个人简介

NIH Ruth L. Kirschstein NRSA Postdoctoral Fellow 2014 - 2015 American Chemical Society Division of Medicinal Chemistry Predoctoral Fellow 2010 – 2011 A. Lynn Anderson Award for Excellence in Graduate Research 2010 UW-Parkside Outstanding Graduate 2007

研究领域

Organic Chemistry/Inorganic & Organometallic Chemistry/Environmental & Green Chemistry/Polymer Chemistry/Chemical Biology

The fundamental goal of the Topczewski lab is to make chemical synthesis sustainable. Presently, consumer products, which range from plastic bottles to modern pharmaceuticals, are almost exclusively derived from the arduous refining of petroleum. This is inherently unsustainable and two approaches exist to bridge the sustainability gap: 1) to develop more efficient ways to use dwindling fossil fuels and 2) to develop methods to sustainably use biomass as a feedstock for chemical synthesis. For either of these approaches to make an impact, one must qualify what is meant by "more efficient" and " sustainable." This necessitates the use of quantitative metrics to be used as a guiding principle. To these ends, a number of projects are underway including: 1) direct catalytic approached to high value products such as chiral amines and carbocycles, designing catalytic cycles to enable the conversion of renewable feedstocks to monomers, and the utilization and development of metrics to evaluate synthetic methods.

近期论文

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Topczewski, J. J.; Sanford, M. S. “Carbon-Hydrogen (C-H) Bond Activation at Pd(IV): A Frontier in Catalysis” Chem. Sci. 2015, 6, 70. (Invited Review) (DOI: 10.1039/c4sc02591a) Brooks, A. F.; Topczewski, J. J.; Ichiishi, N.; Sanford, M. S.; Scott, P. J. H. “Late-stage [18F]Fluorination: New Solutions to Old Problems” Chem. Sci. 2014, 5, 4545. (DOI: 10.1039/C4SC02099E) Ichiishi, N.; Brooks, A. F.; Topczewski, J. J.; Rodnick, M. E.; Sanford, M. S.; Scott, P. J. H. “Copper-Catalyzed [18F]Fluorination of (Mesityl)(aryl)iodonium Salts” Org. Lett. 2014, 16, 3224. (DOI: 10.1021/ol501243g) Scott, P. J. H.; Sanford, M. S.; Ichiishi, N.; Brooks, A. F.; Rodnick, M. E. and Topczewski, J. J. "Copper Catalyzed [18F]Fluorination of Iodonium Salts" U. S. Patent Application Serial Number 61/978,646, filed 11 April 2014. Quinn, D. M. and Topczewski, J. J. "Compounds and Methods to Treat Organophosphorus Poisoning" U. S. Patent Application Number 14163859, filed 24 January 2014. Topczewski, J. J.; Lodge, A. M.; Yasapala, S. N.; Payne, M. K.; Keshavarzi, P. M.; Quinn, D. M. “Reversible Inhibition of Human Acetylcholinesterase by Methoxypyridinium Species” Bioorg. Med. Chem. Lett. 2013, 23, 5786. (DOI:10.1016/j.bmcl.2013.09.008) Kodet, J. G.; Topczewski, J. J.; Gardner, K. D.; Wiemer, D. F. “Electrophilic Prenylation via Cascade Cyclization” Tetrahedron 2013, 44, 9212. (DOI: 10.1016/j.tet.2013.08.056) Topczewski, J. J.; Quinn, D. M. “Kinetic Assessment of N-Methyl-2-Methoxypyridinium Species as Phosphonate Anion Methylating Agents” Org. Lett. 2013, 15, 1084. (DOI: 10.1021/ol400054m) Topczewski, J. J.; Tewson, T. J.; Nguyen, H. M. “Iridium-Catalyzed Allylic Fluorination of Trichloroacetimidates” J. Am. Chem. Soc. 2011, 133, 19318. (DOI: 10.1021/ja2087213) Topczewski, J. J. “Cascade Cyclizations and the Schweinfurthins” Ph.D. Thesis, University of Iowa, Iowa City, IA, 2011. Topczewski, J. J.; Callahan, M. P.; Kodet, J. G.; Inbarasu, J. D.; Mente, N. R.; Beutler, J. A.; Wiemer, D. F. “Relevance of the C-5 Position to Schweinfurthin Induced Cytotoxicity” Bioorg. Med. Chem. 2011, 19, 7570. (DOI: 10.1016/j.bmc.2011.10.034) Topczewski, J. J.; Wiemer, D. F. “First Total Synthesis of (+)-Vedelianin, a Potent Anti-proliferative Agent” Tetrahedron Lett. 2011, 52, 1628. (DOI:10.1016/j.tetlet.2011.01.137) Topczewski, J. J.; Kodet, J. G.; Wiemer, D. F. “Exploration of Cascade Cyclizations Terminated by Tandem Aromatic Substitution: Total Synthesis of (+)-Schweinfurthin A” J. Org. Chem. 2011, 76, 909. (DOI: 10.1021/jo1022102) Topczewski, J. J.; Kuder, C. H.; Neighbors, J. D.; Hohl, R. J.; Wiemer, D. F. “Fluorescent Schweinfurthin B and F Analogs with Anti-proliferative Activity” Bioorg. Med. Chem. 2010, 18, 6734. (DOI: 10.1016/j.bmc.2010.07.056) Topczewski, J. J.; Callahan, M. P.; Neighbors, J. D.; Wiemer, D. F. “A Tandem Cascade Cyclization-Electrophilic Aromatic Substitution: Application in the Total Synthesis of (+)-Angelichalcone” J. Am. Chem. Soc. 2009, 131, 14630. (DOI: 10.1021/ja906468v) Topczewski, J. J.; Neighbors, J. D.; Wiemer, D. F. “Total Synthesis of (+)-Schweinfurthins B and E” J. Org. Chem. 2009, 74, 6965. (DOI: 10.1021/jo901161m) Neighbors, J. D.; Topczewski, J. J.; Swenson, D. C.; Wiemer D. F. “Synthesis of the Cis-Fused Hexahydroxanthene System via Cationic Cascade Cyclization” Tetrahedron Lett. 2009, 50, 3881. (doi:10.1016/j.tetlet.2009.04.052)