatricopeptide repeat protein” Acta Cryst. Sect. D., 2015, 71, 196-208. 11. Xianjue Chen, Nicole M. Smith, K. Swaminathan Iyer, Colin L. Raston, "Controlling nanomaterial synthesis, chemical reactions and self assembly in dynamic thin films" Chem. Soc. Rev., 2014,43, 1387-1399. 10. Nicole M. Smith, K. Swaminathan Iyer, Ben Corry, "The Confined Space Inside Carbon Nanotubes can Dictate the Stereo- and Regioselectivity of Diels-Alder reactions" Phys. Chem. Chem. Phys., 2014, 16(15), 6986-6989. 9. Jeremiah Toster, Qin Lin Zhou, Nicole M. Smith, K. Swaminathan Iyer, Federico Rosei, Colin L. Raston, "In situ coating of diatom frustules with silver nanoparticles" Green Chem., 2013, 15, 2060-2063. 8. Donna Savigni, Ryan L O'Hare Doig, Charis R Szymanski, Carole A Bartlett, Ivan Lozic, Nicole Smith, Melinda Fitzgerald, "Three Ca2+ channel inhibitors in combination reduce chronic secondary degeneration following neurotrauma" Neuropharmacology, 2013, 75C, 380-390 7. Nicole M. Smith, Samir Amrane, Frédéric Rosu, Valérie Gabelica, Jean-Louis Mergny, "Mercury-Thymine interaction with a chair type G-quadruplex architecture" Chem. Commun., 2012, 48, 11464-11466. 6. Ben Corry and Nicole M. Smith, "The role of thermodynamics and kinetics in ligand binding to G-quadruplex DNA" Chem. Commun., 2012, vol. 48, pp. 8958-8960. 5. N M Smith, Gaëlle Labrunie, Ben Corry, Phong Lan Thao Tran, Marck Norret, Mojgan Djavaheri-Mergny, Colin L Raston, Jean-Louis Mergny, "Unraveling the relationship between structure and stabilization of triarylpyridines as G-quadruplex binding ligands" Org Biomol Chem., 2011, vol. 9, pp. 6154-6162. 4. Loic Stefan, Aurore Guédin, Samir Amrane, Nicole Smith, Franck Denat, Jean-Louis Mergny, David Monchaud, "DOTASQ as a prototype of nature-inspired G-quadruplex ligand" Chem. Commun., 2011, 47, 4992-4994. 3. N M Smith, B Corry, K Swaminathan Iyer, M Norret, C L Raston, "A microfluidic platform to synthesise a G-quadruplex binding ligand" Lab Chip, 2009, 9, 2021-2025. 2. Nicole Maria Smith, Pengkai Soh, Nithiananthan Asokananthan, Marck Norret, Geoffrey A. Stewart, Colin Llewellyn Raston, "Immunomodulatory effects of functionalised chalcones on pro-inflammatory cytokine release from lung epithelial cells" New J. Chem.,2009, 33, 1793-1980. 1. Nicole M. Smith, Colin L. Raston, Christopher B. Smith, Alexandre N. Sobolev, "PEG mediated synthesis of amino-functionalised 2,4,6-triarylpyridines" Green Chem., 2007, 9, 1185 - 1190.