Dixon, Darren - University of Oxford - Department of Chemistry

个人简介

Darren studied at the University of Oxford where he received his Masters degree in 1993 and his DPhil in 1997 for work supervised by Prof Stephen G. Davies. After postdoctoral work with Professor Steven V. Ley CBE, FRS, he joined the faculty at the Department of Chemistry in Cambridge in 2000. In 2004 he took a Senior Lecturership at The University of Manchester and in 2007 he was promoted to Reader. In 2008 he moved to his current post at the University of Oxford where he is Professor of Chemistry and is the Knowles-Williams Tutorial Fellow in Organic Chemistry at Wadham College. His research program is centered on catalysis and synthetic organic chemistry and focusses on the development of new catalyst-enabled enantioselective synthetic methodologies and their application in synthesis.

研究领域

The Dixon group invents new synthetically powerful methodologies - founded on new catalyst-enabled reactivity - that simplify the synthesis of structurally complex scaffolds, natural products and molecules of biological significance. We enjoy tackling reactions that have no precedent in the literature and strive to make the resulting methodologies attractive to synthesis chemists by developing protocols that are operationally simple, predictable, efficient, selective and scalable. A predominant focus of our group is catalytic stereoselective synthesis and we have published extensively on new, highly enantioselective methods development, total synthesis of complex natural products, new cooperative catalyst designs, and new cascade reactions.

近期论文

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"Bifunctional Iminophosphorane Catalysed Enantioselective Sulfa-Michael Addition of Alkyl Thiols to Alkenyl Benzimidazoles", M. Formica, G. Sorin, A. J. M. Farley, J. Díaz, R. S. Paton and D. J. Dixon Chem. Sci. 2018 DOI: 10.1039/C8SC01804A "Iridium-catalyzed reductive Ugi-type reactions of tertiary amides", L.-G. Xie, D. J. Dixon Nat. Comm. 2018 DOI: 10.1038/s41467-018-05192-7 "Photocatalytic reverse polarity Povarov reaction", J. A. Leitch, A. L. Fuentes de Arriba, J. Tan, O. Hoff, C. M. Martinez, D. J. Dixon Chem. Sci 2018 "Bifunctional iminophosphorane superbases: Potent organocatalysts for enantio- and diastereoselective Michael addition reactions", A. J. M. Farley, P. Jakubec, A. M. Goldys, D. J. Dixon Tetrahedron 2018, 10.1016/j.tet.2018.06.021 "Measuring Spin Relaxation Rates Using Satellite Exchange NMR Spectroscopy", G. P. Robertson, B. Odell, I. Kuprov, D. J. Dixon, T. D. W. Claridge, Angew. Chem. Int. Ed. 2018, 10.1001/anie.201801322 "Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (P14) macrodomain 2" M. Moustakim, K. Riedeld, M. Schuller, A. P. Gehring, O. P. Monteiro, S. P. Martine, O. Fedorov, J. Heer, D. J. Dixon, J. M. Elkins, S. Knapp, F. Bracher, P. E. Brennan, Bioorg. Med. Chem. 2018, 10.1016/j.bmc.2018.03.020 "Direct sulfonylation of anilines mediated by visible light" T. C. Johnson, B. L. Elbert, A. J. M. Farley, T. W. Gorman, C. Genicot, B. Lallemand, P. Pasau, J. Flasz, J. L. Castro, M. MacCoss, D. J. Dixon, R. S. Paton, C. J. Schofield, M. D. Smith and M. C. Willis, Chem. Sci. 2017 DOI: 10.1039/C7SC03891G "Total synthesis of (−)-himalensine A" H. Shi, I. N. Michaelides, B. Darses, P. Jakubec, Q. N. N. Nguyen, R. S. Paton, and D. J. Dixon, J. Am. Chem. Soc. 2017 DOI: 10.1021/jacs.7b10956 "Thioamide Directed Co(III) Catalyzed Selective Amidation of C(sp3)-H Bonds" P. W. Tan, A. M. Mak, M. B. Sullivan, D. J. Dixon and J. Seayad Angew. Chem. Int. Ed. 2017 DOI: 10.1002/anie.201709273 "C-H Cyanation of 6-Ring N-Containing Heteroaromatics" B. L. Elbert, A. J. M. Farley, T. W. Gorman, T. C. Johnson, C. Genicot, B. Lallemand, P. Pasau, J. Flasz, J. L. Castro, M. MacCoss, R. S. Paton, C. J. Schofield, M. D. Smith, M. C. Willis and D. J. Dixon, Chem. Eur. J. 2017 DOI: 10.1002/chem.201703931 "Tertiary amine synthesis via reductive coupling of amides with Grignard reagents" L.-G. Xie, D. J. Dixon, Chem. Sci. 2017, DOI: 10.1039/C7SC03613B "α-Alkylation of ketimines using visible light photoredox catalysis" A. Franchino, T. Rinaldi, D. J. Dixon, RSC Adv. 2017, 7, 43655-43659 "Enantioselective Silver and Amine Co-catalyzed Desymmetrizing Cycloisomerization of Alkyne-linked Cyclohexanones" R. Manzano, S. Datta, R. S. Paton, D. J. Dixon, Angew. Chem. Int. Ed. 2017, DOI: 10.1002/anie.201612048 "Enantioselective Construction of the ABCDE Pentacyclic Core of the Strychnos Alkaloids" Adam D. Gammack Yamagata and Darren J. Dixon, Org. Lett. 2017, DOI: 10.1021/acs.orglett.7b00669 "Iridium-Catalyzed Reductive Strecker Reaction for Late-Stage Amide and Lactam Cyanation" A. L. Fuentes de Arriba, E. Lenci, M. Sonawane, O Formery, D. J. Dixon, Angew. Chem. Int. Ed. 2017, DOI: 10.1002/anie.201612367 "Discovery of a PCAF Bromodomain Chemical Probe" M. Moustakim, P. G. K. Clark, L. Trulli, A. L. Fuentes de Arriba, M. T. Ehebauer, A. Chaikuad, E. J. Murphy, J. Mendez-Johnson, D. Daniels, C.-F. D. Hou, Y.-H. Lin, J. R. Walker, R. Hui, H. Yang, L. Dorrell, C. M. Rogers, O. P. Monteiro, O. Fedorov, K. V. M. Huber, S. Knapp, J. Heer, D. J. Dixon, P. E. Brennan, Angew. Chem. Int. Ed. 2017, 56, 827–831 "Enantioselective Bifunctional Iminophosphorane Catalyzed Sulfa-Michael Addition of Alkyl Thiols to Unactivated β-Substituted-α,β-Unsaturated Esters" J. Yang, A. J. M. Farley, D. J. Dixon, Chemical Science, 2017, 8, 606–610 "Umpolung Synthesis of Branched α-Functionalized Amines from Imines via Photocatalytic Three-Component Reductive Coupling Reactions" A. L. Fuentes de Arriba, F. Urbitsch and D. J. Dixon, Chem. Commun., 2016, 52, 14434–14437 "Chemical probes and inhibitors of bromodomains outside the BET family" M. Moustakim, P. G. K. Clark, D. A. Hay, D. J. Dixon, P. E. Brennan, Med. Chem. Commun, 2016, 7, 2246–2264 "Expeditious and Divergent Total Syntheses of Aspidosperma Alkaloids Exploiting Iridium(I)-Catalyzed Generation of Reactive Enamine Intermediates" P. W. Tan, J. Seayad, D. J. Dixon, Angew. Chem. Int. Ed. 2016, 55, 13436–13440