Jensen, Slade - University of Western Sydney

个人简介

From 2005-2010 I was a research only academic in the School of Biological Sciences, University of Sydney, and in July 2010 became a Senior Lecturer in the School of Medicine, University of Western Sydney. I am interested in microbial evolution and the mechanisms that facilitate genetic exchange between bacteria. Horizontal gene transfer (HGT) plays an important role in the acquisition of new properties, such as pathogenicity and antibiotic resistance, and is therefore a driving force in "short-term" evolution, allowing bacteria to be masters of adaptation. The development of antibiotic resistant strains of bacteria is a major healthcare problem around the world and strains commonly become resistant by acquiring pre-existing resistance determinants from the bacterial gene pool. Mobile genetic elements play a central role in facilitating HGT and therefore promote the acquisition and spread of these resistance determinants. As such, bacterial populations can rapidly become resistant when exposed to an antimicrobial agent. Strains of Staphylococcus aureus "Golden Staph" are a major cause of hospital-acquired infections and most clinical strains contain multiple resistance plasmids. My research focuses on molecular mechanisms that contribute to the capacity of staphylococcal plasmids to acquire and maintain resistance genes in the absence of selective pressure.

研究领域

Bacterial evolution DNA segregation Genetic exchange Mobile elements Multiresistance plasmids Staphylococcus aureus

近期论文

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Almatroudi, A., Gosbell, I., Hu, H., Jensen, S., Espedido, B., Tahir, S., Glasbey, T., Legge, P., Whiteley, G. and [and two others], .. (2016), 'Staphylococcus aureus dry-surface biofilms are not killed by sodium hypochlorite : implications for infection control', Journal of Hospital Infection, vol 93, no 3 , pp 263 - 270. Malone, M., Gosbell, I., Dickson, H., Vickery, K., Espedido, B. and Jensen, S. (2016), '[In Press] Can molecular DNA-based techniques unravel the truth about diabetic foot infections?', Diabetes/Metabolism: Research and Reviews, . Brzoska, A., Jensen, S., Barton, D., Davies, D., Overall, R., Skurray, R. and Firth, N. (2016), 'Dynamic filament formation by a divergent bacterial actin-like ParM protein', PLoS One, vol 11, no 6 . Baines, S., Holt, K., Schultz, M., Seemann, T., Howden, B., Jensen, S., Van Hal, S., Coombs, G., Firth, N., Powell, D., Stinear, T. and Howden, B. (2015), 'Convergent adaptation in the dominant global hospital clone ST239 of methicillin-resistant Staphylococcus aureus', mBio, vol 6, no 2 . Espedido, B., Dimitrijovski, B., Hal, S. and Jensen, S. (2015), 'The use of whole-genome sequencing for molecular epidemiology and antimicrobial surveillance : identifying the role of IncX3 plasmids and the spread of blaNDM-4-like genes in the Enterobacteriaceae', Journal of Clinical Pathology, . Hu, H., Johani, K., Gosbell, I., Jacombs, A., Almatroudi, A., Whiteley, G., Deva, A., Jensen, S. and Vickery, K. (2015), 'Intensive care unit environmental surfaces are contaminated by multidrug-resistant bacteria in biofilms : combined results of conventional culture, pyrosequencing, scanning electron microscopy, and confocal laser microscopy', Journal of Hospital Infection, vol 91, no 1 , pp 35 - 44. Almatroudi, A., Hu, H., Deva, A., Gosbell, I., Jacombs, A., Jensen, S., Whiteley, G., Glasbey, T. and Vickery, K. (2015), 'A new dry-surface biofilm model : an essential tool for efficacy testing of hospital surface decontamination procedures', Journal of Microbiological Methods, vol 117 , pp 171 - 176. Espedido, B., Jensen, S. and Van Hal, S. (2015), 'Ceftaroline fosamil salvage therapy : an option for reduced-vancomycin-susceptible MRSA bacteraemia', Journal of Antimicrobial Chemotherapy, vol 70, no 3 , pp 797 - 801. Whiteley, G., Knight, J., Derry, C., Jensen, S., Vickery, K. and Gosbell, I. (2015), 'A pilot study into locating the bad bugs in a busy intensive care unit', American Journal of Infection Control, vol 43, no 12 , pp 1270 - 1275. Davis, R., Jensen, S., Hal, S., Espedido, B., Gordon, A., Farhat, R. and Chan, R. (2015), 'Whole genome sequencing in real-time investigation and management of a pseudomonas aeruginosa outbreak on a neonatal intensive care unit', Infection Control and Hospital Epidemiology, vol 36, no 9 , pp 1058 - 1064. Van Hal, S., Steen, J., Espedido, B., Grimmond, S., Cooper, M., Holden, M., Bentley, S., Gosbell, I. and Jensen, S. (2014), 'In vivo evolution of antimicrobial resistance in a series of Staphylococcus aureus patient isolates : the entire picture or a cautionary tale?', Journal of Antimicrobial Chemotherapy, vol 69, no 2 , pp 363 - 367. Espedido, B., Steen, J., Ziochos, H., Grimmond, S., Cooper, M., Gosbell, I., Van Hal, S. and Jensen, S. (2013), 'Whole genome sequence analysis of the first Australian OXA-48-producing outbreak-associated Klebsiella pneumoniae isolates : the resistome and in vivo evolution', PLoS ONE, vol 8, no 3 , pp 1 - 6. Liu, M., Kwong, S., Jensen, S., Brzoska, A. and Firth, N. (2013), 'Biology of the staphylococcal conjugative multiresistance plasmid pSK41', Plasmid, vol 70, no 1 , pp 42 - 51. Van Hal, S., Jensen, S., Vaska, V., Espedido, B., Paterson, D. and Gosbell, I. (2012), 'Predictors of mortality in Staphylococcus aureus bacteremia', Clinical Microbiology Reviews, vol 25, no 2 , pp 362 - 386. Espedido, B., Steen, J., Barbagiannakos, T., Mercer, J., Paterson, D., Grimmond, S., Cooper, M., Gosbell, I., Van Hal, S. and Jensen, S. (2012), 'Carriage of an ACME II variant may have contributed to methicillin- resistant Staphylococcus aureus sequence type 239-like strain replacement in Liverpool Hospital, Sydney, Australia', Antimicrobial Agents and Chemotherapy, vol 56, no 6 , pp 3380 - 3383. Liew, A., Theis, T., Jensen, S., Garcia-Lara, J., Foster, S., Firth, N., Lewis, P. and Harry, E. (2011), 'A simple plasmid-based system that allows rapid generation of tightly controlled gene expression in Staphylococcus aureus', Microbiology, vol 157, no 3 , pp 666 - 676. Shearer, J., Wireman, J., Hostetler, J., Forberg, H., Borman, J., Gill, J., Sanchez, S., Mankin, A., LaMarre, J., Lindsay, J., Bayles, K., Nicholson, A., O'Brien, F., Jensen, S., Firth, N., Skurray, R. and Summers, A. (2011), 'Major families of multiresistant plasmids from geographically and epidemiologically diverse Staphylococci', G3: Genes, Genomes, Genetics, vol 1, no 7 , pp 581 - 591. Kwong, S., Jensen, S. and Firth, N. (2010), 'Prevalence of Fst-like toxin-antitoxin systems', Microbiology, vol 156, no 4 , pp 975 - 977.