吴成君 - 大连理工大学 - 生物医学工程学院

个人简介

吴成君，博士毕业于清华大学医学部&北京协和医学院。2010年6月至2015年2月在瑞典乌普萨拉大学生物医学中心分别从事博士后和科研教学工作。2015年3月开始受聘于隆德大学生物医学中心，研究员，从事科研教学，并于2017年3月获得终身教职。2019年3月作为海外引进人才入职大连理工大学生物医学工程学院，教授职称，博导教育经历 2005.92009.7 清华大学北京协和医学院病原生物学博士工作经历 2019.3至今大连理工大学电信学部

研究领域

从事与头颈癌和女性宫颈癌发生相关的人乳头瘤病毒（HPV, Human Papilloma Virus）细胞与分子生物研究。主要从表观遗传学的角度研究HPV16诱发细胞癌变的分子机制以及抗肿瘤小分子药物的筛选

近期论文

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1. Chengjun Wu, Kersti Nilsson, Yunji Zheng, Camilla Ekenstierna, Natsuki Sugiyama, OlaForslund, Naoko Kajitani, Haoran Yu, Johan Wennerberg, Lars Ekblad, Stefan Schwarts. Short half-life of HPV16 E6 and E7 mRNAs sensitizes HPV16-positive tonsillar cancer cellsto DNA-damaging drugs. International Journal of Cancer 2019，144（4）：297-310 IF: 7.36 2. Ola Forslund, Natsuki Sugiyama, Chengjun Wu, Naveen Ravi, Yuesheng Jin, Sabine Swoboda, Fredrik Andersson, Davit Bzhalava, Emilie Hultin, Kajsa Paulsson, Joakim Dillner, Stefan Schwartz, Johan Wennerberg, Lars Ekblad A novel human in vitro papillomavirus type 16 positive tonsil cancer cell line with high sensitivity to radiation and cisplatin BMC Cancer 2019 Mar 25;19(1):265. IF: 3.28 3. Kersti Nilsson#, Chengjun Wu# 1, Kajitani N., Glahder, J., Haoran Yu, Schwartz1, S.The DNA damage response can induce HPV16 late gene expression by inhibiting theHPV16 early polyadenylation signal and Activating HPV16 late splice sites Nuclear Acid Research 2018 Jun 1;46(10):5029-5049 （并列一作和通讯作者） IF: 11.56 4. Haoran Yu, Chengjun Wu*, Kersti Nilsson, Naoko Kajitani, Stefan Schwartz*Adenosine causes read-through into the late region of the HPV16 genome in a guanosine dependent manner Virology 2018 Jun 1;521:1-19. (共同通讯作者) IF: 3.37 5. Chengjun Wu, Kajitani N., Stefan Schwart Splicing and polyadenylation of human papillomavirus type 16 mRNAS. International Journal of Molecular Sciences 2017 Feb 9;18(2) IF: 3.68 6. Chengjun Wu, Xiaofang Cao, Di Yu, Elisabeth J. M. Huijbers, Magnus Essand, Göran Akusjärvi, Staffan Johansson, Cathrina Svensson HAdV-2 suppressed growth of SV40 T antigen transformed mouse mammary epithelial cell-induced tumours in SCID mice. Virology. 2015 18;489:44 IF: 3.37 7.Chengjun Wu, Lufeng Bai, Zhiqun Li, Charles E. Samuel, Göran Akusjärvi and Catharina Svensson Poor growth of human adenovirus-12 compared to adenovirus-2 correlates with a failure to impair PKR activation during the late phase of infection. Virology 2015 15;475:120-128. IF: 3.37 8. Li Guo*, Chengjun Wu*, Hongli Zhou, Chao Wu, Glaucia Paranhos-Bacala, Guy Vemet, Qi Jin, Jianwei Wang, Tao Hung Identification of DNA-binding protein (DBP), a nonstructural protein, as an immunogen with diagnostic potential in human. Co-first author Plos One 2013 8:e56708 IF: 3.53 9. Chengjun Wu, Daniel Öberg, Asif Rashid, Rajesh Gupta, StaffanJohansson, Göran Akusjärvi and Catharina Svensson A mouse mammary epithelial cell line permissive for highly efficient human adenovirus growth. Virology 2013 20:363-371 IF: 3.37 10. Chenjun Wu, Xiaobo Lei, Jianwei Wang, Tao Hung Generation of a replication deficient recombinant human adenovirus type 35 vector using bacterial-mediated homologous recombination J. Virol. Methods 2012（177）: 55-63. IF: 1.91