个人简介

Jens trained in Canada (BSc, MSc, PhD) with subsequent Fellowships at the Max Planck Institute for Medical Research (Heidelberg) and the National Institutes of Health (USA). Following a NIH Visiting Scientist appointment he was an Associate Professor in the Faculty of Medicine/Hotchkiss Brain Institute, University of Calgary. In 2008 he was appointed Foundation Professor of Molecular Physiology at the new School of Medicine, University of Western Sydney. The Molecular Physiology Unit operates on the philosophy that only by understanding essential molecular mechanisms can we rationally address serious medical disorders, and that this also provides the best strategy for training the next generations of Biomedical Researchers, Clinical Scientists, and Physicians. We strive to make our teaching and training the best possible preparation and guide for our students to become those future colleagues we hold in the highest esteem. Research operates at the interface of physiology, biochemistry, physical chemistry, molecular biology and biophysics, coupling functional assays/diagnoses with proteomic and lipid analyses to dissect molecular mechanisms. A strong, quantitative Basic Biomedical research program provides solid grounding for Translational Research that addresses problems of more immediate clinical relevance. Much of this work grows from and is supported by a variety of local and international collaborations.

研究领域

Molecular Physiology

Cancer Proteomics/Lipidomics/Systems Biology Exocytosis/membrane fusion Memory deficits Preterm labour Seizure disorders Spinal cord/CNS injury Stroke/cardiovascular disease Synaptic mechanisms/plasticity

近期论文

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Partridge, M., Gopinath, S., Myers, S. and Coorssen, J. (2016), 'An initial top-down proteomic analysis of the standard cuprizone mouse model of multiple sclerosis', Journal of Chemical Biology, vol 9, no 1 , pp 9 - 18. Stimpson, S., Coorssen, J. and Myers, S. (2015), 'Mitochondrial protein alterations in a familial peripheral neuropathy caused by the V144D amino acid mutation in the sphingolipid protein, SPTLC1', Journal of Chemical Biology, vol 8, no 1 , pp 25 - 35. Mahadeo, M., Furber, K., Lam, S., Coorssen, J. and Prenner, E. (2015), 'Secretory vesicle cholesterol : correlating lipid domain organization and Ca2+ triggered fusion', Biochimica et Biophysica Acta, vol 1848, no 5 , pp 1165 - 1174. Partridge, M., Myers, S., Gopinath, S. and Coorssen, J. (2015), 'Proteomics of a conundrum : thoughts on addressing the aetiology versus progression of multiple sclerosis', Proteomics: Clinical Applications, vol 9, no 9-10 , pp 838 - 843. Stimpson, S., Coorssen, J. and Myers, S. (2015), 'Optimal isolation of mitochondria for proteomic analyses', Analytical Biochemistry, vol 475 , pp 1 - 3. Rogasevskaia, T. and Coorssen, J. (2015), 'The role of phospholipase D in regulated exocytosis', Journal of Biological Chemistry, vol 290, no 48 , pp 28683 - 28696. Stimpson, S., Coorssen, J. and Myers, S. (2015), 'Proteome alterations associated with the V144D SPTLC1 mutation that causes hereditary sensory neuropathy-I', Electronic Journal of Biology, vol 11, no 4 , pp 176 - 186. Coorssen, J. and Yergey, A. (2015), 'Proteomics is analytical chemistry : fitness-for-purpose in the application of top-down and bottom-up analyses', Proteomes, vol 3, no 4 , pp 440 - 453. Abbineni, P., Wright, E., Rogasevskaia, T., Killingsworth, M., Malladi, C. and Coorssen, J. (2014), 'The sea urchin egg and cortical vesicles as model systems to dissect the fast, Ca2+-triggered steps of regulated exocytosis', Neuromethods, vol 83 , pp 221 - 241. Wright, E., Partridge, M., Padula, M., Gauci, V., Malladi, C. and Coorssen, J. (2014), 'Top-down proteomics : enhancing 2D gel electrophoresis from tissue processing to high-sensitivity protein detection', Proteomics, vol 14, no 7-8 , pp 872 - 889. Marshall, L., Stimpson, S., Hyland, R., Coorssen, J. and Myers, S. (2014), 'Increased lipid droplet accumulation associated with a peripheral sensory neuropathy', Journal of Chemical Biology, vol 7, no 2 , pp 67 - 76. Oliveira, B., Coorssen, J. and Martins-de-Souza, D. (2014), '2DE : the phoenix of proteomics', Journal of Proteomics, vol 104 , pp 140 - 150. Wright, E., Prasad, K., Padula, M. and Coorssen, J. (2014), 'Deep imaging : how much of the proteome does current top-down technology already resolve?', PLoS One, vol 9, no 1 . Wright, E., Padula, M., Higgins, V., Aldrich-Wright, J. and Coorssen, J. (2014), 'A systems biology approach to understanding the mechanisms of action of an alternative anticancer compound in comparison to cisplatin', Proteomes, vol 2, no 4 , pp 501 - 526. Rituper, B., Chowdhury, H., Jorgacevski, J., Coorssen, J., Kreft, M. and Zorec, R. (2013), 'Cholesterol-mediated membrane surface area dynamics in neuroendocrine cells', Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, vol 1831, no 7 , pp 1228 - 1238.