个人简介

Dr. Kuriyan is also Chancellor's Professor at the University of California, Berkeley. He received a B.S. degree in chemistry from Juniata College, Pennsylvania, and a Ph.D. degree from the Massachusetts Institute of Technology, where he worked with Gregory Petsko and Martin Karplus (Harvard University) on the dynamics of proteins. He continued with Martin Karplus and Greg Petsko for a year and then moved to Rockefeller as Assistant Professor and University Fellow. Dr. Kuriyan is a member of the National Academy of Sciences.

研究领域

Structural Biology of Cellular Signal Transduction and DNA Replication John Kuriyan is interested in the construction, mechanism, and regulation of the molecular machines and switching devices that carry out signal transduction and DNA replication. His laboratory uses x-ray crystallography to determine the three-dimensional structures of the component proteins, along with biochemical and biophysical analyses to elucidate mechanisms.

Structural Biology of Cellular Signal Transduction and DNA Replication John Kuriyan is interested in the construction, mechanism, and regulation of the molecular machines and switching devices that carry out signal transduction and DNA replication. His laboratory uses x-ray crystallography to determine the three-dimensional structures of the component proteins, along with biochemical and biophysical analyses to elucidate mechanisms

近期论文

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Identification of inhibitors of the association of ZAP-70 with the T cell receptor by high-throughput screen Patrick R. Visperas, Christopher G. Wilson, Jonathan A. Winger, Qingrong Yan, Kevin Lin, Michelle R. Arkin, Arthur Weiss and John Kuriyan SLAS Discov. 2017 Mar 1;22(3):324-331. doi: 10.1177/1087057116681407. Epub 2016 Dec 13 An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor Neel H. Shah, Qi Wang, Qingrong Yan, Deepti Karandur, Theresa A. Kadlecek, Ian R. Fallahee, William P. Russ, Rama Ranganathan, Arthur Weiss and John Kuriyan eLife 2016 Oct 4;5:e20105. doi: 10.7554/eLife.20105 Molecular basis for multimerization in the activation of the epidermal growth factor receptor Yongjian Huang*, Shashank Bharill*, Deepti Karandur, Sean M. Peterson, Morgan Marita, Xiaojun Shi, Megan J. Kaliszewski, Adam W. Smith, Ehud Y. Isacoff and John Kuriyan eLife 2016 Mar 28;5:e14107. doi: 10.7554/eLife.14107. Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II Moitrayee Bhattacharyya*, Margaret M. Stratton*, Catherine C. Going*, Ethan McSpadden, Yongjian Huang, Anna C. Susa, Anna Elleman, Yumeng Melody Cao, Nishant Pappireddi, Pawel Burkhardt, Christine L. Gee, Tiago Barros, Howard Schulman, Evan R. Williams and John Kuriyan eLife 2016 Mar 7;5:e13405. doi: 10.7554/eLife.13405. Crystal Structure of a Ube2S-Ubiquitin Conjugate Sonya Lorenz, Moitrayee Bhattacharyya, Christian Feiler, Michael Rape and John Kuriyan PLoS One 2016 Feb 1;11(2):e0147550. doi: 10.1371/journal.pone.0147550 Crystal structure of the FLT3 kinase domain bound to the inhibitor Quizartinib (AC220) Julie A. Zorn, Qi Wang, Eric Fujimura, Tiago Barros and John Kuriyan PLoS One 2015 Apr 2;10(4):e0121177. doi: 10.1371/journal.pone.0121177 Analysis of the role of the C-terminal tail in the regulation of the epidermal growth factor receptor Erika Kovacs*, Rahul Das*, Qi Wang, Timothy S. Collier, Aaron Cantor, Yongjian Huang, Kathryn Wong, Amar Mirza, Tiago Barros, Patricia Grob, Natalia Jura, Ron Bose and John Kuriyan Mol Cell Biol. 2015 Sep 1;35(17):3083-102. doi: 10.1128/MCB.00248-15. Epub 2015 Jun 29. Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity Sonja Lorenz, Patricia Deng, Oliver Hantschel, Giulio Superti-Furga and John Kuriyan Biochem. J. 2015, Jun 1;468(2):283-91 doi:10.1042/BJ20141492 Wang et al 2015 Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate Qi Wang, Erik M Vogan, Laura M Nocka, Connor E Rosen, Julie A Zorn, Stephen C Harrison and John Kuriyan eLife 2015 10.7554/eLife.06074 Visperas et al 2015 Modification by covalent reaction or oxidation of cysteine residues in the Tandem-SH2 Domains of ZAP-70 and Syk Can Block Phosphopeptide Binding Patrick R. Visperas, Jonathan A. Winger, Timothy M. Horton, Neel H. Shah, Diane J. Aum, Alyssa Tao, Tiago Barros, Qingrong Yan, Christopher G. Wilson, Michelle R. Arkin, Arthur Weiss and John Kuriyan Biochem J. 2015;465(1):149-61 2014 Stratton et al 2014 Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity Margaret Stratton, Il-Hyung Lee, Moitrayee Bhattacharyya, Sune M Christensen, Luke H Chao, Howard Schulman, Jay T Groves and John Kuriyan eLife 2013 Jan 1;3:e01610. doi: 10.7554/eLife.01610 2013 Iwig et al 2013 Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1 Jeffrey S. Iwig, Yvonne Vercoulen, Rahul Das, Tiago Barros, Andre Limnander, Yan Che, Jeffrey G. Pelton, David E. Wemmer, Jeroen P. Roose and John Kuriyan eLife 2013 Jul 30;2:e00813. doi: 10.7554/eLife.00813 Barros et al 2013 Barros et al 2013 A structural role for the PHP domain in E. coli DNA polymerase III Tiago Barros*, Joel Guenther*, Brian Kelch, Jordan Anaya, Arjun Prabhakar, Mike O'Donnell, John Kuriyan and Meindert H. Lamers BMC Struct Biol. 2013 May 14;13:8. doi: 10.1186/1472-6807-13-8 Engel et al 2013 A highly efficient peptide substrate for EGFR activates the kinase by inducing aggregation Kate Engel, Tomoaki Sasaki, Qi Wang and John Kuriyan Biochem J. 2013 Aug 1;453(3):337-44. doi: 10.1042/BJ20130537 Yan et al 2013 Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker Qingrong Yan, Tiago Barros, Patrick R. Visperas, Sebastian Deindl, Theresa A. Kadlecek, Arthur Weiss and John Kuriyan Mol Cell Biol. 2013 Jun;33(11):2188-201. doi: 10.1128/MCB.01637-12 Endres et al 2013 Endres et al 2013 Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor Nicholas F. Endres*, Rahul Das*, Adam W. Smith*, Anton Arkhipov, Erika Kovacs, Yongjian Huang, Jeffrey G. Pelton, Yibing Shan, David E. Shaw, David E. Wemmer, Jay T. Groves and John Kuriyan Cell 2013 Jan 31;152(3):543-56. doi: 10.1016/j.cell.2012 2011 Kelch et al 2011 Kelch et al 2011 How a DNA polymerase clamp loader opens a sliding clamp Brian A. Kelch*, Debora L. Makino*, Michael O'Donnell and John Kuriyan Science 2011 Dec 23;334(6063):1675-80. doi: 10.1126/science.1211884 Chao et al 2011 A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin-dependent kinase II holoenzyme Luke H. Chao, Margaret M. Stratton, Il-Hyung Lee, Oren S. Rosenberg, Joshua Levitz, Daniel J. Mandell, Tanja Kortemme, Jay T. Groves, Howard Schulman and John Kuriyan Cell 2011 Sep 2;146(5):732-45. doi: 10.1016/j.cell.2011.07.038 Lorenz et al 2011 The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2 Katherine E Wickliffe*, Sonja Lorenz*, David E. Wemmer, John Kuriyan and Michael Rape Cell 2011 Mar 4;144(5):769-81. doi: 10.1016/j.cell.2011.01.035 2010 Chao et al 2010 Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation Luke H Chao, Patricia Pellicena, Sebastian Deindl, Lauren A Barclay, Howard Schulman and John Kuriyan Nat Struct Mol Biol. 2010 Mar;17(3):264-72. doi: 10.1038/nsmb.1751 Gureasko et al 2010 Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless Jodi Gureasko, Olga Kuchment, Debora Lika Makino, Holger Sondermann, Dafna Bar-Sagi and John Kuriyan Proc Natl Acad Sci U S A.2010 Feb 23;107(8):3430-5. doi: 10.1073/pnas.0913915107 McNally et al 2010 Analysis of the role of PCNA-DNA contacts during clamp loading Randall McNally, Gregory D Bowman, Eric R Goedken, Mike O'Donnell and John Kuriyan BMC Struct. Biol.2010 Jan 30;10:3. doi: 10.1186/1472-6807-10-3 2009 Jura et al 2009