Procter, David - The University of Manchester

个人简介

David John Procter was born in Leyland in Lancashire, England. He obtained his BSc in Chemistry from the University of Leeds in 1992 and his PhD in 1995 working with Professor Christopher Rayner on the asymmetric oxidation of sulfides with novel selenoxide salts. He then spent two years as a postdoctoral research associate with Professor Robert Holton at Florida State University in Tallahassee, USA working on the synthesis of analogues of the anticancer agent Taxol. In late 1997 he took up a Lectureship at the University of Glasgow in Scotland and was promoted to Senior Lecturer in February 2004. In September 2004, he moved to a Readership at the University of Manchester. David was promoted to Professor in October 2008. His research interests lie in the development of new synthetic methods, target synthesis, and catalysis. EPSRC Established Career Fellowship (2015-2020) Author profile in Angewandte Chemie (Angew. Chem. Int. Ed. 2017, 56, 5152) 2014 Bader Prize from the Royal Society of Chemistry (Highlight in Angewandte: AUG 2014; DOI: 10.1002/anie.201407224) 2014 Liebig Lectureship from the German Chemical Society (Highlight in Angewandte: DEC 2014; DOI: 10.1002/anie.201410394) Leverhulme Trust Research Fellow (2013-2014) 2015 RSC Heterocyclic & Synthesis Group, Young Heterocyclic Chemist Award Lecture Lead author, "Organic Synthesis using Samarium Diiodide: A practical guide", RSC, ISBN (print): 978-1-84755-110-8

研究领域

David has introduced new strategies for the efficient construction of organic molecules with important properties. For example, he has completed the total synthesis of challenging natural architectures using new cyclizations developed in his team (incl. the antibacterial pleuromutilin), prepared novel organic materials using his new methods, developed copper-catalyzed multicomponent couplings, and invented metal-free coupling processes that lessen our reliance on expensive and supply-risk late transition metals. Much of his work has been carried out in collaboration with Industry (30 grants from Industry) and with academic teams in theoretical, physical organic, and materials chemistry and in physics and biology.

近期论文

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Biocatalytic Activation of Sulfur Heteroaromatics Facilitates Dearomatizing Cross-Couplings to Set Stereogenic Centers or Axes Conboy, Ó., Rushworth, E. Q., Taylor, C. J., Levy, C. W., Ortmayer, M., Whitehead, G. F. S., Yen, A., Romano, C., Green, A. P. & Procter, D. J., 4 Nov 2025, (E-pub ahead of print) In: Journal of the American Chemical Society. Contemporary Strategies in SmI2 Catalysis: A Reagent Reborn Mansell, J., Romano, C. & Procter, D., 13 Oct 2025, In: Angewandte Chemie. International Edition. e202519678. SmI2-Catalyzed Coupling of Alkyl Housane Ketones and Alkenes in an Approach to Norbornanes Procter, D., Roy, D., Mansell, J., Yu, S., Kaltsoyannis, N., Barison, G. & Romano, C., 8 Jul 2025, In: Angewandte Chemie. International Edition. 64, e202512018. A blueprint for catalysis Mansell, J., Procter, D. & Romano, C., 6 Mar 2024, In: Nature Catalysis. 16, 3, 1 p. Alkyl Cyclopropyl Ketones in Catalytic Formal [3 + 2] Cycloadditions: The Role of SmI2 Catalyst Stabilization Mansell, J., Procter, D. (Corresponding), Pye, E., Beltran, F., Kaltsoyannis, N., Yu, S., Romano, C., Rossi-Ashton, J. & Li, M., 8 May 2024, In: Journal of the American Chemical Society. 146, 18, p. 12799-12807 9 p. Aryl sulfonium salt electron donor-acceptor complexes for halogen atom transfer: Isocyanides as tunable coupling partners Zhao, H., Cuomo, V., Rossi-Ashton, J. & Procter, D., 11 Apr 2024, In: Chem. 10, 4, p. 1240-1251 11 p. Computational Study of SmI2‑Catalyzed Intermolecular Couplings of Cyclopropyl Ketones: Links between the Structure and Reactivity Yu, S., Romano, C., Procter, D. & Kaltsoyannis, N., 22 Oct 2024, In: Journal of Organic Chemistry. 89, p. 15842-15850 Flavin-Mediated Photocatalysis Provides a General Platform for Sulfide C–H Functionalization Anderton, A. S., Knowles, O. J., Rossi-Ashton, J. A. & Procter, D. J., 16 Feb 2024, In: ACS Catalysis . 14, 4, p. 2395-2401 7 p. A catalytic alkene insertion approach to bicyclo[2.1.1]hexane bioisosteres Agasti, S., Beltran, F., Pye, E., Kaltsoyannis, N., Crisenza, G. E. M. & Procter, D. J., 1 Apr 2023, In: Nature Chemistry. 15, 4, p. 535-541 7 p. A general arene C–H functionalization strategy via electron donor–acceptor complex photoactivation Dewanji, A., van Dalsen, L., Rossi-Ashton, J. A., Gasson, E., Crisenza, G. E. M. & Procter, D., Jan 2023, In: Nature Chemistry. Metal-Free Arylation of Benzothiophenes at C4 by Activation as their Benzothiophene S-Oxides Crisenza, G., Procter, D., Bisht, R., He, Z., Muhammad Ibrahim, A., Popescu, M. & Paton, R. S., 2023, In: Angewandte Chemie. International Edition. 62 Sulfonium Salts as Acceptors in Electron Donor-Acceptor Complexes Brown, R., Van Dalsen, L., Procter, D. & Rossi-Ashton, J., 23 Mar 2023, In: Angewandte Chemie. International Edition. Asymmetric Total Synthesis of (−)-Phaeocaulisin A Péter, Á., Crisenza, G. E. M. & Procter, D. J., 27 Apr 2022, In: Journal of the American Chemical Society. 144, 16, p. 7457−7464 8 p. A Vitamin B2-Photocatalysed Approach to Methionine Analogues Knowles, O. J., Johannissen, L. O., Crisenza, G. E. M., Hay, S., Leys, D. & Procter, D. J., 5 Dec 2022, In: Angewandte Chemie. International Edition. 61, 50 Diastereoselective radical 1,4-ester migration: radical cyclizations of acyclic esters with SmI2 Morrill, C., Péter, Á., Amalina, I., Pye, E., Crisenza, G., Kaltsoyannis, N. & Procter, D., 3 Aug 2022, In: Journal of the American Chemical Society. 144, 30, p. 13946-13952 7 p. Modular synthesis of unsymmetrical [1]benzothieno[3,2-b][1]benzothiophene molecular semiconductors for organic transistors Tayu, M., Rahmanudin, A., Perry, G. J. P., Khan, R. U., Tate, D. J., Marcial-Hernandez, R., Shen, Y., Dierking, I., Janpatompong, Y., Aphichatpanichakul, S., Zamhuri, A., Victoria-Yrezabal, I., Turner, M. L. & Procter, D. J., 5 Jan 2022, In: Chemical Science. 13, 2, p. 421-429 9 p. Inhibitors of the Bub1 spindle assembly checkpoint kinase: synthesis of BAY-320 and comparison with 2OH-BNPP1 Amalina, I., Bennett, A., Whalley, H., Perera, D., McGrail, J. C., Tighe, A., Procter, D. J. & Taylor, S. S., 15 Dec 2021, In: Royal Society Open Science. 8, 12, p. 210854 Modular synthesis of stereodefined benzocyclobutene derivatives via sequential Cu- and Pd-catalysis Talbot, F., Zhang, S., Satpathi, B., Howell, G., Perry, G., Crisenza, G. & Procter, D., 3 Dec 2021, In: ACS Catalysis. Needles from haystacks: single‐scan selective excitation of individual NMR signals in overlapping multiplets Kiraly, P., Kern, N., Plesniak, M., Nilsson, M., Procter, D., Morris, G. & Adams, R., 11 Jan 2021, In: Angewandte Chemie International Edition. 60, 2, p. 666-669 4 p. Recent advances in the chemistry of ketyl radicals Péter, Á., Agasti, S., Knowles, O., Pye, E. & Procter, D., 23 Mar 2021, In: Chemical Society Reviews. 50, 9, p. 5349-5365 17 p. SmI2-catalyzed intermolecular couplings by radical relay Agasti, S., Procter, D. & Crisenza, G., 24 Jul 2021, In: Trends in Chemistry. 3, 11, p. 982-983 Cascades, Catalysis and Chiral Ligand Control with SmI2; The Rebirth of a Reagent Péter, Á. & Procter, D. (Lead), 1 Feb 2020, In: Chimia. 74, 1, p. 18-22 5 p. Copper‐Catalyzed Borylative Couplings with C–N Electrophiles Talbot, F., Dherbassy, Q., Manna, S., Shi, C., Zhang, S., Howell, G. P., Perry, G. & Procter, D. J., 2020, In: Angewandte Chemie International Edition. Enantio- and Diastereoselective Synthesis of Homopropargyl Amines by Copper-Catalyzed Coupling of Imines, 1,3-Enynes, and Diborons Manna, S., Dherbassy, Q., Perry, G. J. P. & Procter, D. J., 2020, In: Angewandte Chemie International Edition. Metal-Free Photoredox-Catalyzed, Formal C–H/C–H Coupling of Arenes Enabled by Interrupted Pummerer Activation Aukland, M., Siauciulis, M., West, A., Perry, G. & Procter, D., 2020, In: Nature Catalysis. 3, p. 163-169 7 p. Radical C–C bond formation using sulfonium salts and light Péter, Á., Perry, G. & Procter, D. (Lead), 2020, In: Advanced Synthesis and Catalysis. Samarium Diiodide Catalyzed Radical Cascade Cyclizations that Construct Quaternary Stereocenters Huang, H. M., He, Q. & Procter, D. J., 2020, In: SYNLETT. 31, 1, p. 45-50 6 p. Sulfoxide-mediated oxidative cross-coupling of phenols He, Z., Perry, G. J. P. & Procter, D. J., 2020, In: Chemical Science. Trifluoromethyl sulfoxides: New reagents for metal‐free C–H trifluoromethylthiolation Wang, D., Carlton, C. G., Tayu, M., Mcdouall, J. J. W., Perry, G. J. P. & Procter, D. J., 2020, In: Angewandte Chemie International Edition. Copper-catalyzed borylative multi-component synthesis of quaternary α-amino esters Yeung, K., Talbot, F., Howell, G. P., Pulis, A. P. & Procter, D. J., 2019, In: ACS Catalysis. Enantioselective and Regioselective Copper-Catalyzed Borocyanation of 1-Aryl-1,3-Butadienes Jia, T., Smith, M. J., Pulis, A. P., Perry, G. J. P. & Procter, D. J., 2019, In: ACS Catalysis. p. 6744-6750 Heterologous production, reconstitution and EPR spectroscopic analysis of prFMN dependent enzymes Marshall, S. A., Payne, K. A. P., Fisher, K., Gahloth, D., Bailey, S. S., Balaikaite, A., Saaret, A., Gostimskaya, I., Aleku, G., Huang, H., Rigby, S. E. J., Procter, D. & Leys, D., 2019, Methods in Enzymology. Vol. 620. p. 489-508 20 p. (Methods in Enzymology). Metal-free synthesis of benzothiophenes via 2-fold C-H functionalization: direct access to materials-oriented heteroaromatics Yan, J., Pulis, A. P., Perry, G. J. P. & Procter, D. J., 2019, In: Angewandte Chemie International Edition. Pummerer chemistry of benzothiophene S-oxides: Metal-free alkylation and arylation of benzothiophenes Perry, G., Procter, D., He, Z. & Pulis, A., 3 Jul 2019, In: Phosphorus, Sulfur and Silicon and Related Elements. SmI2-catalyzed cyclization cascades by radical relay Huang, H.-M., McDouall, J. J. W. & Procter, D., 28 Jan 2019, In: Nature Catalysis. 2, 3, p. 211-218 8 p. The Interrupted Pummerer Reaction in a Sulfoxide-Catalyzed Oxidative Coupling of 2-Naphthols He, Z., Pulis, A. P. & Procter, D. J., 8 Apr 2019, In: Angewandte Chemie - International Edition. Transition‐Metal‐Free Cross‐Coupling of Benzothiophenes and Styrenes in a Stereoselective Synthesis of Substituted (E,Z)‐1,3‐Dienes Siauciulis, M., Ahlsten, N., Pulis, A. & Procter, D., 13 Jun 2019, In: Angewandte Chemie. International Edition. 58, 26, p. 8779-8783 An Interrupted Pummerer/Nickel-Catalysed Cross-Coupling Sequence Aukland, M. H., Talbot, F. J. T., Fernández-salas, J. A., Ball, M., Pulis, A. P. & Procter, D. J., 26 Jul 2018, In: Angewandte Chemie International Edition. 57, 31 Biocatalytic conversion of cyclic ketones bearing α-quaternary stereocenters to lactones in an enantioselective radical approach to medium-sized carbocycles Morrill, C., Jensen, C., Just-Baringo, X., Grogan, G., Turner, N. & Procter, D., 26 Mar 2018, In: Angewandte Chemie - International Edition. 57, 14, p. 3692-3696 4 p. Radical Anions from Urea-type Carbonyls: Radical Cyclizations and Cyclization Cascades Huang, H., McDouall, J. J. W. & Procter, D., 17 Apr 2018, In: Angewandte Chemie. 57, 18, p. 4995-4999 5 p. Reductive cyclisations of amidines involving aminal radicals Huang, H.-M., Adams, R. W. & Procter, D. J., 2018, In: Chemical Communications. 54, 72, p. 10160-10163 Regiodivergent copper catalyzed borocyanation of 1,3-dienes Jia, T., He, Q., Ruscoe, R. E., Pulis, A. & Procter, D. J., 27 Aug 2018, In: Angewandte Chemie International Edition. 57, 35 Samarium(II) folding cascades involving hydrogen atom transfer for the synthesis of complex polycycles Plesniak, M., Garduno Castro, M. H., Lenz, P., Just-Baringo, X. & Procter, D., 15 Nov 2018, In: Nature Communications. 9, 4802. Selective Electron Transfer Reduction of Urea-Type Carbonyls Huang, H.-M. & Procter, D. J., 20 Aug 2018, In: European Journal of Organic Chemistry. Synthesis of C2 Substituted Benzothiophenes via an Interrupted Pummerer/[3,3]-Sigmatropic/1,2-Migration Cascade of Benzothiophene S-Oxides He, Z., Shrives, H., Fernandez-Salas, J. A., Abengozar, A., Neufeld, J., Yang, K., Pulis, A. & Procter, D., 2018, In: Angewandte Chemie. Transition-Metal-Free Synthesis of C3-Arylated Benzofurans from Benzothiophenes and Phenols Yang, K., Pulis, A. P., Perry, G. J. P. & Procter, D. J., 7 Dec 2018, In: Organic Letters. 20, 23, p. 7498-7503