Nitschke, Jonathan - University of Cambridge

个人简介

Jonathan Nitschke was born in 1973 in Syracuse, New York. Following undergraduate studies (Williams College, MA) and graduate studies (Berkeley, CA) in the U.S., he undertook postdoctoral studies in France, and then started an independent research career at the University of Geneva (Switzerland). The Nitschke group moved to the University of Cambridge (United Kingdom) in 2007. Eduation and Experience Professor of Chemistry from October 2014 University Lecturer and Walters-Kundert Next Generation Fellow, Department of Chemistry, University of Cambridge, 2007 - 2011, then Reader 2011 - 2014 Maître-assistant, then Swiss National Science Foundation Assistant Professor, Department of Organic Chemistry, University of Geneva, August 2003 - October 2007 Postdoctoral Fellow with Jean-Marie Lehn, (US NSF Postdoctoral Fellowship), Université Louis Pasteur, Strasbourg, July 2001 - July 2003 Doctoral Student with T. Don Tilley, Department of Chemistry, University of California at Berkeley. PhD awarded May 2001 Undergraduate Student (Bachelor's Degree cum laude with Honors awarded June 1995), Williams College, Massachusetts, September 1991 - May 1995 Undergraduate NSF REU Researcher at SRI International, Menlo Park, California, summer 1994 Undergraduate Researcher at Nanoptics, Inc., Gainesville, Florida, summers 1992 and 1993

研究领域

Complex Architectures and Topology We have a keen interest in the formation of novel metal-organic architectures, particularly those with complex structures, which can allow a greater understanding of subcomponent self-assembly processes to be gained. The design principles developed from these studies provide a foundation for the design of metal-organic species to be used in more application-driven research such as phase transfer, host-guest chemistry and materials projects. Metallopolymers and Materials The metal-organic coordination motif can also be used in the design and synthesis of novel materials. We have demonstrated the formation of Cu(I)-containing helical metallopolymers with controllable length, regiochemistry, and luminescence. We have also used our metal-organic cages in the formation of gels and permanently porous liquids. Systems Chemistry and Chemistry Between Phases Systems chemistry deals with complex chemical systems that show properties that are not predictable solely from the individual components of the system. Our group has demonstrated functional out-of-equilibrium systems by developing a method by which a cage can reversibly rearrange during a time period when an added chemical “fuel” undergoes catalytic “burning.” Similarly, post-assembly modification cascade of a set of cages has led to their partitioning across phase boundaries. A triphasic sorting system has been developed in which three cages partitioned into three distinct solvent layers. Host-Guest Chemistry and Reactivity Metal-organic capsules often possess well-defined inner void spaces, within which the chemical reactivity and dynamics of guest molecules may be altered. We have used the selective guest encapsulation properties of these structures to trap and stabilize unstable species, separate substrates as diverse as gases and fullerenes, and as catalysts and sensors. In order to extend the range of applications of this class of synthetic receptors we have designed hosts that are capable of tightly and selectively binding large substrates and biologically relevant molecules.

近期论文

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Systematic construction of progressively larger capsules from a fivefold linking pyrrole-based subcomponent Kai Wu, Tanya K. Ronson, Pingru Su, Zhi Chen, Leonard Goh, Andrew W. Heard, Xiaopeng Li, Fabian Klautzsch, Christoph A. Schalley, Mladen Vinković & Jonathan R. Nitschke Nat. Synth., 2023 Light-Powered Reversible Guest Release and Uptake from Zn4L4 Capsules A. Ghosh, L. Slappendel, B.-N. T. Nguyen, L. K. S. von Krbek, T. K. Ronson, A. M. Castilla, and J. R. Nitschke J. Am. Chem. Soc. 2023, 145, 7, 3828–3832 Allosterically Regulated Guest Binding Determines Framework Symmetry for an FeII4L4 Cage W. Xue, K. Wu, N. Ouyang, T. Brotin, J. R. Nitschke Early View, 2023. Subtle Stereochemical Effects Influence Binding and Purification Abilities of an FeII4L4 Cage W. Xue, L. Pesce, A. Bellamkonda, T. K. Ronson, K. Wu, D. Zhang, N. Vanthuyne, T. Brotin, A. Martinez, G. M. Pavan, J. R. Nitschke J. Am. Chem. Soc. 2023, 145, 9, 5570–5577 A Double-Walled Tetrahedron with AgI4 Vertices Binds Different Guests in Distinct Sites S. E. Clark, A. W. Heard, C. T. McTernan, T. K. Ronson, B. Rossi, P. Rozhin, S. Marchesan, J. R. Nitschke Angew. Chem. Int. Ed., 2023, 62 (16), e202301612 Tetramine Aspect Ratio and Flexibility Determine Framework Symmetry for Zn8L6 Self-Assembled Structures J. A. Davies, A. Tarzia, T. K. Ronson, F. Auras, K. E. Jelfs, J. R. Nitschke. Angew. Chem. Int. Ed., 2023, e202217987. Enantioselective fullerene functionalization through stereochemical information transfer from a self-assembled cage Z. Lu, T. K. Ronson, A. W. Heard, S. Feldmann, N. Vanthuyne, A. Martinez, J. R. Nitschke. Nat. Chem., 2022, s41557-022-01103-y Host Spin‐Crossover Thermodynamics Indicate Guest Fit J. Zheng, L. K. S. von Krbek, T. K. Ronson, J. R. Nitschke. Angew. Chem. Int. Ed., 2022, 61, 50, e202212634. The fullerene awakens Z. Lu, A. W. Heard, J. R. Nitschke. Chem, 2022, 8, 11, 2907-2908. Supramolecular Self‐Assembly as a Tool to Preserve Electronic Purity of Perylene Diimide Chromophores I. Heckelmann, Z. Lu, J. C. A. Prentice, F. Auras, T. K. Ronson, R. H. Friend, J. R. Nitschke, S. Feldmann. Angew. Chem., e202216729 Incorporation of a Phosphino (pyridine) Subcomponent Enables the Formation of Cages with Homobimetallic and Heterobimetallic Vertices J. P. Carpenter, T. K. Ronson, F. J. Rizzuto, T. Héliot, P. Grice, J. R. Nitschke JACS, 2022, 144, 19, 8467-8473. Beyond Platonic: How to Build Metal–Organic Polyhedra Capable of Binding Low-Symmetry, Information-Rich Molecular Cargoes Charlie T. McTernan, Jack A. Davies, and Jonathan R. Nitschke Chem. Rev., 2022, 122, 11, 10393-10437 Solvent Drives Switching Between Λ and Δ Metal Center Stereochemistry of M8L6 Cubic Cages W. Xue, T. K. Ronson, Z. Lu, and J. R. Nitschke JACS, 2022, 144, 14, 6136–6142 Twisted rectangular subunits self-assemble into a ferritin-like capsule J.A. Davies, T.K. Ronson, J.R. Nitschke Chem. 2022, 8, 4, 1099-1106 Self-Assembly of Double Helical Metallopolymers J.L. Greenfield, J.R. Nitschke Acc. Chem. Res. 2022, 55, 391–401 Templation and Concentration Drive Conversion Between a FeII12L12 Pseudo-icosahedron, a FeII4L4 Tetrahedron, and a FeII2L3 Helicate D. Zhang, Q. Gan, A.J. Plajer, R. Lavendomme, T.K. Ronson, Z. Lu, J.D. Jensen, B.W. Laursen, J.R. Nitschke J. Am. Chem. Soc. 2022, 144, 1106–1112 Dynamic optimization of guest binding in a library of diastereomeric heteroleptic coordination cages Tanya K. Ronson, John P. Carpenter, and Jonathan R. Nitschke Chem, 2022, 8, 557-568 Deoxyribonucleic Acid Encoded and Size Defined π-Stacking of Perylene Diimides Jeffrey Gorman, Sarah R. E. Orsborne, Akshay Sridhar, Raj Pandya, Peter Budden, Alexander Ohmann, Naitik A. Panjwani, Yun Liu, Jake L. Greenfield, Simon Dowland, Victor Gray, Seán T. J. Ryan, Sara De Ornellas, Afaf El-Sagheer, Tom Brown, Jonathan R. Nitschke, Jan Behrends, Ulrich F. Keyser, Akshay Rao, Rosana Collepardo-Guevara, Eugen Stulz, Richard H. Friend, and Floria n Auras J. Am. Chem. Soc., 2022, 144, 368-376 FeII4L4 tetrahedron binds and aggregates DNA G-quadruplexes Jinbo Zhu, Zhiqiang Yan, Filip Bošković, Cally Jo Elizabeth Haynes, Marion Kieffer, Jake Greenfield, Jin Wang, Jonathan Nitschke, and Ulrich Keyser Chem. Sci., 2021, 12, 14564-14569 A Ravel Alliance Andrew W. Heard, Natasha M. A. Speakman, and Jonathan R. Nitschke Nat. Chem., 2021 Coordination Cages Selectively Transport Molecular Cargoes Across Liquid Membranes Bao-Nguyen T. Nguyen, John D. Thoburn, Angela B. Grommet, Duncan J. Howe, Tanya K. Ronson, Hugh P. Ryan, Jeanne L. Bolliger, Jonathan R. Nitschke J. Am. Chem. Soc., 2021, 143, 12175-12180 Cages meet gels: smart materials with dual porosity I. Jahović, Y.-Q Zou, S. Adorinni, J.R. Nitschke, S. Marchesan Matter, 2021, 4, 2123-2140 Sterics and Hydrogen Bonding Control Stereochemistry and Self-Sorting in BINOL-based Assemblies Y.-Q. Zou,‡ D. Zhang,‡ T.K. Ronson, A. Tarzia, Z. Lu, K.E. Jelfs, J.R. Nitschke J. Am. Chem. Soc., 2021, 143, 9009-9015. A curved host and second guest cooperatively inhibit the dynamic motion of corannulene Y. Yang, T.K. Ronson, Z. Lu, J. Zheng, N. Vanthuyne, A. Martinez, J.R. Nitschke Nature Commun. 2021, 12, 4079. A Cavity-Tailored Metal-Organic Cage Entraps Gases Selectively in Solution and the Amorphous Solid State J.-L. Zhu,‡ D. Zhang,‡ T.K. Ronson, W. Wang, L. Xu, H.-B. Yang and J.R. Nitschke Angew. Chem. Int. Ed. 2021, 60, 11789-11792. Electrically-induced mixed valence increases the conductivity of copper helical metallopolymers Jake L. Greenfield, Daniele Di Nuzzo, Emrys W. Evans, Satyaprasad P. Senanayak, Sam Schott, Jason T. Deacon, Adele Peugeot, William K. Myers, Henning Sirringhaus, Richard H. Friend, Jonathan R. Nitschke Adv. Mater. 2021, 2100403. Controlling the Shape and Chirality of an Eight-crossing Molecular Knot John P. Carpenter,‡ Charlie T. McTernan,‡ Jake L. Greenfield, Roy Lavendomme, Tanya K. Ronson and Jonathan R. Nitschke Chem 2021, 7, 1407-1409. Metal–organic cages for molecular separations Dawei Zhang , Tanya K. Ronson , You-Quan Zou and Jonathan R. Nitschke Nat. Rev. Chem., 2021, 5, 168-182. LaIII and ZnII Cooperatively Template a Metal-Organic Capsule Dong Yang, Jake L. Greenfield, Tanya K. Ronson, Larissa K. S. von Krbek, Le Yu, Jonathan R. Nitschke J. Am. Chem. Soc., 2020, 142, 19856-19861. Selective Anion Binding Drives the Formation of AgI8L6 and AgI12L6 Six-Stranded Helicates Charlie T. McTernan, Tanya K. Ronson, and Jonathan R. Nitschke J. Am. Chem. Soc., 2021, 143, 664-670. Glucose Binding Drives Reconfiguration of a Dynamic Library of Urea-Containing Metal-Organic Assemblies Dr. Dong Yang, Dr. Larissa K. S. von Krbek, Prof. Le Yu, Dr. Tanya K. Ronson, Prof. John D. Thoburn, Dr. John P. Carpenter, Dr. Jake L. Greenfield, Duncan J. Howe, Prof. Biao Wu and Prof. Jonathan R. Nitschke Angew. Chem. Int. Ed., 2020, 60, 4485-4490. Kinetics of toehold-mediated DNA strand displacement depends on FeII4L4 tetrahedron concentration Jinbo Zhu, Filip Bošković, Bao-Nguyen Thi, Jonathan Nitschke, Ulrich Keyser Nano Lett., 2021, 21, 1368-1374. Design and Applications of Water–Soluble Coordination Cages Edmundo G. Percástegui, Tanya K. Ronson, Jonathan R. Nitschke Chem. Rev., 2020, 24, 13480–13544. Engineering Permanent Porosity into Liquids Kecheng Jie, Yujuan Zhou, Hugh P. Ryan, Sheng Dai, Jonathan R. Nitschke Adv. Mater., 2021. Guest Encapsulation Within Surface-Adsorbed Self-Assembled Cages Hugh P. Ryan, Dr. Cally J. E. Haynes, Alyssa Smith, Dr. Angela B. Grommet, Prof. Jonathan R. Nitschke Adv. Mater., 2020, 33, 2004192. Hydrolysis of Twisted Amides inside a Self-Assembled Coordination Cage You-Quan Zou, Ilma Jahović, Jonathan R. Nitschke Chem 2020, 6, 1217-1218. An S10-Symmetric 5-Fold Interlocked [2]Catenane Tanya K. Ronson, Yujia Wang, Kim Baldridge*, Jay S. Siegel*, and Jonathan R. Nitschke*J. Am. Chem. Soc., 2020, 142, 10267–10272. Transformation Network Culminating in a Heteroleptic Cd6L6L 2 Twisted Trigonal Prism Dawei Zhang, Tanya K Ronson, Lin Xu*, and Jonathan R. Nitschke*J. Am. Chem. Soc., 2020, 142, 9152–9157. Narcissistic, integrative and kinetic self-sorting within a system of coordination cages Felix J. Rizzuto, Jonathan R. Nitschke J. Am. Chem. Soc., 2020, 142, 7749-7753. Guest Binding Drives Host Redistribution in Libraries of CoII4L4 Cages Marion Kieffer, Rana A. Bilbeisi, John D. Thoburn, Jack K. Clegg, Jonathan R. Nitschke Angew. Chem. Int. Ed. 2020, 59, 11369–11373. Heat Engine Drives Transport of an FeII4L4 Cage and Cargo Bao‐Nguyen T. Nguyen,‡ Angela B. Grommet,‡ Arnaud Tron, Maureen C. A. Georges, Jonathan R. Nitschke Adv. Mater., 2020, 32, 1907241. Improved Acid Resistance of a Metal-Organic Cage Enables Cargo Release and Exchange between Hosts Lin Xu,‡ Dawei Zhang,‡ Tanya K. Ronson, Jonathan R. Nitschke Angew. Chem. Int. Ed., 2020, 59, 77435-7438. Coordination cages as permanently porous ionic liquids Lillian Ma, Cally J. E. Haynes, Angela B. Grommet, Anna Walczak, Christopher C. Parkins, Cara M. Doherty, Louis Longley, Arnaud Tron, Artur R. Stefankiewicz, Thomas D. Bennett, Jonathan R. Nitschke Nat. Chem. 2020, 12, 270–275. Reversible Reduction Drives Anion Ejection and C60 Binding within a FeII4L6 Cage Zhenpin Lu, Tanya Ronson and Jonathan Nitschke Chem. Sci., 2020, 11, 1097-1101. Selective Separation of Polyaromatic Hydrocarbons by Phase Transfer of Coordination Cages Dawei Zhang, Tanya K. Ronson, Roy Lavendomme and Jonathan R. Nitschke J. Am. Chem. Soc., 2019, 141, 18949-18953. An antiaromatic-walled nanospace Masahiro Yamashina, Yuya Tanaka, Roy Lavendomme, Tanya K. Ronson, Michael Pittelkow and Jonathan R. Nitschke Nature, 2019, 74, 511-515. Temperature Controls Guest Uptake and Release from Zn4L4 Tetrahedra Dawei Zhang, Tanya K. Ronson, Songül Güryel, John D. Thoburn, David J. Wales and Jonathan R. Nitschke J. Am. Chem. Soc., 2019, 141, 14534-14538. FeII4L4 Tetrahedron Binds to Nonpaired DNA Bases Jinbo Zhu, Cally J. E. Haynes, Marion Kieffer, Jake L. Greenfield, Ryan D. Greenhalgh, Jonathan R. Nitschke and Ulrich F. Keyser J. Am. Chem. Soc., 2019, 141, 11358-11362. Anion Pairs Template a Trigonal Prism with Disilver Vertices John P. Carpenter,‡ Charlie T. McTernan,‡ Tanya K. Ronson, and Jonathan R. Nitschke J. Am. Chem. Soc., 2019, 141, 11409-11413. Ion‐Mobility Mass Spectrometry for the Rapid Determination of the Topology of Interlocked and Knotted Molecules Anneli Kruve, Kenji Caprice, Roy Lavendomme, Jan M. Wollschläger, Stefan Schoder, Hendrik V. Schröder, Jonathan R. Nitschke, Fabien B. L. Cougnon, Christoph A. Schalley Angew. Chem. Int. Ed., 2019, 58, 11324-11328. Different Modes of Anion Response Cause Circulatory Phase Transfer of a Coordination Cage with Controlled Directionality Nozomi Mihara, Tanya K. Ronson and Jonathan R. Nitschke Angew. Chem. Int. Ed., 2019, 131, 12627-12631. Metal and Organic Templates Together Control the Size of Covalent Macrocycles and Cages Roy Lavendomme, Tanya K. Ronson and Jonathan R. Nitschke J. Am. Chem. Soc., 2019, 141, 12147-12158. Multi-site binding of drugs and natural products in an entropically- favorable, heteroleptic receptor Felix J. Rizzuto, John P. Carpenter, and Jonathan R. Nitschke J. Am. Chem. Soc., 2019, 141, 9087-9095. A Zn4L6 capsule shows enhanced catalytic C‐C bond formation activity upon C60 binding Zhenpin Lu, Roy Lavendomme, Olaf Burghaus, Jonathan Nitschke Angew. Chem. Int. Ed., 2019, 58, 9073-9077. Enantiopure [Cs+/Xe⊂Cryptophane]⊂FeII4L4 Hierarchical Superstructures Dawei Zhang, Tanya K Ronson, Jake L. Greenfield, Thierry Britin, Patrick Berthault, Estelle Leonie, Junlong Zhu, Lin Xu, and Jonathan R. NItschke J. Am. Chem. Soc., 2019, 141, 8339-8345. Post-assembly Modification of Phosphine Cages Controls Host–Guest Behavior Charlie T. McTernan, Tanya K. Ronson, and Jonathan R. Nitschke J. Am. Chem. Soc., 2019, 141, 6837-6842. Strategies for binding multiple guests in metal–organic cages Felix J. Rizzuto, Larissa K. S. von Krbek, Jonathan R. Nitschke Nat. Rev. Chem., 2019, 3(4), 204–222. Embedding and positioning of two FeII4L4 cages in supramolecular tripeptide gels for selective chemical segregation Marion Kieffer, Ana M. Garcia, Cally J. E. Haynes, Slavko Kralj, Daniel Iglesias, Jonathan R. Nitschke and Silvia Marchesan Angew. Chem. Int. Ed., 2019, 58, 7982-7986. Fluorometric Recognition of Nucleotides within a Water‐Soluble Tetrahedral Capsule Alex J. Plajer, Dr. Edmundo G. Percástegui, Dr. Marco Santella, Dr. Felix J. Rizzuto, Dr. Quan Gan, Prof. Bo W. Laursen and Prof. Jonathan R. Nitschke Angew. Chem. Int. Ed., 2019, 58, 4068-4068. Waterproof architectures through subcomponent self-assembly Edmundo G. Percástegui, Jesús Mosquera, Tanya K. Ronson, Alex J. Plajer, Marion Kieffer and Jonathan R. Nitschke Chem. Sci., 2019, 10, 2006-2018. Hydrogen-bond-assisted symmetry breaking in a network of chiral metal- organic assemblies Felix J. Rizzuto, Patrick Pröhm, Alex J. Plajer, Jake L. Greenfield, and Jonathan R. Nitschke J. Am. Chem. Soc., 2019, 141, 1707-1715. Orthogonal Stimuli Trigger Self-Assembly and Phase Transfer of FeII4L4 Cages and Cargoes Anna J. McConnell, Cally J. E. Haynes, Angela B. Grommet, Catherine M. Aitchison, Julia Guilleme, Sigitus Mikutis and Jonathan R. Nitschke J. Am. Chem. Soc., 2018, 140, 16952-16956. Anion Exchange Drives Reversible Phase Transfer of Coordination Cages and Their Cargoes Angela B. Grommet, Jack B. Hoffman, Edmundo G. Percástegui, Jesús Mosquera, Duncan J. Howe, Jeanne L. Bolliger, and Jonathan R. Nitschke J. Am. Chem. Soc., 2018, 140, 14770-14776. Functional Capsules via Subcomponent Self-Assembly Dawei Zhang, Tanya K. Ronson, and Jonathan R. Nitschke Acc. Chem. Res., 2018, 51, 2423-2436. Multivalent Crown-ether Receptors Enable Allosteric Regulation of Anion Exchange in an Fe₄L₆ Tetrahedron Larissa K. S. von Krbek, Derrick A. Roberts, Ben S. Pilgrim, Christoph A. Schalley, Jonathan R. Nitschke Angew. Chem. Int. Ed., 2018, 57(43), 14121-14124. Otherwise unstable structures self-assemble in the cavities of cuboctahedral coordination cages Felix J. Rizzuto, William J. Ramsay, and Jonathan R. Nitschke J. Am. Chem. Soc., 2018, 140, 11502-11509. Post-Assembly Reactivity of N-Aryl Iminoboronates: Reversible Radical Coupling and Unusual B-N Dynamic Covalent Chemistry Evan N. Keyzer, Alexandru Sava, Tanya K. Ronson, Jonathan R. Nitschke and Anna J. McConnell Chem. Eur. J., 2018, 24, 12000-12005. Unravelling Mechanisms of Chiral Induction in Double-Helical Metallopolymers Jake L Greenfield, Emrys W. Evans, Daniele Di Nuzzo, Marco Di Antonio, Richard H. Friend, and Jonathan R. Nitschke J. Am. Chem. Soc., 2018, 140, 10344-10353. Covalent post-assembly modification triggers multiple structural transformations of a tetrazine-edged FeII₄L₆ tetrahedron Derrick A. Roberts, Ben S. Pilgrim, Giedre Sirvinskaite, Tanya K Ronson, and Jonathan R. Nitschke J. Am. Chem. Soc., 2018, 140, 9616-9623 Selective Anion Extraction and Recovery Using a FeII4L4 Cage Dawei Zhang, Tanya K. Ronson, Jesus Mosquera, Alexandre Martinez, and Jonathan R. Nitschke Angew. Chem. Int. Ed., 2018, 57, 3717-3721. A giant M2L3 metallo-organic helicate based on phthalocyanines as a host for electroactive molecules Ettore Fazio, Cally J. E. Haynes, Gema de la Torre, Jonathan R. Nitschke and Tomás Torres. Chem. Commun., 2018, 54, 2651–2654. Quantified structural speciation in CoII6L4 cage systems Felix J. Rizzuto, Marion Kieffer and Jonathan R. Nitschke. Chem. Sci., 2018, 9, 1925-1930. Covalent post-assembly modification in metallosupramolecular chemistry Derrick A. Roberts, Ben S. Pilgrim and Jonathan R. Nitschke. Chem. Soc. Rev., 2018, 47, 626-644