当前位置: X-MOL首页全球导师 国内导师 › 蓝平

个人简介

蓝平,博士,副研究员,硕士生导师。现任暨南大学先进与应用化学合成研究院副院长。主目前主持科研项目包括国家自然科学基金青年项目1项,教育部海外名师项目1项,中央高校科研培育与创新基金1项,广州市企业横向项目2项。截止2019年2月,共发表SCI收录论文47篇,英文专著2篇,其中第一作者/通讯作者论文24篇,主要发表在Organic Letters, Journal of Organic Chemistry, Journal of Natural Products(天然产物全合成研究成果)和Journal of Agricultural and Food Chemistry(食品添加剂研究成果)等专业TOP期刊上。 学习经历工作经历 2011.10-2015.01 澳大利亚国立大学化学研究院哲学(有机化学)博士 导师:Martin G. Banwell教授(澳大利亚科学院院士) 研究方向为天然产物全合成 2008.09-2011.06 暨南大学药学院医学硕士(药物化学专业) 导师:陈卫民教授 研究方向为天然产物的结构修饰 2004.09-2008.06 中南民族大学生命科学学院理学学士(药学专业 2018.11至今 暨南大学先进与应用化学合成研究院 副院长 2016.12至今 暨南大学理工学院食品科学与工程系副高(绿色通道) 2015.10-2016.12 澳大利亚沃尔特伊丽莎医学研究所(The Walter and Eliza Hall Institute of Medical Research)博士后研究员 合作导师:Peter M. Colman教授(澳大利亚科学院院士) Guillaume Lessene副教授及Peter Czabotar副教授 承担课题 1.基于稠环偕二卤代环丙烷不对称开环反应的天然产物全合成研究,国家自然科学基金(青年项目),2019-2021,25万,主持,编号:21801094 2.Fissitungfine A的全合成与抗增殖活性研究,科研培育与创新基金,2017-2020,15万,主持,编号:21617327 3.“功能性食品配料绿色合成研究”(澳大利亚国立大学Martin G. Banwell院士合作),教育部海外名师项目,2018-2023,100万,主持,编号:2018-HWMS001 4.高纯度蔗糖脂肪酸单酯绿色制备研究,横向课题,广州嘉德乐生化科技有限公司,2018-2021,10万,主持 5.糖尿病相关基因精准分型项目,横向课题,广州普麦健康咨询有限公司,2019-2022,50万,主持 6.山苍子精油绿色萃取及综合利用技术开发与产业化示范,广东省“扬帆计划”引进创新创业团队,2017-2022,300万,参与 研究方向为化学生物学 2015.02-2015.10 澳大利亚国立大学化学研究院博士后研究员 合作导师:Lewis N. Mander教授(澳大利亚科学院院士) 研究方向为天然产物全合成 发明专利 1. 叶文才,陈卫民,蓝平,张冬梅,王娇,舒畅,曹惠惠,于淼。23-羟基白桦酸衍生物及其制备方法和用途。中国发明专利 (公开号CN102108092A) 讲授课程 1. 《Food Additives》本科生全英授课 2. 《有机合成》本科生

研究领域

主要研究方向为有机合成化学,包括: 1. 天然产物全合成,即运用有机合成相关技术以来源广泛的简单有机物为原料,制备具有生物活性的天然产物; 2. 新型食品添加剂的研发与制备,主要致力于运用绿色合成技术,开发安全、高效的新型食品添加剂(乳化剂);

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

49. Lan, P.; Banwell, M. G.*; Willis, A. C. Application of electrocyclic ring-opening and desymmetrizing nucleophilic trappings ofmeso-6,6-dibromobicyclo[3.1.0]hexanes to total syntheses of crinine and haemanthamine alkaloids.J. Org. Chem.2019,84, 3431–3466. 影响因子(4.849)引用次数(0)A1二区 48. Zhang, Z.; Liu, Y.; Chen, Y.*; Li, L.;Lan, P.; He, D.; Song, J.*; Zhang, Y.* Transdermal delivery of 5-aminolevulinic acid by nanoethosome gels for photodynamic therapy of hypertrophic scars. ACS Appl. Mater. Inter.2019, 11, 3704–3714. 影响因子(8.097)引用次数(0)A1一区 47. Mikusek, J.; Nugent, J.;Lan, P.; Banwell, M. G.* A chemical synthesis study establishes the true structure of the potent anti-inflammatory agent myrsinoic acid F.J. Nat. Prod.2019,82, 96–100. 影响因子(3.885)引用次数(0)A1二区 46. Benoit, B.; Tang, F.;Lan, P., Willis, A. C.; Banwell, M. G.* Synthetic studies on the marine-derived sesquiterpene (+)-viridianol: divergent behaviour of two structurally related, ring-fused cyclopropanes under the same hydrogenolytic conditions.Aust. J. Chem. Published online, https://doi.org/10.1071/CH18532 影响因子(1.558)引用次数(0)A2四区 45. Lan, P.; Banwell, M. G.* Diastereoselective alkylation, allylation and benzylation reactions (of derived amides).Encyclopedia of Reagents for Organic Synthesis (e-EROS)2019, In press 著作章节 44. Tang, F.;Lan, P.; Benoit, B.; Banwell, M. G.*; Willis, A. C.Total synthesis of (+)-viridianol, a marine-derived sesquiterpene embodying thedecahydrocyclobuta[d]indene framework.J. Org. Chem.2018, 83, 14049–14056. 影响因子(4.849)引用次数(3)A1二区 43. Yao, N.; Wang, C.; Hu, N.; Li, Y.; Liu, M.; Lei, Y.; Chen, M.; Chen, L.; Chen, C.;Lan, P.; Chen, W. M.; Chen, Z.; Ye, W. C.*; Zhang, D. M.* Inhibition of PINK1/Parkin-dependent mitophagy sensitizes multidrug-resistant cancer cells to the betulinic acid analogue B5G1.Cancer Lett. In press 影响因子(6.491)引用次数(0)A1二区 42. Liang, M. Y.; Banwell, M. G.; Wang, Y.*;Lan, P.* Effect of variations in the fatty acid residue of lactose monoesters on their emulsifying properties and biological activities. J. Agric. Food Chem.2018,66, 12594–12603. 影响因子(3.412)引用次数(1)A1一区 41. Qiu, Y.; Dlugosch, M.; Liu, X.; Khan, F.; Ward, J. S.;Lan, P.; Banwell, M. G.* The reductive cyclisation ofo-nitroarylated-α,β-unsaturated aldehydes and ketones with TiCl3/HCl or Fe/HCl leading to 1,2,3,9-tetrahydro-4H-carbazol-4-ones and related heterocycles.J. Org. Chem.2018,83, 12023–12033. 影响因子(4.849)引用次数(0)A1二区 40. Moujalled, D.; Pomilio, G.; Ghiurau, C.; Segal, D.; The, T. C.; Salmon, J.; Rijal, S.;Lan, P.; Kraus-Berthier, L.; Roberts, A.; Huang, D.; Maragno, A. L.; Lessene, G.; Geneste, O.; Wei, A.* A chemotherapy-free approach co-targeting pro-survival BCL-2 and MCL1 is highly efficacious in acute myeloid leukemia.Leukemia published online https://doi.org/10.1038/s41375-018-0261-3 影响因子(13.164)引用次数(2)A1一区 39. Ma, Y. R.; Banwell, M. G.; Yan, R.*;Lan, P.* Comparative study of the emulsifying properties of a homologous series of long-chain 6ʹ-O-acylmaltose esters.J. Agric. Food Chem.2018,66, 8832–8840. 影响因子(3.412)引用次数(1)A1一区 38. Lan, P.; Banwell, M. G.*; Willis, A. C. Total synthesis of (±)-crinane from 6,6-dibromobicyclo[3.1.0]hexane and using a 5-exo-trig radical cyclisation reaction to assemble the requisite C3a-arylated perhydroindole.J. Org. Chem.2018,83, 8493–8498. 影响因子(4.849)引用次数(2)A1二区 37. Bon, D. J.-Y. D.; Mander, L. N.*;Lan, P.*Syntheses of gibberellins A15 and A24, the key metabolites in gibberellin biosynthesis.J. Org. Chem.2018,83, 6566–6572. 影响因子(4.849)引用次数(0)A1二区 36. Xiang, L.; Chen, J.; Yang, Y.; Xie, D.; Li, Y.; Liu, F.; Ma, H.; Wu, F.; Chen, K.;* Wu, H.;Lan, P.; Yuan, G.; Li, S.; Wang, Y.; Liu, J.; Zhu, J. Enhanced high permittivity and lowed dielectric loss in cellulose-fibre framework polymer microcomposites.Polym. Composite. 2018, Article DOI: 10.1002/pc.24892 影响因子(2.324)引用次数(0)A2三区 35. Liang, M. Y.; Chen, Y.; Banwell, M. G.; Wang, Y.*;Lan, P.* Enzymatic preparation of a homologous series of long-chain 6-O-acylglucose esters and their evaluation as emulsifiers.J. Agric. Food Chem.2018, 66, 3949–3956. 影响因子(3.412)引用次数(1)A1一区 34. Chen, Y.;Lan, P.*TotalSyntheses and biological evaluation of theGanoderma lucidum alkaloids lucidimines B and C. ACS Omega2018, 3,3471–3481. 影响因子()引用次数(0)新期刊,暂无分区 33. Lan, P.*; Herlt, A. J.; Willis, A. C.; Taylor, W. C.; Mander, L. N.*Structures of New Alkaloids fromrain forest trees Galbulimima belgraveana andGalbulimima baccata in Papua New Guinea, Indonesia and Northern Australia.ACS Omega2018,3, 1912–1921. 影响因子()引用次数(1)新期刊,暂无分区 32. Taher, E. S.; Banwell, M. G.*; Buckler, J. N.; Yan, Q.;Lan, P.The exploitation of enzymatically-derivedcis-1,2-dihydrocatechols and related compounds in the synthesis of biologically active natural products.Chem. Rec.2018,18, 239–264. 影响因子(3.855)引用次数(7)A1二区 31. Jian, J.; Fan, J.; Yang, H.; Lan, P.; Li, M.; Liu, P.; Gao, H.*; Sun, P. H.*Totalsynthesis oftheflavonoid natural product Houttuynoid A fromhouttuynia cordata.J. Nat. Prod.2018,81, 371–377. 影响因子(3.798)引用次数(2)A1二区 30. Zhao, Q.; Zou, Y.; Huang, C.;Lan, P.; Zheng, J.; Ou, S.* Formation of a hydroxymethylfurfural-cysteine adduct and its absorption and cytotoxicity in Caco-2 cells.J. Agric. Food Chem.2017,65, 9902–9908. 影响因子(3.412)引用次数(4)A1一区 29. Brouwer, J. M.;Lan, P.; Cowan, A. D.; Bernardini, J. P.; Birkinshaw, R. W.; van Delft, M. F.; Sleebs, B. E.; Robin, A. Y.; Wardad, A.; Tan, I. K.; Reljic, B.; Lee, E. F.; Fairlie, W. D.; Call, M. J.; Smith, B. J.; Dewson, G.; Lessene, G.; Colman, P. M.; Czabotar, P. E.* Conversion of Bim-BH3 from activator to inhibitor of Bak through structure-based design.Mol. Cell 2017,68, 659–672. 影响因子(14.713)引用次数(6)A1一区 28. Banwell, M. G.; Bolte, B.; Buckler, J. N.; Chang, E. L.;Lan, P.; Taher, E. S.; White, L. V.; Willis, A. C. Chemoenzymatic pathways for the synthesis of biologically active natural products.Journal and Proceedings of the Royal Society of New South Wales2016,149, 34–50. 影响因子(1.124)引用次数(9)A2四区 27. Chang, E. L.; Benoit, B.;Lan, P.; Willis, A. C.; Banwell, M. G.*Chemoenzymatic total syntheses of the enantiomers of the protoilludanes 8-deoxydihydrotsugicoline and radudiol. J. Org. Chem.2016,81, 2078–2086. 影响因子(4.849)引用次数(12)A1二区 26. Lan, P.; White, L. E.;Taher, E. S.;Guest, P. E.; Banwell, M. G.*; Willis, A. C. Chemoenzymatic synthesis of (+)-asperpentyn and the enantiomer of the structure assigned to aspergillusol A.J. Nat. Prod.2015,78, 1963–1968. 影响因子(3.798)引用次数(12)A1二区 25. Lan, P.; Banwell, M. G.*; Willis, A. C.Chemoenzymatic synthesis of the enantiomer of 4,12-dihydroxysterpurene, the structure assigned to a metabolite isolated from the culture broth ofStereum purpureum.Org. Lett.2015,17, 166–169. 影响因子(6.579)引用次数(12)A1一区 24. Crisp, A. L.; Li, J.;Lan, P.; Nugent, J.; Matousova, E.; Banwell, M. G.* The Palladium-catalysed intramolecular Alder-ene (IMAE) reactions of certain heteroatom-linked 1,6-enynes: the formation of hexahydro-indoles and –benzofurans.Aust. J. Chem.2015,68, 1183–1189. 影响因子(1.558)引用次数(8)A2四区 23. White, L. V.;Lan, P.; Schwartz, B. D.; Willis, A. C.; Banwell, M. G.* New, homochiral synthons obtained through simple manipulations of enzymatically-derived 3-halo-cis-1,2-dihydrocatechols.Aust. J. Chem. 2015,68, 1467–1471. 影响因子(1.558)引用次数(5)A2四区 22. Banwell, M. G.*; Buckler, J.; Jackson, C. J.;Lan, P.; Ma, X.; Matousova, E.; Nugent, J. Devising new syntheses of the alkaloid galanthamine, a potent and clinically deployed inhibitor of acetylcholine esterase.Strategies and Tactics in Organic Synthesis2015,11, 29–50. 著作章节,引用次数(3) 21. Yao, N.; Li, Y. J.; Zhang, D. M.; Liu, D. L.; Tang, M. K.; Yiu, A.; Li, Y.; Chen, W. M.; Lan, P.; Yao, Z.; Chen, Z. S.; Ye, W. C.* B4G2 induces mitochondrial apoptosis by the ROS-mediated opening of Ca2+-dependent permeability transition pores.Cell. Physiol. Biochem.2015,37, 838–852. 影响因子(2.875)引用次数(9)A1二区 20. Lan, P.;Jackson,C. J.;Banwell, M. G.*; Willis, A. C.Synthesis of a D-ring isomer of galanthaminevia a radical-based Smiles rearrangement reaction.J. Org. Chem.2014,79, 6759–6764. 影响因子(4.849)引用次数(15)A1二区 19. Lan, P.; Banwell, M. G.*; Willis, A. C.Chemoenzymatic total syntheses of ribisins A, B and D, polyoxygenated benzofuran derivatives displaying NGF-potentiating properties.J. Org. Chem.2014,79, 2829–2842. •被选为重点推荐论文 影响因子(4.849)引用次数(26)A1二区 18. Lan, P.; Banwell, M. G.*; Ward, J. S.; Willis, A. C.Chemoenzymatic total synthesis and reassignment of the absolute configuration of ribisin C.Org. Lett.2014,16, 228–231. 影响因子(6.579)引用次数(9)A1一区 17. Zhang, D. M.; Li, Y. J.; Shu, C.; Ruan, Z. X.; Chen, W. M.; Yiu, A.; Peng, Y. H; Wang, J.;Lan, P.; Yao, Z.; Fung, K. P.; Fu, L. W.; Chen, Z. S.*; Ye, W. C.* Bipiperidinyl derivatives of 23-hydroxybetulinic acid reverse resistance of HepG2/ADM and MCF-7/ADR cells. Anti-Cancer Drugs2013,24, 441–454. 影响因子(1.784)引用次数(8)A2三区 16. Lan,P.;Wu, Z. W.; Chen, W. N.; Sun, P. H.; Chen, W. M.* Molecular modeling studies on phosphonic acid-containing thiazole derivatives: design for fructose-1,6-bisphosphatase inhibitors.J. Mol. Model. 2012,18, 973–990. 影响因子(1.736)引用次数(3)A2四区 15. Zhang, D. M.; Shu, C.; Chen, J. J.; Sodani, K.; Wang, J.; Bhatnagar, J.;Lan, P.; Ruan, Z. X.; Xiao, Z. J.; Ambudkar, S. V.; Chen, W. M.; Chen, Z. S.*; Ye, W. C.* BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistancein vitro andin vivo.Mol. Pharmaceut.2012,9, 3147–3159. 影响因子(4.384)引用次数(39)A1二区 14. Lan, P.;Wang, J.; Zhang, D. M.; Shu, C.; Cao, H. H.; Sun, P. H.; Wu, X. M.; Ye, W. C.*; Chen, W. M.* Synthesis andantiproliferative evaluationof 23-hydroxybetulinic acid derivatives.Eur. J. Med. Chem. 2011,46, 2490–2502. 影响因子(4.816)引用次数(24)A1二区 13. Lan,P.;Chen, W. N.; Chen, W. M.* Molecular modeling studies on imidazo[4,5-b]pyridine derivatives as Aurora A kinase inhibitors using 3D-QSAR and docking approaches.Eur. J. Med. Chem.2011,46, 77–94. 影响因子(4.816)引用次数(38)A1二区 12. Lan,P.;Chen, W. N.; Huang, Z. J.; Sun, P. H.; Chen, W. M.*Understanding the structure-activity relationship of betulinic acid derivatives as anti-HIV-1 agents by using 3D-QSAR and docking. J. Mol. Model.2011, 17, 1643–1659. 影响因子(1.736)引用次数(17)A2四区 11. Lan,P.;Sun, J. R.; Chen, W. N.; Sun, P. H.; Chen, W. M.* Molecular modeling studies ond-annulated benzazepinones as VEGF-R2 kinase inhibitors using docking and 3D-QSAR.J. Enzym. Inhib. Med. Chem.2011,26, 367–377. 影响因子(3.638)引用次数(8)A1二区 10. Lan,P.;Chen, W. N.; Sun, P. H.; Chen, W. M.* 3D-QSAR and molecular docking studies of azaindole derivatives as Aurora B kinase inhibitors.J. Mol. Model.2011,17, 1191–1205. 影响因子(1.736)引用次数(11)A2四区 9. Lan,P.;Chen, W. N.; Sun, P. H.; Chen, W. M.* 3D-QSAR studies on betulinic acid and betulin derivatives as anti-HIV-1 agents using CoMFA and CoMSIA.Med. Chem. Res.2011,20,1247–1259. 影响因子(1.402)引用次数(4)A2四区 8. Sun, J. R.;Lan, P.; Sun, P. H.; Chen, W. M.* 3D-QSAR and docking studies on pyrrolopyrimidine derivatives as LIM-Kinase 2 inhibitors. Lett. Drug Des. Discov.2011,8, 229–240. 影响因子(1.170)引用次数(8)A2四区 7. Huang, Z. J.; Zeng, Y.;Lan, P.; Sun, P. H.; Chen, W. M.* Advances in structural modifications and biological activities of berberine: an active compound in traditional Chinese medicine.Mini-Rev. Med. Chem.2011,11, 1122–1129. 影响因子(2.645)引用次数(41)A2三区 6. Song, Q. L.; Guo, B. Q.; Zhang, W.;Lan,P.;Sun, P. H.; Chen, W. M.* Design, synthesis and antibacterial activity of novel ketolides bearing an aryltetrazolyl-substituted alkyl side chain.J. Antibiot.2011,64, 571–581. 影响因子(2.150)引用次数(6)A2三区 5. Wu, X.;Lan, P.; Liu, Z.; Ruan, Z. X.; Wang, H.; Wang, G. C.; Ye, W. C.; Li, Y. L. 3D-QSAR studies of natural steroidal saponins as anticancer agents in human nasopharyngeal carcinoma epithelial cells.Lett. Drug Des. Discov.2013,10, 245–252. 影响因子(1.170)引用次数(1)A2四区 4. Lan,P.;Xie, M. Q.; Yao, Y. M.; Chen, W. N.; Chen, W. M.* 3D-QSAR studies and molecular docking on [5-(4-Amino-1H-benzoimidazol-2-yl)-furan-2-yl]-phosphonic acid derivatives as fructose-1, 6-biphophatase inhibitors.J. Comput. Aided Mol. Des.2010,24, 993–1008. 影响因子(2.990)引用次数(11)A2三区 3. Lan,P.;Chen, W. N.; Xiao, G. K.; Sun, P. H.; Chen, W. M.* 3D-QSAR and docking studies on pyrazolo[4,3-h]quinazoline-3-carboxamides as cyclin-dependent kinase 2 (CDK2) inhibitors.Bioorg. Med. Chem. Lett. 2010,20, 6764–6772. 影响因子(2.420)引用次数(36)A2三区 2. Lan,P.;Huang, Z. J.; Sun, J. R.; Chen, W. M.* 3D-QSAR and molecular docking studies on fused pyrazoles as p38α mitogen-activated protein kinase inhibitors.Int. J. Mol. Sci.2010,11, 3357–3374. 影响因子(2.862)引用次数(27)A2三区 1. Hu, L.;Lan, P.;Song, Q. L.; Huang, Z. J.; Sun, P. H.; Zhuo, C.; Wang, Y.; Xiao, S.; Chen, W. M.* Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides.Eur. J. Med. Chem.2010,45, 5943–5949. 影响因子(3.447)引用次数(12)A1二区

推荐链接
down
wechat
bug