个人简介

MD BS (Melb), FRCPA, FRCPath (UK), MIAC, AFRACMA. Professor Lee is Professor and Chair of Pathology at University of Western Sydney. He is currently based at Liverpool Hospital and is a senior pathologist at that hospital and at Royal Prince Alfred Hospital. He has research interests in cancer pathology particularly in relation to translational work in gastrointestinal, breast, pancreatic-biliary, head and neck and prostate cancers. His work on EGFR in head and neck cancers in the early 1990's resulted in the first and only one of two publications in this area in Australia that has recently resulted in the use of immunohistochemical detection of EGFR in patients with these cancers. His involvement in multicentre international study on phyllodes tumour of the breast has produced significant insights into the molecular basis of this unusual condition. He and his overseas collaborators from Hong Kong, Singapore and Brazil currently have the largest archival series of these tumours in the world. Professor Lee is currently Editor-in-Chief of the London-based journal, the Journal of Clinical Pathology, one of the world's most influential journal in Clinical Pathology. Hwas also prevsiouly the Editor-in-Chief of the journal, Pathology and is a member of the editorial board of the prestigious British Medical Journal (2010-2013). He has published over 160 manuscripts in high impact factor international journals in cancer research with over 4,600 citations to his publications, and his H-index is 39. His research programmes are currently funded by NHMRC, Cancer Institute NSW, Cancer Australia and Royal Australian and New Zealand College of Radiologists.

研究领域

Pathology

Breast Cancer Cancer Pathology Colorectal Cancer Cytology Head and Neck Cancer Pancreatic Cancer Prostate Cancer Surgical Pathology

近期论文

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Kalinowski, D., Stefani, C., Toyokuni, S., Ganz, T., Anderson, G., Subramaniam, N., Trinder, D., Olynyk, J., Lee, C. and [and eight others], .. (2016), 'Redox cycling metals : pedaling their roles in metabolism and their use in the development of novel therapeutics', Biochimica et Biophysica Acta, vol 1863, no 4 , pp 727 - 748. Zhang, X., Gee, H., Rose, B., Lee, C., Clark, J., Elliott, M., Gamble, J., Cairns, M., Harris, A. and [and two others], .. (2016), 'Regulation of the tumour suppressor PDCD4 by miR-499 and miR-21 in oropharyngeal cancers', BMC Cancer, vol 16, no 1 . Caixeiro, N., Lai, K. and Lee, C. (2016), 'Quality assessment and preservation of RNA from biobank tissue specimens : a systematic review', Journal of Clinical Pathology , vol 69, no 3 , pp 260 - 265. Ng, W., Shin, J., Roberts, T., Wang, B. and Lee, C. (2016), 'Molecular interactions of polo-like kinase 1 in human cancers', Journal of Clinical Pathology, vol 69, no 7 , pp 557 - 562. Pare, R., Shin, J. and Lee, C. (2016), '[In Press] Increased expression of senescence markers P14ARF and p16 INK4a in breast cancer is associated with increased risk of disease recurrence and poor survival outcome', Histopathology, . Hong, A., Lee, C., Jones, D., Veillard, A., Zhang, M., Zhang, X., Smee, R., Corry, J., Porceddu, S. and [and four others], .. (2016), 'Rising prevalence of human papillomavirus-related oropharyngeal cancer in Australia over the last 2 decades', Head & Neck , vol 38, no 5 , pp 743 - 750. Chng, T., Lee, J., Lee, C., Li, H., Tan, M. and Tan, P. (2016), '[In Press] Validation of the Singapore nomogram for outcome prediction in breast phyllodes tumours : an Australian cohort', Journal of Clinical Pathology, . Rajendra, S., Wang, B., Pavey, D., Sharma, P., Yang, T., Lee, C., Gupta, N., Ball, M., Gill, R. and Wu, X. (2015), 'Persistence of human papillomavirus, overexpression of p53 and outcomes of patients after endoscopic ablation of Barrett's esophagus', Clinical Gastroenterology and Hepatology, vol 13, no 7 , pp 1364 - 1368. Lai, K., Killingsworth, M. and Lee, C. (2015), 'Gene of the month : PIK3CA', Journal of Clinical Pathology, vol 68, no 4 , pp 253 - 257. Tut, T., Lim, S., Dissanayake, I., Descallar, J., Chua, W., Ng, W., de Souza, P., Shin, J. and Lee, C. (2015), 'Upregulated polo-like kinase 1 expression correlates with inferior survival outcomes in rectal cancer', PLoS One, vol 10, no 6 . Lim, S., Chua, W., Henderson, C., Ng, W., Shin, J., Chantrill, L., Asghari, R., Lee, C., Spring, K. and de Souza, P. (2015), 'Predictive and prognostic biomarkers for neoadjuvant chemoradiotherapy in locally advanced rectal cancer', Critical Reviews in Oncology/Hematology, vol 96, no 1 , pp 67 - 80. Liu, J., Zhang, M., Rose, B., Veillard, A., Jones, D., Zhang, X., Lee, C., Milross, C. and Hong, A. (2015), 'Ki67 expression has prognostic significance in relation to human papillomavirus status in oropharyngeal squamous cell carcinoma', Annals of Surgical Oncology, vol 22, no 6 , pp 1893 - 1900. Caixeiro, N., Aghmesheh, M., Souza, P. and Lee, C. (2015), 'The Centre for Oncology Education and Research Translation (CONCERT) Biobank', Open Journal of Bioresources, vol 2 . Caixeiro, N., Byun, H., Descallar, J., Levesque, J., de Souza, P. and Lee, C. (2015), '[In Press] Health professionals' opinions on supporting a cancer biobank : identification of barriers to combat biobanking pitfalls', European Journal of Human Genetics, . Zhang, M., Rose, B., Lee, C. and Hong, A. (2015), 'In vitro 3-dimensional tumor model for radiosensitivity of HPV positive OSCC cell lines', Cancer Biology & Therapy , vol 16, no 8 , pp 1231 - 1240.