个人简介

Dec. 2011 Prof. (W2) at Technische Universität München 2009 - 2011 Project group leader at the Max Planck Institute of Molecular Physiology, Dortmund 2007 - 2008 PostDoc Max Planck Institute of Molecular Physiology, Dortmund 2003 - 2007 Dissertation Chemistry Max Planck Institute of Molecular Physiology, Dortmund and Technische Universität Dortmund 2003 Diploma in Biochemistry 1997 - 2002 Study of Biochemistry University Hannover

研究领域

Organic Chemistry and Biochemistry

Our research is concerned with the biochemical and proteinchemical preparation of modified proteins that enable us to yield molecular insights into the regulation of cellular processes. Here, the application and investigation of enzymes from Legionella bacteria is of great interest to us, since these pathogens have evolved intriguing ways to selectively modify proteins and thereby obtain control over specific signaling pathways the host cell. These interesting enzymes and the protein modifications mediated by them provide means to analyze the molecular aspects of intracellular transport processes.

近期论文

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Dolinsky S., Haneburger I., Cichy A., Hannemann M., Itzen A., Hilbi H. The Legionella longbeachae Icm/Dot substrate SidC selectively binds PtdIns(4)P with nanomolar affinity and promotes pathogen vacuole-ER interactions. Infection and Immunity 82:4021-4033 Yin G., Lopes da Fonseca T., Eisbach S.E., Anduaga A.M., Breda C., Orcellet M.L., Szegő E.M., Guerreiro P., Lazaro D., Braus G.H., Fernandez C.O., Griesinger C., Becker S., Goody R.S., Itzen A., Giorgini F., Outeiro T.F., Zweckstetter M. alpha-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner. Neurobiology of Disease 70:149-161 Gavriljuk K., Schartner J., Itzen A., Goody R.S., Gerwert K., Kötting C. Reaction Mechanism of Adenylyltransferase DrrA from Legionella pneumophila Elucidated by Time-Resolved Fourier Transform Infra-red Spectroscopy JACS 136:9338-9345 Gazdgag E.M., Schoebel S., Shkumatov A., Goody R.S., Itzen A. The structure of the N-terminal domain of the Legionella protein SidC. Journal of Structural Biology 186:188-194 Langemeyer L., Bastos R.N., Cai Y., Itzen A., Reinisch K.M., Barr F.A. Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation. eLife 2014;3:e01623 Li F, Yi L, Zhao L, Itzen A, Goody RS, Wu Y The role of the hypervariable C-terminal domain in Rab GTPases membrane targeting. PNAS 111:2572-2577 Spiegel J, Cromm PM, Itzen A, Goody RS, Grossmann TN, Waldmann H. Direct Targeting of Rab-GTPase-Effector Interactions. Angew Chem Int Ed Engl. 53:2498-2503