Berners-Price, Sue - University of Western Australia - School of Chemistry and Biochemistry

研究领域

Professor Sue Berners-Price was appointed to the newly established Chair in Biological Chemistry at UWA in 2001. Her teaching and research interests are in the field of Bioinorganic Chemistry and more specifically in the field of Medicinal Inorganic Chemistry. Research at the interface between inorganic chemistry, biology and medicine is providing exciting new insight into biological processes as well as novel ideas for the design of therapeutic agents involving both novel targets and novel mechanisms. Our research is directed towards the design and mechanism of action of metal-based anticancer agents. All projects involve strong interdisciplinary and some international collaboration.

近期论文

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P. J. Barnard, L. E. Wedlock, M. V. Baker, S. J. Berners-Price, D. A. Joyce, B. W. Skelton, J. H. Steer. Luminescence Studies of the Intracellular Distribution of a Dinuclear Gold(I) N-Heterocyclic Carbene Complex. Angew. Chem., Int. Ed. 45, 5966-5970 (2006). S. J. Berners-Price, L. Ronconi, P. J. Sadler. Insights into the mechanism of action of platinum anticancer drugs from multinuclear NMR spectroscopy. Prog. Nucl. Magn. Reson. Spectrosc. 49, 65-98 (2006). M. V. Baker, P. J. Barnard, S. J. Berners-Price, S. K. Brayshaw, J. L. Hickey, B. W. Skelton, A. H. White. Cationic, linear Au(I) N-heterocyclic carbene complexes: synthesis, structure and anti-mitochondrial activity. Dalton Trans. 3708-3715 (2006). M. V. Baker, P. J. Barnard, S. J. Berners-Price, S. K. Brayshaw, J. L. Hickey, B. W. Skelton, A. H. White. Synthesis and structural characterization of linear Au(I) N-heterocyclic carbene complexes: New analogues of the Au(I) phosphine drug Auranofin. J. Organomet. Chem. 690, 5625-5635 (2005). J. Zhang, D. S. Thomas, M. S. Davies, S. J. Berners-Price, N. Farrell. Effects of geometric isomerism in dinuclear platinum antitumor complexes on aquation reactions in the presence of perchlorate, acetate and phosphate. J. Biol. Inorg. Chem. 10, 652-666 (2005). S. J. Berners-Price, R. J. Bowen, M. A. Fernandes, M. Layh, W. J. Lesueur, S. Mahepal, M. M. Mtotywa, R. E. Sue, C. E. J. van Rensburg. Gold(I) and silver(I) complexes of 2,3-bis(diphenylphosphino)maleic acid: Structural studies and antitumour activity. Inorg. Chim. Acta 358, 4237-4246 (2005). P. J. Barnard, M. V. Baker, S. J. Berners-Price, D. A. Day. Mitochondrial permeability transition induced by dinuclear gold(I)-carbene complexes: potential new antimitochondrial antitumour agents. J. Inorg. Biochem. 98, 1642-1647 (2004). P. J. Barnard, M. V. Baker, S. J. Berners-Price, B. W. Skelton, A. H. White. Dinuclear gold(I) complexes of bridging bidentate carbene ligands: synthesis, structure and spectroscopic characterisation. Dalton Trans. 1038-1047 (2004). S. J. Berners-Price. Targeting the mitochondrial cell death pathway with gold complexes. Chem. in Aus. 71, 10-12 (2004). A. Hegmans, S. J. Berners-Price, M. S. Davies, D. S. Thomas, A. S. Humphreys, N. Farrell. Long Range 1,4 and 1,6-Interstrand Cross-Links Formed by a Trinuclear Platinum Complex. Minor Groove Preassociation Affects Kinetics and Mechanism of Cross-Link Formation as Well as Adduct Structure. J. Am. Chem. Soc. 126, 2166-2180 (2004). M. S. Davies, S. J. Berners-Price, J. W. Cox, N. Farrell. The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug. Chem. Commun. 122-123 (2003). S. J. Berners-Price, M. S. Davies, J. W. Cox, D. S. Thomas, N. Farrell. Competitive reactions of interstrand and intrastrand DNA-Pt adducts: A dinuclear-platinum complex preferentially forms a 1,4-interstrand cross-link rather than a 1,2 intrastrand cross-link on binding to a GG 14-mer duplex. Chem. Eur. J. 9, 713-725 (2003). M. J. McKeage, L. Maharaj, S. J. Berners-Price. Mechanisms of cytotoxicity and antitumor activity of gold(I) phosphine complexes: the possible role of mitochondria. Coord. Chem. Rev. 232, 127-135 (2002). M. S. Davies, D. S. Thomas, A. Hegmans, S. J. Berners-Price, N. Farrell. Kinetic and Equilibria Studies of the Aquation of the Trinuclear Platinum Phase II Anticancer Agent [{trans-PtCl(NH3)2}2{μ-trans-Pt(NH3)2(NH2(CH2)6NH2)2}]4+ (BBR3464). Inorg. Chem. 41, 1101-1109 (2002). J. W. Cox, S. J. Berners-Price, M. S. Davies, Y. Qu, N. Farrell. Kinetic analysis of the stepwise formation of a long-range DNA interstrand cross-link by a dinuclear platinum antitumor complex: evidence for aquated intermediates and formation of both Kinetically and thermodynamically controlled conformers. J. Am. Chem. Soc. 123, 1316-1326 (2001). M. J. McKeage, S. J. Berners-Price, P. Galettis, R. J. Bowen, W. Brouwer, L. Ding, L. Zhuang, B. C. Baguley. Role of lipophilicity in determining cellular uptake and antitumour activity of gold phosphine complexes. Cancer Chemother. Pharmacol. 46, 343-350 (2000). M. S. Davies, S. J. Berners-Price, T. W. Hambley. Slowing of Cisplatin Aquation in the Presence of DNA but Not in the Presence of Phosphate: Improved Understanding of Sequence Selectivity and the Roles of Monoaquated and Diaquated Species in the Binding of Cisplatin to DNA. Inorg. Chem. 39, 5603-5613 (2000). Y. Chen, J. A. Parkinson, P. Del Socorro Murdoch, Z. Guo, S. J. Berners-Price, T. Brown, P. J. Sadler. Sequence-dependent bending of DNA induced by cisplatin: NMR structures of an AT-rich 14-mer duplex. Chem. Eur. J. 6, 3636-3644 (2000). M. S. Davies, S. J. Berners-Price, T. W. Hambley. Rates of platination of -AG- and -GA- containing double-stranded oligonucleotides: effect of chloride concentration. J. Inorg. Biochem. 79, 167-172 (2000). M. S. Davies, J. W. Cox, S. J. Berners-Price, W. Barklage, Y. Qu, N. Farrell. Equilibrium and Kinetic Studies of the Aquation of the Dinuclear Platinum Complex [{trans-PtCl(NH3)2}2(μ-NH2(CH2)6NH2)]2+: pKa Determinations of Aqua Ligands via [1H,15N] NMR Spectroscopy. Inorg. Chem. 39, 1710-1715 (2000). Selected Publications prior to 2000 M. S. Davies, S. J. Berners-Price, T. W. Hambley. Rates of Platination of AG and GA Containing Double-Stranded Oligonucleotides: Insights into Why Cisplatin Binds to GG and AG but Not GA Sequences in DNA. J. Am. Chem. Soc. 120, 11380-11390 (1998).