于凤刚 - 济南大学 - 前沿交叉科学研究院

个人简介

于凤刚，博士，教授。于中国预防医学科学院传染病预防控制所获博士学位，加拿大多伦多大学博士后。2020年2月入职银丰生物集团，任生科院副院长，同时被聘为济南大学教授。另外还涉及EB病毒感染和鼻咽癌发病机制的研究。主持课题 1. Prospective isolation of cancer stem cells (CSCs) from nasopharyngeal cancer (NPC) primary tumor biopsies. NMRC central grant/NCIS Pilot grant. S$30,000 (PI). 2. Integrated analysis of somatic mutations and genomic aberrations in nasopharyngeal carcinoma (NPC). Terry Fox Foundation Grant. S$140,000 (Co-Investigator) 3. Genetic Polymorphisms and the Risk of Cisplatin-induced Ototoxicity in Asian Children. National University Hospital, University Children's Medical Institute (UCMI) grant. S$25,000. (Collaborator). 4. Intracellular redox milieu as a potential therapeutic target in NPC Cancer Stem Cells. National University Cancer Institute (NCIS) Centre Grant-Pilot Grant.S$30,000 (Co-Investigator) 5. Establishment of primary human nasal epithelial stem/progenitor cells in an air-liquid interface culture model and identification of their roles in infectious and allergic disease of the upper airway. A*STAR - SIgN 10-028. S$363,000(Co-Investigator) 6. TLR-3 ligand as an immune adjuvant in cetuximab based therapy in Head and Neck Cancer. NMRC/RIG grant. S$200,000. (Co-PI) 7. CD21-Mediated Entry and Stable Infection by Epstein - Barr virus in NPC and normal nasopharyngeal epithelial cells. NCIS- YONG SIEW YOON RESEARCH GRANT. S$200,000. (Co-PI) 8. Gene and MiRNA expression analysis of cancer-associated fibroblasts in nasopharyngeal carcinoma. NUHS Clinician Research Grant FY2013. $90,000. (Co-Investigator) 9. Nasal Pharyngeal Cancer: Team approach to cure. S$969,000 (Collaborator) 10. Ex vivo culture and molecular characterization of circulating NPC tumor cells potentially for individualized drug testing. NCIS Centre Grant FY2013-2016, Seed Funding Program. S$100,000 (PI). 11. The development of an orthotopic model of metastatic nasopharyngeal carcinoma using patient circulating tumor cells: implications for novel therapeutics. S$100,000. NUHS BENCH-TO-BEDSIDE (B2B) 2016. Lead PI 获奖 Winner of 2014 Yamagiwa-Yoshida Memorial International Cancer Study Fellowship/Union for International Cancer Control (UICC)

研究领域

主要从事神经干细胞，iPS细胞，呼吸道上皮干细胞的增殖、诱导分化、信号传导以及其在临床前疾病模型中的再生与修复研究。

近期论文

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1. Fenggang Yu*(corresponding author), Yanan Lu, Yingying Li, et al.Epstein-Barr virus infection of pseudostratified nasopharyngeal epithelium disrupts epithelial integrity. Cancers (in press). 2. Yu F*(corresponding author), Jia R, Tang Y, Liu J, Wei B. SARS-CoV-2 infection and stem cells: Interaction and intervention. Stem Cell Res. 2020. PMID: 32570174 Free PMC article. Review. 3. Fenggang Yu*(corresponding author), Nicholas L. Syn, Yanan Lu, et al. Characterization and establishment of a novel EBV strain simultaneously associated with nasopharyngeal carcinoma and B-cell lymphoma. bioRxiv 2020.03.26.009894; doi: https://doi.org/10.1101/2020.03.26.009894 4. Fenggang Yu*(corresponding author), Yanan Lu, Joshua K Taya, Hironori Yoshiyama, Kwok Seng Loh. Establishment of EBV-latency in nasopharyngeal tumor epithelial cells by in-vivo cell-mediated transfer infection. Otorhinolaryngol Head Neck Surg, Vol 3(3)2-7, 2018. 5. Lingzhi Wang; Nicholas Syn,Vinod Subhash, Yijia Any,Thuya Lwin, Esther Cheow, Liren Kong, Fenggan Yu, Praveen Peethala, Andrea Wong, Hirpara Laljibhai, Pei S Ong, Paul Ho, Gautam Sethi, Wei P Yong, Boon C Goh. Pan-HDAC inhibition by panobinostat mediates chemosensitization to carboplatin in non-small cell lung cancer via attenuation of EGFR signaling. Cancer Lett. 2018 Jan 4;417:152-160. 6. Fenggang Yu*(corresponding author), Yanan Lu, Fredrik Petersson, De-Yun Wang, Kwok Seng Loh. Presence of lytic Epstein-Barr virus infection in nasopharyngeal carcinoma. Head Neck. 2018 Jul;40(7):1515-1523. 7. Liu J., Li Y., Andiappan A., Yan Y., Tan K., Ong H., Thong K., Ong Y., Yu F., Low H., Zhang Y., Shi L., Wang D. Role of IL-13R α2 in modulating IL-13 induced MUC5AC and ciliary changes in healthy and CRSwNP mucosa.   Allergy. 2018 Aug;73(8):1673-1685. 8. Yu F*(corresponding author), Lu Y, Tao L, et al., Non-malignant nasopharyngeal epithelial cells preferentially proliferate from NPC biopsies cultured under conditionally reprogrammed conditions. Sci Rep. 2017 Dec 12;7(1):17359. doi: 10.1038/s41598-017-17628-z. 9. Jiang Y, Mayakonda A, Huang M, Ding L, Lin H, Yu F, Lu Y, Loh T et al., Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma. Cancer Res. 2017 Sep 26. pii: canres.1143.2017. doi: 10.1158/0008-5472.CAN-17-1143. [Epub ahead of print] 10. Tan, L. S. Y., Fredrik, P., Ker, L., Yu, F. G., Wang, D. Y., Goh, B. C., Loh, K. S., and Lim, C. M. (2016) High-risk HPV genotypes and P16INK4a expression in a cohort of head and neck squamous cell carcinoma patients in Singapore. Oncotarget 7, 86730 11. Yu F*(corresponding author), Tan W, Lu Y, Loh K. The other side of the coin: leveraging Epstein–Barr virus in research and NPC therapy. Oral Oncol. 2016 Sep;60:112-7. Review. 12. Li, Y. Y., Liu, J., Li, C. W., Subramaniam, S., Chao, S. S., Yu, F. G., Cohen, N. A., Li, S., and Wang, Y. (2016) Myrtol standardized affects mucociliary clearance. International Forum of Allergy & Rhinology, Wiley Online Library 13. Yu F*(corresponding author), Loh K. Cancer stem cells in nasopharyngeal carcinoma: current evidence. J Nasopharyng Carcinoma, 2014, 1(1): e6. doi:10.15383/jnpc.6. (Invited review). 14. Y.Y. Li, C.W. Li, S.S. Chao, F.G. Yu, X.M. Yu, J. Liu, Y. Yan, L. Shen, W. Gordon, L. Shi, Impairment of cilia architecture and ciliogenesis in hyperplastic nasal epithelium from nasal polyps. Journal of Allergy and Clinical Immunology (2014). 15. Yu F*(corresponding author), Tao L, Petersson F, Loh KS. Circulating Tumor Cells or Not?. Austin J Otolaryngol. 2014;1(4): 1. 16. N Sachewsky, R Leeder, W Xu, K. Rose, F Yu, D van der Kooy, C. Morshead. Primitive Neural Stem Cells in the Adult Mammalian Brain Give Rise to GFAP-Expressing Neural Stem Cells. Stem Cell Reports , Volume 2, Issue 6, p810–824, 3 June 2014. 17. Yu XM, Li CW, Chao SS, Li YY, Yan Y, Zhao XN, Yu FG, Liu J, Shen L, Pan XL, Shi L, Wang de Y. Reduced growth and proliferation dynamics of nasal epithelial stem/progenitor cells in nasal polyps in vitro. Sci Rep. 2014 Apr 9;4:4619. doi: 10.1038/srep04619. 18. De-Chen Lin, Xuan Meng Yasunobu Nagata, Ana Maria Varela, Liang Xu, Yusuke Sato, Li-Zhen Liu, Henry Yang, Boon Cher Goh, Soo Chin Lee, Bengt Fredrik Petersson, Yu F, Seishi Ogawa, Kwok Seng Loh, and H. Phillip Koeffler. The genomic landscape of nasopharyngeal carcinoma. Nature Genetics. 2014 Jun 22. doi: 10.1038/ng.3006. [Epub ahead of print]. 19. Ramasamy S, Yu F, Yu YH, Srivats H, Dawe GS, Ahmed S.NogoR1 and PirB signaling stimulates neural stem cell survival and proliferation. Stem Cells. 2014 Jan 21. 20. Yu F*(corresponding author), Hsieh W, Petersson F et al. Malignant cells derived from 3T3 fibroblast feeder layer in cell culture for nasopharyngeal carcinoma. Exp Cell Res. 2013 Dec 22. pii: S0014-4827 21. Yu F *(corresponding author), Sim S , Li C, Li Y, Zhao X, Wang D, Loh K. Identification of a subpopulation of nasopharyngeal carcinoma cells with cancer stem-like cell properties by high aldehyde dehydrogenase activity. Laryngoscope. 2013 Apr 24. doi: 10.1002/lary.24003. [Epub ahead of print] 22. Yu F, Li Y, Morshead CM. Induced pluripotent stem cells for the treatment of stroke: the potential and the pitfalls. Curr Stem Cell Res Ther. 2013 Sep;8(5):407-14. 23. Piccin D, Yu F*(co-first author), Morshead C. Notch signaling imparts and preserves neural stem characteristics in the adult brain. Stem Cells Dev. 2012 Dec 23. [Epub ahead of print] 24. Zhao X, Yu F *(co-first author), Li C, Li Y, Chao SS, Loh WS, Pan X, Shi L, Wang DY. The use of nasal epithelial stem/progenitor cells to produce functioning ciliated cells in vitro. Am J Rhinol Allergy. 2012 Jul 31. [Epub ahead of print] 25. Yu F, Zhao X, Li C, Li Y, Yan Y, Shi L, Gordon BR, Wang DY. Airway stem cells. Laryngoscope. 2012 Jul;122(7):1463-9. doi: 10.1002/lary.23320. Epub 2012 May 3. 26. Yu F, Morshead CM. Adult Stem Cells and Bioengineering Strategies for the Treatment of Cerebral Ischemic Stroke. Curr Stem Cell Res Ther. 2011 Apr 11. [Epub ahead of print] 27. Erlandsson A, Lin CH, Yu F, Morshead CM. Immunosuppression promotes endogenous neural stem and progenitor cell migration and tissue regeneration after ischemic injury. Exp Neurol. 2011 Jul;230(1):48-57. Epub 2010 Jun 1. 28. Lian Q, Yeo K, Que J, Tan EK, Yu F, Yin Y, Salto-Tellez M, El Oakley RM, Lim SK. Establishing clonal cell lines with endothelial-like potential from CD9(hi), SSEA-1(-) cells in embryonic stem cell derived embryoid bodies. PLoS ONE. 2006 Dec 20;1 :e6. 29. Yu F, Qi G, Liu Y, Gao S, Kan B. Construction and characterization of a thyA mutant derived from cholera vaccine candidate IEM101. Molecular Biotechnology,2005, March (29), 191-196. 30. Liang W, Wang S, Yu F, Zhang L, Qi G, Liu Y, Gao S, Kan B.Construction and evaluation of a safe, live, oral Vibrio cholerae vaccine candidate, IEM108. Infect Immun. 2003 Oct;71(10):5498-504. 31. Xu G, Nie DY, Chen JT, Wang CY, Yu FG, Sun L, Luo XG, Ahmed S, David S, Xiao ZC. Recombinant DNA vaccine encoding multiple domains related to inhibition of neurite outgrowth: a potential strategy for axonal regeneration. J Neurochem .2004Nov; 91(4):1018-23. 32. Cui XY, Hu QD, Tekaya M, Shimoda Y, Ang BT, Nie DY, Sun L, Hu WP, Karsak M, Duka T, Takeda Y, Ou LY, Dawe GS, Yu FG, Ahmed S, Jin LH, Schachner M, Watanabe K, Arsenijevic Y, Xiao ZC. NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes. J Biol Chem. 2004, Jun 11; 279(24):25858-65.

学术兼职

先后任新加坡国立大学耳鼻喉系首席研究员，复恩特（上海）生物技术公司中国区研发中心总监。