个人简介

Postdoctoral Research 04/04 Postdoctoral research with Prof. Benjamin F. Cravatt at the Scripps Research Institute in La Jolla, USA. “A Chemical-Proteomic Strategy for Targeting Cancer-Associated Enzymes“. Ph.D. 10/02-03/04 Research for doctoral thesis under the guidance of Prof. Mohamed A. Marahiel at Philipps-University in Marburg. “Nonribosomal Peptide Synthetases: Quaternary Structure and Chemoenzymatic Synthesis of Macrocyclic Peptides”. ("With distinction") 12/01-12/02 Research for doctoral thesis in the laboratory of Prof. Christopher T. Walsh at Harvard Medical School in Boston, USA.

研究领域

Organic Chemistry and Biochemistry

Prof. Sieber’s (b. 1976) research field is bioorganic chemistry. The aim of his work is to develop new drugs for multidrug-resistant bacteria. His research is based on methods which combine synthetic chemistry, functional proteomics, cell biology and mass spectrometry. This approach enables the discovery of new active substances, some of which are currently being optimized for medical application.

近期论文

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Gersch, M.*, Famulla, K.*, Dahmen M., Göbl, C., Malik, I., Richter, K., Korotkov, V. S., Sass, P., Rübsamen-Schaeff, H., Madl, T., Brötz-Oesterhelt, H., Sieber, S.A., "AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control", Nature Communications, accepted. Dahmen, M.*, Vielberg, M.-T.*, Groll, M., Sieber, S.A., "Structure and mechanism of the caseinolytic protease ClpP1/2 heterocomplex from Listeria monocytogenes", Angew. Chem. Int. Ed. doi Gersch, M., Hackl, M., Dubiella, C., Dobrinevski, A., Groll, M., Sieber S.A., "Intact protein mass spectrometry of 20S proteasomes reveals complex integrity, phosphorylation stoichiometry and inhibitor specificity", Chemistry & Biology, accepted. Artola, M., Ruiz-Avila, L.B., Vergoñós, A., Huecas, S., Araujo-Bazán, L., Martín-Fontecha, M., Vázquez-Villa, H., Turrado, C., Ramírez-Aportela, E., Hoegl, A., Nodwell, M., Barasoain, I., Chacón, P., Sieber, S.A., Andreu, J.M., López-Rodríguez, M.L., "Effective GTP-replacing FtsZ Inhibitors and Antibacterial Mechanism of Action", ACS Chemical Biology doi Rudolf*, G.C., Koch*, M.F., Mandl, F.A.M., Sieber, S.A., "Subclass-Specific Labeling of Protein-Reactive Natural Products with Customized Nucleophilic Probes", Chemistry - A European Journal doi Harvey, N.L., Krysiak, J., Chamni, S., Cho, S.W., Sieber, S.A., Romo, D., "Synthesis of (±)-Spongiolactone Enabling Discovery of a More Potent Derivative", Chemistry - A European Journal doi Kreuzer, J., Bach, N.C., Forler, D., Sieber, S.A., "Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition", Chem. Sci. doi Dubiella, C., Cui, H., Gersch, M., Brouwer, A.J., Sieber, S.A., Krüger, A., Liskamp, R.M.J., Groll, M., "Selective Inhibition of the Immunoproteasome by Ligand-Induced Crosslinking of the Active Site", Angew. Chem. doi Eirich, J., Braig, S., Schyschka, L., Servatius, P., Hoffmann, J., Hecht, S., Fulda, S., Zahler, S., Antes, I., Kazmaier, U., Sieber, S.A.*, Vollmar, A.M.*, "A small molecule protein disulfide inhibitor triggers chemosensitization of cancer cells", Angew. Chem. doi Wüstner, F., Mejías-Luque, R., Koch, M., Rath, E., Vieth, M., Sieber, S.A., Haller, D., Gerhard, M., "H. pylori γ-glutamyltranspeptidase impairs T lymphocyte function by compromising metabolic adaption through inhibition of cMyc and IRF4 expression", Cellular Microbiology doi Nodwell, M. B., Koch, M. F., Alte, F., Schneider, S., Sieber, S. A., "A Subfamily of Bacterial Ribokinases Utilizes a Hemithioacetal for Pyridoxal Phosphate Salvage", J. Am. Chem. Soc. doi Weinandy, F., Lorenz-Baath, K., Korotkov, V. S., Böttcher, T., Sethi, S., Chakraborty, T., Sieber, S. A., "A β-Lactone-Based Antivirulence Drug Ameliorates Staphylococcus aureus Skin Infections in Mice", ChemMedChem, 2014. doi Kunzmann, M. H., Bach, N. C., Bauer, B., Sieber, S. A., "α-Methylene-γ-butyrolactones attenuate Staphylococcus aureus virulence by inhibition of transcriptional regulation", Chem. Sci., 2014. doi Kolb, R., Bach, N.C., Sieber, S.A., "β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues", ChemComm, 2014. doi Gersch, M., Kolb, R., Alte, F., Groll, M., Sieber, S.A., "Disruption of oligomerization and dehydroalanine formation as mechanisms for ClpP protease inhibition", J. Am. Chem. Soc., 2014. doi List*, A., Zeiler*, E., Gallastegui, N., Rusch, M., Hedberg, C., Sieber, S.A., Groll, M., "Omuralide and Vibralactone: Differences in the Proteasome- β-Lactone-γ-Lactam Binding Scaffold Alter Target Preferences", Angew. Chem., 2014. doi Rudolf, G.C., Sieber, S.A., "Copper-Assisted Click Reactions for Activity-Based Proteomics: Fine-Tuned Ligands and Refined Conditions Extend the Scope of Application", ChemBioChem, 2013. doi Wolf, E., Zeißler, A., Vosyka O., Zeiler E., Sieber S.A., Verhelst S.H.L., "A New Class of Rhomboid Protease Inhibitors Discovered by Activity-Based Fluorescence Polarization", PLOS ONE, 2013, 8(8), e72307. doi Zeiler, E., List, A., Alte, F., Gersch, M., Wachtel, R., Poreba, M., Drag, M., Groll*, M., Sieber*, S.A., "Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad", Proc. Natl. Acad. Sci. USA, 2013, 110(28), 11302-11307. doi