个人简介
徐凯林博士，为广东工业大学“青年百人计划”引进人才，广东工业大学制药工程系教师。任职于广东工业大学天然药物与绿色化学研究所、广东省药食同源综合利用与研究开发工程中心，Allan H. Conney新药研发联合实验室。近年来主要从事新型药剂学的研究，包括研究药物同质多晶、优势晶型、无定型、共晶及其药学性质等，重点在糖尿病药物优势晶型设计/控制策略的研发；新型抗癌组合疗法多功能复合纳米材料的设计研究；以及天然植物抗癌药物的发现和作用机制研究。迄今为止，已在包括Journal of cleaner production， International journal of pharmaceutics, CrystEngComm, Analyst, Journal of pharmaceutical and biomedical analysis，Journal of pharmaceutical sciences等一系列SCI期刊上发表学术论文三十余篇（其中第一作者或通讯作者发表SCI论文8篇）。
教育背景：
2014.09-2017.06：四川大学 制药工程专业 博士；
2011.09-2014.06：四川大学 制药工程专业 硕士；
2007.09-2011.06：怀化学院 制药工程专业 学士。
工作经历：
2017.07-至今：广东工业大学“青年百人”引进人才，制药工程系；
2018.03-2019.03：香港大学，李嘉诚医学院，访问学者。
教学活动：主要从事制药工程相关的专业课程，如《制药过程安全与环保》、《药物合成反应》、《制药工程专业实验》等课程的理论教学及实践教学。
我的团队：本团队隶属于“广工大绿色化学与天然药物研究所”、“广工大Allan Conney抗肿瘤药物实验室”以及“广东省药食同源植物资源开发与利用工程中心”。
研究领域
主要研究领域为新型药剂学：
1、药物固态形式多样化及其药学性质研究。包括研究药物同质多晶、无定型、共晶及其药学性质等，重点在糖尿病药物优势晶型设计/控制策略的研发；此研究可在不引入药物非活性成分的前提下弥补药物缺陷，获得优势新晶型，从原料药源头改善药物品质；
2、新型抗癌组合疗法多功能复合纳米材料的设计研究。基于肿瘤微环境的特点，设计逐级响应的抗癌组合疗法多功能复合纳米粒子，弥补化疗药物强烈的毒副作用弱点，利用现代新型组合技术实现精准靶向抗癌。
近期论文
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1. Jiewu Leng, Pingyu Jiang, Kailin Xu*, Qiang Liu, J. Leon Zhao, Yiyang Bian, Rui Shi. Makerchain: A blockchain with chemical signature for self-organizing process in social manufacturing [J]. Journal of Cleaner Production, 2019, 234, 767-778. (Ⅰ区, Top, IF=6.395, 通讯作者)
2. Xu Kailin, Zheng Shoujun, Zhai Yuanming, et al. Two solid forms of tauroursodeoxycholic acid and the effects of milling and storage temperature on solid-state transformations [J]. International journal of pharmaceutics, 2015, 486(1), 185-194. (II区, Top, IF=4.213, 第一作者)
3. Xu Kailin, Xiong Xinnuo, Li Shanshan, et al. New polymorph of glipizide with enhanced properties obtained using environmentally friendly methods [J]. CrystEngComm, 2016, 18, 4508–4512. (II区, IF=4.034, 第一作者)
4. Xu Kailin, Liang Bin, Li Yanfang, et al. Injection-ultrasound-assisted emulsification microextraction based on using low-density organic solvent followed by high-performance liquid chromatography for the determination of pyrethroids in water samples[J]. Analyst, 2013, 138(4), 1262-1270. (II区, IF= 4.019, 第一作者)
5. Xu Kailin, Xiong Xinnuo, Zhai Yuanming, et al. Effect of milling conditions on solid-state amorphization of glipizide, and characterization and stability of solid forms [J]. Journal of Pharmaceutical and Biomedical Analysis, 2016, 129: 367-377. (II区, IF= 3.169, 第一作者)
6. Xu Kailin, Zheng Shoujun, Guo Liuqi, et al. Four solid forms of tauroursodeoxycholic acid and solid-state transformations: effects of temperature and milling [J]. RSC Advances, 2015, 5(117), 96392-96403. (II区, IF= 3.840, 第一作者)
7. Xu Kailin, Xiong Xinnuo, Guo Liuqi, et al. An Investigation into the Polymorphism and Crystallization of Levetiracetam and the Stability of its Solid Form [J]. Journal of pharmaceutical sciences, 2015, 104(12), 4123-4131. (III区, IF= 3.007, 第一作者)
8. Xu Kailin, Liang Bin, Wu Xiaoqing, et al. X-ray powder diffraction data for levetiracetam [J]. Powder Diffraction, 2014, 29(01), 51-52. (IV区, IF= 0.586, 第一作者)
9. Xiao Yin, Xu Kailin, Wang Qing, et al. Synthesis, structure, and calf-thymus DNA binding of ternary fleroxacin–Cu (II) complexes[J]. RSC Advances, 2016, 6(83): 80286-80295.
10. Li Zhenzhen, Xu Kailin, Liang Bin, et al. Determination of trace tetracyclines in surface water by aluminum hydroxide coprecipitation coupled with high-performance liquid chromatography [J]. Analytical Methods, 2013, 5(14), 3516-3522.
11. Cheng Yuan, Xu Kailin, Li Hui, et al. Preparation of Urea-Imprinted Cross-Linked Chitosan and Its Adsorption Behavior [J]. Analytical Letters, 2014, 47(6), 1063-1078.
12. Li Xiangling, Xu Kailin, Li Hui, et al. Qualitative analysis of chiral alanine by UV-visible-shortwave near infrared diffuse reflectance spectroscopy combined with chemometrics [J]. RSC Advances, 2016, 6(10), 8395-8405.
13. Guo Liuqi, Xu Kailin, Ma Xiaoli, et al. X-ray powder diffraction data for niclosamide [J], Powder Diffraction, 2015, 30, 375-377.
14. Xiong Xinnuo, Xu Kailin, Li Shanshan, et al. Solid-state amorphization of rebamipide and investigation on solubility and stability of the amorphous form [J], Drug Development and Industrial Pharmacy, 2016, 1-10.
15. Xiong Xinnuo, Xu Kailin, Du Qiaohong, et al. Effects of Temperature and Solvent on the Solid-State Transformations of Pranlukast during Mechanical Milling [J], Journal of Pharmaceutical Sciences, 2017, doi 10.1016/j.xphs.2017.02.020.
16. Zou Huayu, Xu Kailin, Feng Yuyan, et al. Application of first order derivative UV spectrophotometry coupled with H-point standard addition to the simultaneous determination of melamine and dicyandiamide in milk[J]. Food analytical methods, 2015, 8(3), 740-748.
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